apo+a1

Isoforms Recommended:	apoA1

By Targets:	Apolipoprotein (4) Biochemical Assay Reagents (1) Cytochrome P450 (1) DNA/RNA Synthesis (2) Epigenetic Reader Domain (1) Indoleamine 2,3-Dioxygenase (IDO) (9) Molecular Glues (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (10) Infection (2) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) Antisense Oligonucleotides (2) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111540

LY-3381916 2 Publications Verification IDO1-IN-5	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
LY-3381916 (IDO1-IN-5) is a potent, selective and brain penetrated inhibitor of *IDO1* activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 ^[1].

HY-151123A

Pelacarsen sodium AKCEA-APO(a)-LRx sodium; ISIS 681257 sodium; TQJ230 sodium	Apolipoprotein DNA/RNA Synthesis	Metabolic Disease
Pelacarsen sodium (ISIS 681257 sodium) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen sodium reduces apo (a) .

HY-151123

Pelacarsen AKCEA-APO(a)-LRx; ISIS 681257; TQJ230	Apolipoprotein DNA/RNA Synthesis	Metabolic Disease
Pelacarsen (ISIS 681257) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen reduces apo (a) .

HY-111540B

(S)-LY-3381916 1 Publications Verification (S)-IDO1-IN-5	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
(S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC₅₀ value less than 1.5 µΜ ^[1]. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .

HY-165061

5(Z),11(Z),14(Z)-Eicosatrienoic acid Sciadonic acid	Apolipoprotein	Inflammation/Immunology
5(Z),11(Z),14(Z)-Eicosatrienoic acid (Sciadonic acid), a polyunsaturated fatty acid sourced from maritime pine seed oil, gymnospermae leaves and seeds, and freshwater gastropods, has been shown to reduce high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1 when included in their diet. In vitro studies indicate that it diminishes cholesterol efflux, and when applied topically in its methyl ester form, it alleviates inflammatory processes, likely by displacing arachidonic acid from phospholipid pools and lowering concentrations of downstream inflammatory mediators such as prostaglandin E2 and leukotrienes.

HY-124187

Pinolenic acid ethyl ester Ethyl pinolenate	Biochemical Assay Reagents	Others
Pinolenic acid is a polyunsaturated fatty acid found in the seed oils of red pine (Pinus orientalis) and maritime pine (Pinus pinaster). Both oils were found to have lipid-lowering properties. A diet containing marine pine nut oil (MPSO) reduces HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to reduce cholesterol efflux in vitro. Korean pine nut oil supplements may help obesity by reducing appetite. People who take this oil experience an increase in the satiety hormones CCK and GLP-1 and a decrease in appetite. The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not metabolized to arachidonic acid and can reduce the level of arachidonic acid in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%. Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.

HY-177784

iDeg-3	Molecular Glues Indoleamine 2,3-Dioxygenase (IDO)	Infection Neurological Disease Cancer
iDeg-3 is a selective molecular glue degrader that targets *IDO1. iDeg-3 can competitively bind to the heme binding site of apo-IDO1, preventing heme binding and inhibiting the enzymatic reaction that converts tryptophan into kynurenine by IDO1 (IC₅₀* = 46 nM). iDeg-3 can be used for the researches of cancer, infection and neurological disease, such as melanoma ^[1].

HY-13031

GW 841819X	Epigenetic Reader Domain Apolipoprotein	Cancer
GW 841819X is a potent inducer of the *ApoA1* report gene, with an EC₁₇₀ of 0.22 µM, and its pIC₅₀ for Brd2/3/4 is 5.9/6.2/6.3 ^[1].

HY-178011

IDO1-IN-28	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-28 (Compound MQ-1) is a *Apo-IDO1* inhibitor with an IC₅₀ of 1.29  μM. IDO1-IN-28 selectively targets apo-IDO1 and disrupts heme binding. IDO1-IN-28 can be used for cancers research ^[1].

HY-178024

IDO1-IN-29	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-29 (Compound MQ-1n) is a *Apo-IDO1* inhibitor with an IC₅₀ of 0.29  μM. IDO1-IN-29 selectively targets apo-IDO1 and disrupts heme binding. IDO1-IN-29 can be used for cancers research ^[1].

HY-RS00829

APOA1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
APOA1 Human Pre-designed siRNA Set A contains three designed siRNAs for APOA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

APOA1 Human Pre-designed siRNA Set A APOA1 Human Pre-designed siRNA Set A

HY-177785

iDeg-6	Molecular Glues Indoleamine 2,3-Dioxygenase (IDO)	Infection Neurological Disease Cancer
iDeg-6 is a selective molecular glue degrader that targets *IDO1* with a DC₅₀ of 6.5 nM. iDeg-6 can competitively bind to the heme binding site of apo-IDO1, preventing heme binding and inhibiting the enzymatic reaction that converts tryptophan into kynurenine by IDO1 (IC₅₀ = 1.6 μM). iDeg-6 can be used for the researches of cancer, infection and neurological disease, such as melanoma ^[1].

