APOA1 - apolipoprotein A1 Gene

Also Known as HPALP2; apo(a)

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 335

About APOA1

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:116,835,751-116,837,950 (from NCBI)

This gene has 5 transcripts (splice variants), 193 orthologues, 3 paralogues and is associated with 6 phenotypes. Biased expression in liver (RPKM 4032.4), small intestine (RPKM 1199.8) and 1 other tissue.

Summary

This gene encodes Apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes Cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other Apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]

APOA1 Products (4)

mRNA	Protein	Name
NM_000039.3	NP_000030.1	apolipoprotein A-I isoform 1 preproprotein
NM_001318017.2	NP_001304946.1	apolipoprotein A-I isoform 1 preproprotein
NM_001318018.2	NP_001304947.1	apolipoprotein A-I isoform 1 preproprotein
NM_001318021.1	NP_001304950.1	apolipoprotein A-I isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables amyloid-beta binding	IDA IDA: Inferred from direct assay	11297421	GOA
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	9211985	GOA
enables apolipoprotein A-I receptor binding	IPI IPI: Inferred from physical interaction	16443932	GOA
enables apolipoprotein receptor binding	IPI IPI: Inferred from physical interaction	11162594	GOA
enables chemorepellent activity	IDA IDA: Inferred from direct assay	23726972	GOA
enables cholesterol binding	IDA IDA: Inferred from direct assay	15464323	GOA
contributes to cholesterol transfer activity	IDA IDA: Inferred from direct assay	9651324	GOA
enables cholesterol transfer activity	IMP IMP: Inferred from mutant phenotype	15464323	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	1587806	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	11027668	GOA
enables high-density lipoprotein particle receptor binding	IPI IPI: Inferred from physical interaction	10764676	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	8049247	GOA
enables phosphatidylcholine-sterol O-acyltransferase activator activity	IDA IDA: Inferred from direct assay	4335615	GOA
enables phospholipid binding	IDA IDA: Inferred from direct assay	12810715	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1587806	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	27477018	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	27477018	GOA

Biological Process GO Annotation	Evidence	References	Source
NOT involved in ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	23726972	GOA
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	16443932	GOA
involved in cellular response to lipoprotein particle stimulus	IDA IDA: Inferred from direct assay	27477018	GOA
involved in cholesterol efflux	IDA IDA: Inferred from direct assay	11162594	GOA
involved in cholesterol efflux	IMP IMP: Inferred from mutant phenotype	12202492	GOA
involved in cholesterol homeostasis	IDA IDA: Inferred from direct assay	21571275	GOA
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	15464323	GOA
involved in cholesterol import	IMP IMP: Inferred from mutant phenotype	14718538	GOA
involved in cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	15464323	GOA
acts upstream of or within cholesterol transport	IDA IDA: Inferred from direct assay	10559507	GOA
involved in high-density lipoprotein particle assembly	IDA IDA: Inferred from direct assay	190223	GOA
involved in high-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	4335615	GOA
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	23726972	GOA
involved in negative chemotaxis	IDA IDA: Inferred from direct assay	23726972	GOA
involved in negative regulation of cell adhesion molecule production	IDA IDA: Inferred from direct assay	21571275	GOA
involved in negative regulation of cytokine production involved in immune response	IDA IDA: Inferred from direct assay	12458630	GOA
involved in negative regulation of heterotypic cell-cell adhesion	IDA IDA: Inferred from direct assay	21571275	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	21571275	GOA
involved in negative regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	12458630	GOA
involved in negative regulation of response to cytokine stimulus	IDA IDA: Inferred from direct assay	21571275	GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	21571275	GOA
involved in negative regulation of very-low-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	14967812	GOA
involved in peptidyl-methionine modification	IDA IDA: Inferred from direct assay	12576517	GOA
involved in phosphatidylcholine biosynthetic process	IDA IDA: Inferred from direct assay	4335615	GOA
involved in phospholipid efflux	IDA IDA: Inferred from direct assay	11162594	GOA
involved in phospholipid homeostasis	IDA IDA: Inferred from direct assay	21571275	GOA
involved in positive regulation of CoA-transferase activity	IDA IDA: Inferred from direct assay	4335615	GOA
involved in positive regulation of Rho protein signal transduction	IDA IDA: Inferred from direct assay	23726972	GOA
involved in positive regulation of cholesterol efflux	IDA IDA: Inferred from direct assay	27472885	GOA
involved in positive regulation of cholesterol metabolic process	IDA IDA: Inferred from direct assay	4335615	GOA
involved in positive regulation of hydrolase activity	IDA IDA: Inferred from direct assay	7638166	GOA
involved in positive regulation of phagocytosis	IDA IDA: Inferred from direct assay	20495215	GOA
involved in positive regulation of phospholipid efflux	IDA IDA: Inferred from direct assay	27472885	GOA
involved in positive regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	23726972	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	23726972	GOA
involved in protein oxidation	IDA IDA: Inferred from direct assay	12576517	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	17655203	GOA
involved in regulation of Cdc42 protein signal transduction	IDA IDA: Inferred from direct assay	16443932	GOA
involved in reverse cholesterol transport	IMP IMP: Inferred from mutant phenotype	15464323	GOA
NOT involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	23726972	GOA
involved in triglyceride homeostasis	IDA IDA: Inferred from direct assay	21571275	GOA
involved in vitamin transport	IMP IMP: Inferred from mutant phenotype	15140193	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	14703508	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	14747463	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	19433579	GOA
part of high-density lipoprotein particle	IDA IDA: Inferred from direct assay	210174	GOA
part of spherical high-density lipoprotein particle	IDA IDA: Inferred from direct assay	16682745	GOA
part of very-low-density lipoprotein particle	IDA IDA: Inferred from direct assay	17154273	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOA1 Protein Structure

Apolipoprotein

0
100
200
267 a.a.

