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Cat. No.: HY-121698

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GW694481

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

GW694481 is an ApoA1 upregulator with IC₅₀ values of 2.1 μM for CYP2C9 inhibition and 17.0 μM for CYP3A4 inhibition. GW694481 upregulates ApoA1 expression in human hepatic cells.GW694481 can be used for the research of atherosclerosis.

For research use only. We do not sell to patients.

CAS No.: 1373353-95-7
Formula: C₂₁H₁₈N₄O₂
Molecular Weight:358.39

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Please store the product under the recommended conditions in the Certificate of Analysis.

GW694481 Chemical Structure

CAS No.: 1373353-95-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Description
- In Vitro
Chemical Information
Publications (1)
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Biological Activity

Description

All Cytochrome P450 Isoforms :

In Vitro

GW694481 upregulates ApoA1 expression in stably transfected HepG2 cells with an EC₁₇₀ of 0.52 μM, and inhibits CYP 2C9 and CYP 3A4 with IC₅₀ values of 2.1 μM and 17.0 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1373353-95-7
Molecular Weight 358.39
Formula C₂₁H₁₈N₄O₂
SMILES

O=C(C1=CN=C2C=C(C3=C(C)ON=C3C)C=CC2=C1NC4=CC=CC=C4)N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Adv Sci (Weinh)

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4-Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR-Linked Pro-Clearance State. [Abstract]

2026 Jun 22:e24167. PMID: 42330346

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mirguet O, et al. From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151. Bioorg Med Chem Lett. 2012;22(8):2963-2967. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References

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GW694481

Publications Citing Use of MedChemExpress (MCE) GW694481

All Cytochrome P450 Isoforms