ApoA-I Antibody (YA4730)
(別名: APOA1; Apolipoprotein A-I; Apo-AI; ApoA-I; Apolipoprotein A1)ApoA-I Antibody (YA4730) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ApoA-I.
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Host:
Mouse
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Application:
WB, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:10000 |
Product Details
ApoA-I Antibody (YA4730) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ApoA-I.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 31 kDa;
Purified recombinant fragment of human ApoA-I expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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輸送条件
Shipping with blue ice.
Background
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Function
ApoA-I participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility
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Subcellular Localization
Secreted
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Expression
Tissue_specificity:High-density lipoprotein (HDL) , the main protein in plasma, is also found in chylomicrons. It is synthesized by the liver and small intestine. Oxidized forms at Met-110 and Met-136 are elevated in high-risk individuals for coronary artery disease, such as eNOSa/b genotype carriers and smokers. The levels of this form are also elevated in aortic lesions compared to native ApoA-I, and increase with disease severity. -
Subunit
Homodimer (By similarity). Interacts with NAXE and CLU (PubMed:11991719, PubMed:1742316). Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin (PubMed:1909888). Interacts with NDRG1 (PubMed:15922294). Interacts with SCGB3A2 (PubMed:12847263). Interacts with NAXE and YJEFN3 (PubMed:23719382)
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SwissProt ID
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別名
APOA1; Apolipoprotein A-I; Apo-AI; ApoA-I; Apolipoprotein A1
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