Protein Preferred Names	Protein Names
apolipoprotein A-I	apo-AI

APOA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	APOA1	P02647	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	25910212
Intra	APOA1	P02647	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	32296183
Intra	APOA1	P02647	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	APOA1	P02647	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Bait-Prey Pool	25910212
Intra	APOA1	P02647	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	32296183
Intra	APOA1	P02647	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	25910212
Intra	APOA1	P02647	HP	Homo sapiens	P00738	Competition Binding	19758344
Intra	APOA1	P02647	HP	Homo sapiens	P00738	ELISA	19758344
Intra	APOA1	P02647	MAPK6	Homo sapiens	Q16659	Y2H	21900206
Intra	APOA1	P02647	CMTM5	Homo sapiens	Q96DZ9	Y2H Array	25416956
Intra	APOA1	P02647	APOA1	Homo sapiens	P02647	LM	20133843
Intra	APOA1	P02647	APOA1	Homo sapiens	P02647	Crosslink	20884842
Intra	APOA1	P02647	APOA1	Homo sapiens	P02647	X-Ray Fiber Diffrac	22609356
Intra	APOA1	P02647	APOA1	Homo sapiens	P02647	DLS	24316228
Intra	APOA1	P02647	APOA1	Homo sapiens	P02647	Solution Sedimentation	20133843
Intra	APOA1	P02647	APOA1	Homo sapiens	P02647	Crosslink	18719128
Intra	APOA1	P02647	APOA1	Homo sapiens	P02647	Solution Sedimentation	20884842
Intra	APOA1	P02647	APOA1	Homo sapiens	P02647	X-Ray Fiber Diffrac	20133843
Intra	APOA1	P02647	APOA1	Homo sapiens	P02647	Comig Non-Denat Gel	20884842
Intra	APOA1	P02647	APOA1	Homo sapiens	P02647	TEM	22609356
Intra	APOA1	P02647	APOA1	Homo sapiens	P02647	TEM	20133843
Intra	APOA1	P02647	APOA1	Homo sapiens	P02647	Fluorescence	22609356
Intra	APOA1	P02647	APOA1	Homo sapiens	P02647	EM	22184756
Intra	APOA1	P02647	APOA1	Homo sapiens	P02647	Fluorescence	24316228
Intra	APOA1	P02647	APOA1	Homo sapiens	P02647	Photoaffinity Labelling	17676061
Intra	APOA1	P02647	APOA1	Homo sapiens	P02647	AFM	24316228
Intra	APOA1	P02647	APOA1	Homo sapiens	P02647	Fluorescence Spectr	20133843
Intra	APOA1	P02647	APP	Homo sapiens	P05067	Anti Tag CoIP	11297421
Intra	APOA1	P02647	APP	Homo sapiens	P05067	Y2H	11297421
Intra	APOA1	P02647	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	APOA1	P02647	APP	Homo sapiens	P05067	Y2H Pooling	32814053
Intra	APOA1	P02647	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	APOA1	P02647	ABCA1	Homo sapiens	O95477	Crosslink	12084722
Intra	APOA1	P02647	ABCA1	Homo sapiens	O95477	Confocal	30458687
Intra	APOA1	P02647	LCAT	Homo sapiens	P04180	Affinity Chrom	1587806
Intra	APOA1	P02647	LCAT	Homo sapiens	P04180	SLCA	17676061

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant APOA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7525	Apolipoprotein A-I/APOA1 Protein, Human (HEK293, His)	P02647 (R19-Q267)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7526	Apolipoprotein A-I/APOA1 Protein, Human	P02647 (R19-Q267)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72832	Apolipoprotein A-I/APOA1 Protein, Human (HEK293, Fc)	P02647/CAA26097.1 (D25-Q267)	≥ 95%, as determined by reducing SDS-PAGE.