HY-RS17077

Apoa1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Apoa1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apoa1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Apoa1 Mouse Pre-designed siRNA Set A Apoa1 Mouse Pre-designed siRNA Set A

HY-RS23521

Apoa1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Apoa1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Apoa1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Apoa1 Rat Pre-designed siRNA Set A Apoa1 Rat Pre-designed siRNA Set A

HY-172453

XW-032	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
XW-032 is an *apo-IDO1* inhibitor, with an IC₅₀ of 21 nM. XW-032 (TGI = 63%) exhibits potent in vivo anti-tumor efficacy in the CT26 syngeneic mouse model and is expected to be applied in the research of the field of cancer ^[1].

HY-111540A

(Rac)-LY-3381916 (Rac)-IDO1-IN-5	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
(Rac)-LY-3381916 ((Rac)-IDO1-IN-5; Example 1) is a racemate of LY-3381916 ^[1]. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .

HY-121698

GW694481	Cytochrome P450	Inflammation/Immunology
GW694481 is an *ApoA1* upregulator with IC₅₀ values of 2.1 μM for CYP2C9 inhibition and 17.0 μM for CYP3A4 inhibition. GW694481 upregulates *ApoA1* expression in human hepatic cells.GW694481 can be used for the research of atherosclerosis ^[1].

HY-181947

IDO1-IN-33	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-33 (Compound YC-16) is a *IDO1* inhibitor (with an IC₅₀ of 0.18 μM for IDO1 in HeLa cells). IDO1-IN-33 acts as an apo-IDO1 inhibitor by slowly and competitively displacing heme from mature holo-IDO1 and rapidly binding to the heme-binding site of immature apo-IDO1, without altering the expression level of IDO1. IDO1-IN-33 can be used for the research of hepatocellular carcinoma, non-small cell lung cancer, triple-negative breast cancer, and cervical cancer ^[1].

Cat. No.	Product Name	Type

HY-124187

Pinolenic acid ethyl ester Ethyl pinolenate	Biochemical Assay Reagents
Pinolenic acid is a polyunsaturated fatty acid found in the seed oils of red pine (Pinus orientalis) and maritime pine (Pinus pinaster). Both oils were found to have lipid-lowering properties. A diet containing marine pine nut oil (MPSO) reduces HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to reduce cholesterol efflux in vitro. Korean pine nut oil supplements may help obesity by reducing appetite. People who take this oil experience an increase in the satiety hormones CCK and GLP-1 and a decrease in appetite. The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not metabolized to arachidonic acid and can reduce the level of arachidonic acid in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%. Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.

Pinolenic acid ethyl ester

Ethyl pinolenate

Biochemical Assay Reagents

Pinolenic acid is a polyunsaturated fatty acid found in the seed oils of red pine (Pinus orientalis) and maritime pine (Pinus pinaster). Both oils were found to have lipid-lowering properties. A diet containing marine pine nut oil (MPSO) reduces HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to reduce cholesterol efflux in vitro. Korean pine nut oil supplements may help obesity by reducing appetite. People who take this oil experience an increase in the satiety hormones CCK and GLP-1 and a decrease in appetite. The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not metabolized to arachidonic acid and can reduce the level of arachidonic acid in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%. Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.

Cat. No.	Product Name	Target	Research Area

HY-P10453

Myr5A peptide	Peptides	Others
Myr5A peptide is an acylated peptide composed of apolipoprotein A1 (ApoA1) analog peptide 5A peptide coupled to the saturated fatty acid myristate. Myr5A peptide self-assembled into lipid nanostructures can be used to encapsulate anthracycline Doxorubicin (HY-15142A) and Valrubicin (HY-13772) for compound release studies in vitro ^[1].

Species:	Human (3) Mouse (2)
Tag:	His (1) Tag Free (1) Fc (3)
Source:	HEK293 (4) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P7526

	*Apolipoprotein A-I/APOA1 Protein, Human* 1 Publications Verification rHuApolipoprotein A-I; ApoA1; Apolipoprotein A-I	Human	E. coli
	Apolipoprotein A-I/APOA1 Protein is a secreted protein located on the outside of cell membranes and is the main structural apolipoprotein of high-density lipoprotein (HDL), playing a key role in the reverse cholesterol transport pathway. Apolipoprotein A-I/APOA1 protein interacts with the cell surface receptor SR-BI, thereby promoting dengue virus (DV) infection. Apolipoprotein A-I/APOA1 Protein can also activate sperm motility as part of the SPAP complex. Apolipoprotein A-I/APOA1 Protein has anti-inflammatory, anti-atherosclerotic, anti-apoptotic, anti-tumor, and anti-thrombotic functions. Apolipoprotein A-I/APOA1 Protein Protein, Human is made up of 267 amino acids and is expressed in Escherichia coli (E. coli).