APOA1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81137	ApoA-I Antibody (YA3481)	WB, IHC-P, ICC/IF, IP	Human, Mouse
HY-P85038	ApoA-I Antibody (YA4730)	WB, ELISA	Human

Related Diseases

Diseases	Alias
Hypoalphalipoproteinemia, Primary, 2	Apolipoprotein A-I Deficiency Hypoalphalipoproteinemia, Primary, 2, Autosomal Recessive Primary Hypoalphalipoproteinemia 2 High Density Lipoprotein Deficiency Apoa-I Deficiency Familial Apoa-I Deficiency Familial Hypoalphalipoproteinemia FHA2 Apolipoprotein A-I
Amyloidosis, Familial Visceral	Ostertag Type Amyloidosis German Type Amyloidosis Familial Renal Amyloidosis Amyloidosis Viii Amyloidosis, 3 Or More Types Familial Visceral Amyloidosis Familial Amyloid Nephropathy Hereditary Amyloid Nephropathy Amyloidosis, Familial Renal Amyloidosis, Systemic Nonneuropathic Amyloidosis Familial Visceral Amyloidosis 8 Amyloidosis, Ostertag Type Hereditary Amyloidosis With Primary Renal Involvement Hereditary Renal Amyloidosis Renal Amyloidosis Amyloidosis, Renal Systemic Nonneuropathic Amyloidosis Amyloidosis Familial Renal Amyloidosis Systemic Nonneuropathic Hereditary Amyloidosis With Primary Renal Involement AMYL8 Systemic Non-Neuropathic Amyloidosis Amyloid Nephropathy
Hypoalphalipoproteinemia, Primary, 2, Intermediate	Hypoalphalipoproteinemia, Primary, 2, Autosomal Dominant FHA2I
Aapoai Amyloidosis	Apolipoprotein A-I Amyloidosis Familial Amyloid Nephropathy Due To Apolipoprotein A-I Variant Familial Renal Amyloidosis Due To Apolipoprotein A-I Variant Hereditary Amyloid Nephropathy Due To Apolipoprotein A-I Variant Hereditary Renal Amyloidosis Due To Apolipoprotein A-I Variant
Tangier Disease	Analphalipoproteinemia High Density Lipoprotein Deficiency, Tangier Type TGD High Density Lipoprotein Deficiency, Type 1 Hdldt1 Familial High Density Lipoprotein Deficiency A-Alphalipoprotein Neuropathy Alpha High Density Lipoprotein Deficiency Disease Cholesterol Thesaurismosis Familial High Density Lipoprotein Deficiency Disease Hdl Lipoprotein Deficiency Disease Tangier Disease Neuropathy Familial Alpha-Lipoprotein Deficiency Familial High-Density Lipoprotein Deficiency 1 Primary Hypoalphalipoproteinemia 1 Analphalipo-Proteinemia Familial Hypoalphalipo-Proteinemia Familial Hypoalphalipoproteinemia Lipoprotein Deficiency Disease, Hdl, Familial Tangier Hereditary Neuropathy Atp-Binding Cassette Transporter A1 Deficiency Hdld1 High Density Lipoprotein Deficiency 1 Tangier Disease, Variant Hypoalphalipoproteinemia, Familial Familial Hdl Deficiency
Hypoalphalipoproteinemia, Primary, 1	Familial Hdl Deficiency Fha High Density Lipoprotein Deficiency Familial Hypoalphalipoproteinemia Hypoalphalipoproteinemia, Familial Hdld Fhd Hdl Deficiency, Type 2 Primary Hypoalphalipoproteinemia 1 Hdl Cholesterol, Low Serum Hdlc Hdl Deficiency, Familial, 1 Hypoalphalipoproteinemia, Primary Low Serum Hdl Cholesterol Primary Hypoalphalipoproteinemia FHA1 Hdld2 High Density Lipoprotein Deficiency 2 Hypoalphalipoproteinemias Apolipoprotein A-I Deficiency
Spastic Paraplegia 50, Autosomal Recessive	Hereditary Spastic Paraplegia 50 SPG50 Ap-4 Deficiency Syndrome Ap-4-Associated Hereditary Spastic Paraplegia Adaptor Protein Complex 4 Deficiency Cerebral Palsy, Spastic Quadriplegic, 3, Formerly Cpsq3, Formerly Autosomal Recessive Spastic Paraplegia 50 Cpsq3 Spastic Quadriplegic Cerebral Palsy 3 Ap-4 Deficiency Ap-4-Associated Hsp Paraplegia, Spastic, Autosomal Recessive, Type 50 Spastic Paraplegia-50, Autosomal Recessive
Hypoalphalipoproteinemia
Familial Hyperlipidemia	Familial Hyperlipoproteinemia Hyperlipidaemia Hyperlipoproteinemias Hyperlipidemia Hyperlipemia Hyperlipidemias
Coronary Stenosis	Coronary Artery Stenosis
Amyloidosis	Amyloid Disease Amyloid Amyloid Degeneration Amyloidosis Nos Amyloid Deposition Amyloid Infiltration Idiopathic Amyloidosis Hyaloid Degeneration Lardaceous Degeneration
Lecithin:Cholesterol Acyltransferase Deficiency	Norum Disease Lcat Deficiency Familial Lcat Deficiency Fld Lecithin Acyltransferase Deficiency Complete Lcat Deficiency Lecithin Cholesterol Acyltransferase Deficiency Lecithin-Cholesterol Acyltransferase Deficiency Familial Lecithin-Cholesterol Acyltransferase Deficiency Norum'S Disease LCATD Deficiency, Lecithin:Cholesterol Acyltransferase
Arteriosclerosis	Arteriosclerotic Vascular Disease
Hyperalphalipoproteinemia 1	Hyperalphalipoproteinemia HALP1 Cetp Deficiency Cholesterol-Ester Transfer Protein Deficiency Familial Hyperalphalipoproteinemia Cholesteryl Ester Transfer Protein Deficiency Cept Deficiency Cholesterol Ester Transfer Protein Deficiency
Hereditary Amyloidosis	Amyloidosis Hereditary Familial Amyloidosis Amyloidosis Familial Amyloidosis, Hereditary Amyloidosis, Familial Genetic Amyloidosis Heredofamilial Amyloidosis
Arcus Corneae	Arcus Senilis Corneal Arcus Arcus Of Cornea
Cerebral Atherosclerosis	Intracranial Arteriosclerosis
Abetalipoproteinemia	Acanthocytosis ABL Bassen-Kornzweig Syndrome Mtp Deficiency Familial Hypobetalipoproteinemia Abetalipoproteinaemia Microsomal Triglyceride Transfer Protein Deficiency Microsomal Triglyceride Transfer Protein Deficiency Disease Abetalipoproteinemia Neuropathy Apolipoprotein B Deficiency Bassen-Kornzweig Disease Betalipoprotein Deficiency Disease Congenital Betalipoprotein Deficiency Syndrome Homozygous Familial Hypobetalipoproteinemia Fhbl Bassen Kornzweig Syndrome Hypobetalipoproteinemia, Familial Hypobetalipoproteinemia Hypobetalipoproteinemias Hypobetalipoproteinemia, Familial, Apolipoprotein B
Fish-Eye Disease	FED Dyslipoproteinemic Corneal Dystrophy Alpha-Lcat Deficiency Lcata Deficiency Partial Lcat Deficiency Alpha-Lecithin:Cholesterol Acyltransferase Deficiency Alpha-Lecithin Cholesterol Acyltransferase Deficiency Disease, Fish-Eye Lecithin Acyltransferase Deficiency
Amyloidosis, Hereditary, Transthyretin-Related	Transthyretin Amyloidosis Familial Amyloid Polyneuropathy Ttr Amyloid Neuropathy Transthyretin Amyloid Neuropathy Transthyretin Amyloid Polyneuropathy Fap Familial Transthyretin Amyloidosis Amyloidosis Transthyretin Related Type I Familial Amyloid Polyneuropathy Familial Amyloid Polyneuropathy Type I Attrv122i Amyloidosis Hereditary Amyloidosis, Transthyretin-Related Amyloid Polyneuropathy, Familial Attr Amyloidosis Attrm Amyloidosis Corino De Andrade'S Disease Paramyloidosis Transthyretin-Related Hereditary Amyloidosis Ttr Amyloidosis Hereditary Attr Amyloidosis Portuguese Polyneuritic Amyloidosis Portuguese Type Familial Amyloid Neuropathy Swiss Type Amyloid Polyneuropathy Type Ii Familial Amyloid Polyneuropathy Attrv30m Amyloidosis Attrv30m-Related Amyloidosis Familial Amyloid Polyneuropathy, Portuguese-Swedish-Japanese Type Attr Cardiomyopathy Attrv122i-Related Amyloidosis Ttr-Related Amyloid Cardiomyopathy Ttr-Related Cardiac Amyloidosis Transthyretin Amyloid Cardiopathy Transthyretin-Related Familial Amyloid Cardiomyopathy Amyloidosis, Transthyretin-Related AMYL-TTR Amyloidosis I Amyloidosis Ohio Type Amyloidosis Type 7 Amyloidosis Vii Amyloid Polyneuropathy Attr Familial Amyloid Polyneuropathy Type Ii Hereditary Amyloidosis Transthyretin-Related Leptomeningeal Amyloidosis Meningocerebrovascular Amyloidosis Oculoleptomeningeal Amyloidosis Familial Amyloid Polyneuropathies Amyloidosis, Leptomeningeal Senile Cardiac Amyloidosis Amyloid Neuropathies, Familial Danish Type Familial Amyloid Cardiomyopathy Familial Amyloid Neuropathy, Portuguese Type Amyloid Polyneuropathy, Swiss Type Hereditary Oculoleptomeningeal Amyloid Angiopathy Amyloid Neuropathies
Hypobetalipoproteinemia, Familial, 1	Hypobetalipoproteinemia Familial Hypobetalipoproteinemia 1 Familial Hypobetalipoproteinemia FHBL1 Hypobetalipoproteinemia, Familial Fhbl Acanthocytosis With Hypobetalipoproteinemia Hypobetalipoproteinemias Hypobetalipoproteinemia, Normotriglyceridemic Hypo-Beta-Lipoproteinemia Hypobetalipoprotéinemia, Familial Normotriglyceridemic Hypobetalipoproteinemia Hypobetalipoproteinemia, Familial, Type 1
Polyneuropathy	Polyneuropathies
Familial Hypercholesterolemia	Hyperlipoproteinemia Type Iia Familial Hyperbetalipoproteinaemia Familial Hypercholesteremia Fredrickson Type Iia Hyperlipoproteinemia Fredrickson Type Iia Lipidaemia Hyperbetalipoproteinemia Type Ii Hyperlipidemia Familial Hypercholesterolæmia Familial Hypercholesterolaemia Fh Hypercholesterolemia Familial Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial
Hyperlipidemia, Familial Combined, 3	Familial Combined Hyperlipidemia Combined Hyperlipidemia, Familial Mixed Hyperlipidaemia FCHL3 Hyperlipidemia, Familial Combined Familial Multiple Lipoprotein-Type Hyperlipidemia Hyperbetalipoproteinemia With Prebetalipoproteinemia Type Iib Hyperlipoproteinemia Hyperlipidemia Familial Combined Hyperlipoproteinemia Type Iib Mixed Hyperlipemia Hyperlipidaemia, Group C Familial Hypercholesterolaemia With Hyperlipaemia Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia Hyperbetalipoproteinaemia With Prebetalipoproteinaemia Hypercholesterolaemia With Endogenous Hyperglyceridaemia Prebetalipoproteinemia Hyperbetalipoproteinaemia Remnant Hyperlipoproteinemia
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Hypertriglyceridemia 1	Hypertriglyceridemia Hypertriglyceridemia, Familial Hypertriglyceridemia, Susceptibility To HYTG1 FHTR Hypertriglyceridemias Familial
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Angina Pectoris	Prinzmetal'S Variant Angina Angina Prinzmetal Angina Variant Angina Angina Inversa Prinzmetal'S Angina Coronary Artery Vasospasm Angina Pectoris, Variant Variant Angina Pectoris Vasospastic Angina Angor Pectoris Anginal Syndrome Ischaemic Chest Pain Angina Pectoris Syndrome Angina Syndrome Cardiac Angina Syndrome Ap - [Angina Pectoris] Angina Nos Ap - [Angina Pectoris] Syndrome Ischaemic Heart Disease With Angina Heart Angina Chest Angina Angina Attack Anginal Cardiopathy Coronary Pain Nos
Aortic Atherosclerosis	Atherosclerosis Of Aorta Aorta Atheroma Aorta Calcification Aorta Arteriosclerosis Aortic Degeneration Aortic Calcification Aortic Atheroma Aortic Arteriosclerotic Disease Aortic Arteriosclerosis Aorta Sclerosis Aorta Degeneration Atheromatous Aortic Calcified Aortic Stenosis Atheromatous Aorta Arteriosclerotic Aortitis Arteriosclerotic Aortic Stenosis Arteriosclerotic Aorta Disease Aortic Sclerosis
Hypolipoproteinemia	Hypolipoproteinaemia Lipoprotein Deficiencies Lipoprotein Disorder Hypolipoproteinemias Lipoprotein Lipoprotein Deficiency Hypolipidaemia Lipoprotein Deficiency Disorder High-Density Lipoid Deficiency High-Density Lipoprotein Deficiency Dyslipidaemia, Depressed Hdl Cholesterol
Hyperlipoproteinemia, Type Iii	Hyperlipoproteinemia Type Iii Broad-Betalipoproteinemia Floating-Betalipoproteinemia Familial Type 3 Hyperlipoproteinemia Broad Beta Disease Familial Hyperbeta- And Prebetalipoproteinemia Familial Hypercholesterolemia With Hyperlipemia Hyperlipemia With Familial Hypercholesterolemic Xanthomatosis Coronary Artery Disease, Severe, Susceptibility To Coronary Artery Disease, Severe Hyperlipidemia Type 3 Familial Dysbetalipoproteinemia Hyperlipoproteinemia Type 3 Coronary Artery Disease Apolipoprotein E, Deficiency Or Defect Of Dysbetalipoproteinemia Due To Defect In Apolipoprotein E-D Carbohydrate Induced Hyperlipemia Familial Hypercholesterolaemia With Hyperlipaemia Remnant Hyperlipidemia Remnant Removal Disease Dysbetalipoproteinemia Broad-Beta Disease Familial Dyslipidemia Type 3 Hlp Type 3 Remnant Hyperlipoproteinemia Familial Hyperlipoproteinemia Type Iii CAD Hyperlipoproteinemia 3 HLPP3 Deficiency Or Defect Of Apolipoprotein E Dysbetalipoproteinemia Due To Defect In Apolipoprotein E Coronary Arteriosclerosis Coronary Heart Disease
Fetal Macrosomia
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Coronary Heart Disease 1	Coronary Heart Disease Coronary Heart Disease, Susceptibility To, 1 Chds1 Coronary Heart Disease, Susceptibility To CHD Heart, Coronary, Disease, Susceptibility To, Type 1 Coronary Arteriosclerosis Coronary Artery Disease
Acute Myocardial Infarction	Cardiac Attack Heart Attack
Hepatoblastoma
Wild-Type Amyloidosis	Senile Systemic Amyloidosis Attrwt Amyloidosis Age Related Amyloidosis Old Age Amyloidosis Wild-Type Attr Amyloidosis Wild-Type Transthyretin Cardiac Amyloidosis Wild Type Attr Amyloidosis Attrwt-Related Amyloidosis Wild Type Attr-Related Amyloidosis