HY-P78238

	*Apolipoprotein A-I/APOA1 Protein, Mouse (Truncated, HEK293, Fc)* Apo-AI; ProapoA-I; Apoa1; Apolipoprotein A-I; APOA1; MGC117399; Alp-1; Brp-14; Ltw-1; Lvtw-1; Sep-1; Sep-2	Mouse	HEK293
	The apolipoprotein AI (APOA1) protein is key to reverse cholesterol transport, promoting tissue efflux, and serves as an important cofactor for lecithin cholesterol acyltransferase (LCAT), promoting cholesterol excretion. As a homodimer, APOA1 is a component of the sperm activating protein complex (SPAP), interacts with APOA1BP, CLU, NDRG1, SCGB3A2, NAXE and YJEFN3, exhibiting multiple molecular associations. Apolipoprotein A-I/APOA1 Protein, Mouse (Truncated, HEK293, Fc) is the recombinant mouse-derived Apolipoprotein A-I/APOA1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P7525

	*Apolipoprotein A-I/APOA1 Protein, Human (HEK293, His)* 3 Publications Verification rHuApolipoprotein A-I, His; ApoA1; Apolipoprotein A-I	Human	HEK293
	Apolipoprotein A-I Protein, Human (HEK293, His) expresses in HEK293 with a His tag at the N-terminus. Apolipoprotein A-I (ApoA-I), the major protein component in high-density lipoprotein (HDL), plays key roles in the Reverse Cholesterol Transport pathway. Apolipoprotein A-I is associated with dengue virus (DV) particles and enhances virus infection through SR-BI.

HY-P72833

	*Apolipoprotein A-I/APOA1 Protein, Mouse (HEK293, Fc)* 2 Publications Verification Apolipoprotein A-I; Apo-AI; ProapoA-I; APOA1	Mouse	HEK293
	The apolipoprotein AI (APOA1) protein is key to reverse cholesterol transport, promoting tissue efflux, and serves as an important cofactor for lecithin cholesterol acyltransferase (LCAT), promoting cholesterol excretion. As a homodimer, APOA1 is a component of the sperm activating protein complex (SPAP), interacts with APOA1BP, CLU, NDRG1, SCGB3A2, NAXE and YJEFN3, exhibiting multiple molecular associations. Apolipoprotein A-I/APOA1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Apolipoprotein A-I/APOA1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72832

	*Apolipoprotein A-I/APOA1 Protein, Human (HEK293, Fc)* 1 Publications Verification Apolipoprotein A-I; Apo-AI; ProapoA-I; APOA1	Human	HEK293
	Apolipoprotein AI plays a key role in reverse cholesterol transport, promoting cholesterol efflux from tissues and acting as a cofactor for lecithin cholesterol acyltransferase (LCAT). It forms homodimers and participates in the SPAP complex, which is essential for sperm motility, interacting with both NAXE and CLU. Apolipoprotein A-I/APOA1 Protein, Human (HEK293, Fc) is the recombinant human-derived Apolipoprotein A-I/APOA1 protein, expressed by HEK293 , with C-hFc labeled tag.

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HY-P85038

	ApoA-I Antibody (YA4730) APOA1; Apolipoprotein A-I; Apo-AI; ApoA-I; Apolipoprotein A1	WB, ELISA	Human
	ApoA-I Antibody (YA4730) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ApoA-I.

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Cat. No.	Product Name		Classification

HY-151123A

Pelacarsen sodium AKCEA-APO(a)-LRx sodium; ISIS 681257 sodium; TQJ230 sodium		Antisense Oligonucleotides
Pelacarsen sodium (ISIS 681257 sodium) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen sodium reduces apo (a) .

HY-151123

Pelacarsen AKCEA-APO(a)-LRx; ISIS 681257; TQJ230		Antisense Oligonucleotides
Pelacarsen (ISIS 681257) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen reduces apo (a) .

HY-RS00829

APOA1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
APOA1 Human Pre-designed siRNA Set A contains three designed siRNAs for APOA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17077

Apoa1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Apoa1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apoa1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23521

Apoa1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Apoa1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Apoa1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Biochemical Assay Reagents

Peptides

Recombinant Proteins

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