Amyloid Neuropathy	Amyloid Neuropathies Neuropathy Amyloid
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Serum Amyloid A Amyloidosis	Aa Amyloidosis Secondary Amyloidosis Reactive Systemic Amyloidosis Apo Serum Amyloid A Amyloidosis Inflammation Aa Amyloidosis Amyloidosis Aa Amyloid A Amyloidosis Inflammatory Amyloidosis Reactive Amyloidosis Amyloidosis Secondary Secondary Systemic Amyloidosis Amyloid Aa
Hyperlipoproteinemia, Type V	Hyperlipoproteinemia Type V Hyperchylomicronemia, Late-Onset Familial Type 5 Hyperlipoproteinemia Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial Hyperlipidemia, Type V Hyperlipemia, Mixed Hyperlipemia, Combined Fat And Carbohydrate-Induced Familial Hyperlipoproteinemia Type V Fredrickson Type V Lipaemia Hyperlipoproteinemia Type 5 Hyperchylomicronemia Late Onset Hyperlipemia Combined Fat And Carbohydrate-Induced Hyperlipemia Mixed Hyperlipidemia Type V Mixed Hyperlipemia Type V Hyperlipoproteinemia Hyperlipoproteinemia 5 HLPP5 Hyperlipidemia, Familial Combined Mixed Hyperlipidemia
Sleeping Sickness	African Trypanosomiasis African Sleeping Sickness Trypanosomiasis, Human East-African Trypanosomiasis, East African Trypanosomiasis African Trypanosomiasis, African Human African Trypanosomiasis
Pyloric Stenosis
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Diabetes Mellitus	Diabetes
Hyperlipoproteinemia, Type Iv	Hyperlipoproteinemia Type Iv Carbohydrate-Inducible Hyperlipemia Endogenous Hyperlipidaemia Familial Hypertriglyceridemia Fredrickson Type Iv Hyperlipoproteinemia Fredrickson Type Iv Lipidaemia Fredrickson Type Iv Lipidemia Vldl Hyperlipoproteinemia Hyperlipoproteinemia Type 4 Carbohydrate Inducible Hyperlipemia Familial Type Iv Hyperlipoproteinemia Familial Hyperlipoproteinemia Type Iv
Varicose Veins	Varices Varix Venous Ectasia Venous Varices Varicosity
Glucose Intolerance	Glucose: Intolerance Glucose: Malabsorption Malabsorption Of Glucose Impaired Glucose Tolerance
Hypercholesterolemia, Familial, 1	Hypercholesterolemia FHCL1 Fhc Fh Hyperlipoproteinemia, Type Ii Hyperlipoproteinemia, Type Iia Hyper-Low-Density-Lipoproteinemia Hypercholesterolemic Xanthomatosis, Familial Ldl Receptor Disorder Hypercholesterolemia, Susceptibility To Hypercholesterolemia, Familial, Modifier Of Hypercholesterolemia, Familial, Due To Ldlr Defect, Modifier Of Ldl Cholesterol Level Qtl2 Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial, Type 1 High Cholesterol Increased Cholesterol Low-Density-Lipoid-Type Hyperlipoproteinemia Pure Hypercholesterolaemia Ldl - [Low Density Lipoprotein} Hyperlipoproteinemia Group A Hyperlipidaemia Pure Hypercholesterinaemia Cholesterolaemia Essential Cholesterolaemia Essential Hypercholesterolaemia Group A Hyperlipemia Increased Low Density Lipoprotein Low-Density-Lipoprotein-Type Low-Density-Lipoprotein-Type Hyperlipoproteinemia
Cerebrovascular Disease	Cerebrovascular Disorder Cerebrovascular Accident Cerebrovascular Disorders Cva Stroke
Apolipoprotein A-Iv Associated Amyloidosis	Aapoaiv Amyloidosis Renal Aapoaiv Amyloidosis Apolipoprotein A-Iv Amyloidosis
Nonobstructive Coronary Artery Disease	Non-Cad Non-Obstructive Coronary Artery Disease
Peripheral Vascular Disease	Peripheral Arterial Disease Arterial Occlusive Disease Arterial Occlusive Diseases Pad Peripheral Vascular Diseases Peripheral Occlusive Disease Peripheral Arterial Diseases Helicobacter Infections
Budd-Chiari Syndrome	Hepatic Vein Thrombosis Chiari Syndrome BDCHS Membranous Obstruction Of The Inferior Vena Cava Budd-Chiari Syndrome, Somatic Movc Budd-Chiari Syndrome, Susceptibility To, Somatic Budd-Chiari Syndrome, Susceptibility To Membranous Obstruction Of Inferior Vena Cava Hepatic Vein Block Obstruction Of Hepatic Veins Hepatic Vein Obstruction Hepatic Venous Block
Prediabetes Syndrome	Prediabetes Impaired Glucose Tolerance Prediabetic State IGT Igt - [Impaired Glucose Tolerance] Impaired Glucose Tolerance With Unspecified Complication Impaired Glucose Tolerance Without Complication Abnormal Glucose Tolerance
Psoriatic Arthritis	Psoriatic Arthritis, Susceptibility To Psoriatic Arthropathy Arthropathic Psoriasis Arthritis, Psoriatic Arthritis Psoriatica PSORAS Arthritic Psoriasis Psoriasis Arthropathica Arthritis Psoriatic Arthritis, Psoriatic, Susceptibility To
Hyperlipoproteinemia, Type I	Lipoprotein Lipase Deficiency Familial Chylomicronemia Syndrome Lpl Deficiency Hyperchylomicronemia, Familial Hyperlipemia, Idiopathic, Burger-Grutz Type Hyperlipemia, Essential Familial Lipase D Deficiency Lipd Deficiency Hyperlipoproteinemia, Type Ia Chylomicronemia, Familial High Density Lipoprotein Cholesterol Level Qtl 11 Hyperlipoproteinemia Type 1 Hyperlipoproteinemia 1 HLPP1 Lipoprotein Lipase Hyperlipoproteinemia Type I Familial Hyperchylomicronemia Syndrome
Tobacco Addiction	Nicotine Dependence Tobacco Addiction, Susceptibility To Nicotine Addiction Tobacco Use Disorder Smoking Habit Nicotine Dependence, Protection Against Nicotine Addiction, Protection From Cigarette Habituation Cigarette Habituation, Susceptibility To Smoking Habit, Susceptibility To Nicotine Dependence, Susceptibility To Nicotine Addiction, Susceptibility To Addiction, Tobacco, Susceptibility To Compulsive Tobacco User Syndrome Tobacco Dependence Tobacco Dependence Syndrome Cigarette Addiction Cigarette Dependence Smoking Addiction Smokers Syndrome
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Myelitis	Spinal Cord Inflammation Nos Radiculomyelitis Nos Myeloradiculitis
Acquired Immunodeficiency Syndrome	Acquired Immune Deficiency Syndrome AIDS Acquired Immune Deficiency Acquired Immunodeficiency Acquired Immunodeficiency Due To Protein Loss
Childhood Testicular Germ Cell Tumor	Paediatric Testicular Germ Cell Neoplasm Paediatric Testicular Germ Cell Tumour Pediatric Testicular Germ Cell Neoplasm Pediatric Testicular Germ Cell Tumor Testicular Germ Cell Tumor, Pediatric
Immunoglobulin Light Chain Amyloidosis	Al Amyloidosis Primary Amyloidosis Primary Systemic Amyloidosis Light Chain Amyloidosis Amyloidosis Al Amyloidosis Primary Systemic Primary Al Amyloidosis Primary Systemic Al Amyloidosis Systemic Al Amyloidsis Systemic Al Amyloidosis Light-Chain Amyloidosis Alys Amyloidosis Familial Amyloid Nephropathy Due To Lysozyme Variant Familial Renal Amyloidosis Due To Lysozyme Variant Hereditary Amyloid Nephropathy Due To Lysozyme Variant Hereditary Renal Amyloidosis Due To Lysozyme Variant Lysozyme Amyloidosis Amyloidosis Primary Immunoglobulin Deposition Disease Immunoglobulinic Amyloidosis Amyloid Al
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Silent Myocardial Infarction
Sitosterolemia	Phytosterolemia Beta-Sitosterolemia Plant Sterol Storage Disease Phytosterolæmia Sitosterolæmia Retention Of Dietary Cholesterol And Abnormal Retention Of Non-Cholesterol Sterols In The Body Phytosterolaemia Sitosterolaemia Sitosterolemia With Xanthomatosis
Amyloidosis, Finnish Type	Finnish Type Amyloidosis Meretoja Syndrome Amyloidosis V Amyloidosis, Meretoja Type Amyloid Cranial Neuropathy With Lattice Corneal Dystrophy Lattice Corneal Dystrophy Type Ii Familial Amyloidosis, Finnish Type Familial Amyloid Polyneuropathy Type Iv Amyloidosis Due To Mutant Gelsolin Agel Amyloidosis Gelsolin Amyloidosis Hereditary Gelsolin Amyloidosis Lattice Corneal Dystrophy Type Ii Finnish Gelsolin-Related Amyloidosis Kymenlaakso Syndrome Lattice Corneal Dystrophy, Gelsolin Type Hereditary Amyloidosis, Finnish Type Lattice Corneal Dystrophy Type 2 Amyloidosis 5 AMYL5 Agel Familial Amyloidosis Finnish Type Meretoja Type Amyloidosis Type Iv Familial Amyloid Polyneuropathy Familial Amyloid Polyneuropathy, Type V Familial Amyloid Polyneuropathy, Type Iv
Familial Lipoprotein Lipase Deficiency	Familial Lpl Deficiency Familial Hyperchylomicronemia Hyperlipoproteinemia Type I Familial Hyperlipoproteinemia Type I Hyperchylomicronemia Burger-Grutz Syndrome Endogenous Hypertriglyceridaemia Familial Fat-Induced Hypertriglyceridemia Lipd Deficiency Lpl Deficiency Lipase D Deficiency Lipoprotein Lipase Deficiency, Familial Familial Chylomicronemia Syndrome Fredrickson Type I Hyperlipoproteinemia Fredrickson Type I Lipaemia Hypercholesterinaemic Xanthomatosis Mixed Hyperglyceridemia Lipoprotein Lipase Deficiency Type I Hyperlipoproteinemia Hyperlipoproteinemia Type Ia Familial Hyperlipo-Proteinemia Type 1
Hypobetalipoproteinemia, Familial, 2	Familial Hypobetalipoproteinemia 2 FHBL2 Hypolipidemia, Familial, Combined Combined Familial Hypolipidemia Combined Hypobetalipoproteinemia Familial Hypobetalipoproteinemia, Familial, Type 2
Pulmonary Coin Lesion	Coin Lesion Of Lung Solitary Pulmonary Nodule Coin Lesion Lung
Intermediate Coronary Syndrome	Unstable Angina Angina At Rest Anginal Chest Pain At Rest Impending Infarction Preinfarction Angina Worsening Angina Angina, Unstable Myocardial Preinfarction Syndrome Angina Unstable Crescendo Angina Angina Decubitus Acute Coronary Insufficiency Unstable Angina Pectoris Preinfarctional Angina Pectoris Worsening Effort Angina Preinfarction Syndrome Unstable Angina Pectoris Syndrome Unstable Anginal Attack Unstable Cardiac Angina Unstable Chest Angina Unstable Heart Angina De Novo Effort Angina Pectoris Crescendo Angina Pectoris Ua - [Unstable Angina]
Alagille Syndrome 1	Alagille Syndrome Arteriohepatic Dysplasia Alagille-Watson Syndrome Cholestasis With Peripheral Pulmonary Stenosis Hepatic Ductular Hypoplasia Alagille Syndrome Due To A Jag1 Point Mutation ALGS1 Algs Aws Syndromic Bile Duct Paucity Cardiovertebral Syndrome Hepatofacioneurocardiovertebral Syndrome Paucity Of Interlobular Bile Ducts Watson-Miller Syndrome Alagille Syndrome Due To 20p12 Microdeletion Ahd Hepatic Ductular Hypoplasia, Syndromatic Watson Alagille Syndrome Alagille'S Syndrome Alagille Syndrome Due To Del(20)(P12) Alagille Syndrome Due To Monosomy 20p12 Alagille-Watson Syndrome Due To Monosomy 20p12 Arteriohepatic Dysplasia Due To Monosomy 20p12 Syndromic Bile Duct Paucity Due To Monosomy 20p12 Alagille-Watson Syndrome Due To A Jag1 Point Mutation Arteriohepatic Dysplasia Due To A Jag1 Point Mutation Syndromic Bile Duct Paucity Due To A Jag1 Point Mutation Alagille Syndrome, Type 1
Corneal Degeneration	Degenerative Corneal Opacity
Carotid Artery Disease	Carotid Artery Diseases Disorder Of Carotid Artery
Prader-Willi Syndrome	Prader-Labhart-Willi Syndrome PWS Willi-Prader Syndrome Prader-Willi Syndrome Due To Translocation Prader-Willi Syndrome Due To Imprinting Mutation Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15 Prader Willi Syndrome Upd(15)Mat
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Deafness, Autosomal Recessive 74	DFNB74 Autosomal Recessive Nonsyndromic Deafness 74 Autosomal Recessive Deafness 74 Deafness, Autosomal Recessive, 74 Deafness, Autosomal Recessive, Type 74
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Arteries, Anomalies Of	Artery Disease Arteriopathic Disease
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Aortic Valve Disease 1	Aortic Valve Disease Bicuspid Aortic Valve Aortic Valve Disorder AOVD1 Bav Bicuspid Aortic Valve Disease Familial Bicuspid Aortic Valve Aortic Valve Calcification Aovd Aortic Valve, Bicuspid Aortic Valve, Calcification Of Aortic Stenosis, Calcific Familial Bav Calcific Aortic Stenosis Calcification Of Aortic Valve Abnormality Of The Aortic Valve Aortic Valve Disease, Type 1 Aortic Valve Disease 2 Bicommissural Aortic Valve
Asymmetric Motor Neuropathy
Ichthyosis, Congenital, Autosomal Recessive 4a	Ichthyosis Congenita Iib Icr2b Autosomal Recessive Congenital Ichthyosis 4a ARCI4A Lamellar Ichthyosis 2 Li2 Ichthyosis, Lamellar, 2, Formerly Li2, Formerly Ichthyosis Lamellar 2 Lamellar Ichthyosis, Type 2 Ichthyosis, Lamellar 2 Ichthyosis, Congenital, Autosomal Recessive, Type 4a
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Cardiomyopathy, Dilated, 1m	Dilated Cardiomyopathy 1m CMD1M Cardiomyopathy, Dilated 1m Cardiomyopathy, Dilated, Type 1m
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13031	GW 841819X	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	APOA1	VGNC	VGNC:37991
Mus musculus	APOA1	MGD	MGI:88049
Felis catus	APOA1	VGNC	VGNC:67771
Bos taurus	APOA1	VGNC	VGNC:26022
Macaca mulatta	APOA1	VGNC	VGNC:99545
Rattus norvegicus	APOA1	RGD	RGD:2130
Others	APOA1	NCBI