GW 841819X
Based on 1 publication(s) in Google Scholar
GW 841819X is a benzodiazepine inhibitor of bromodomains of the BET family (BRD2, BRD3, BRD4) that inhibits the binding of Diazepam to central GABA receptors. GW 841819X can be used in the research of BET bromodomain-related diseases, such as cancer.
For research use only. We do not sell to patients.
- CAS No.: 146135-18-4
- Formula: C25H21N5O2
- Molecular Weight:423.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Publications Citing Use of MedChemExpress (MCE) GW 841819X
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Biological Activity
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apoA1 |
BRD2 |
BRD3 |
BRD4 |
IL-6 |
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Cell Line
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Type | Value | Description | References |
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| HepG2 | EC50 |
440 nM
Compound: 1, GW841819X
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Induction of human ApoA1 gene expression in stably transfected human HepG2 cells coexpressing luciferase reporter gene after 18 hrs by luminescence assay
Induction of human ApoA1 gene expression in stably transfected human HepG2 cells coexpressing luciferase reporter gene after 18 hrs by luminescence assay
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[PMID: 21568322] |
GW 841819X (compound 7) inhibits purified BRD2, BRD3, and BRD4 bromodomain proteins in fluorescence polarization binding assays, with pIC50 values of 5.9, 6.2, and 6.3, respectively[1].
GW 841819X induces ApoA1 reporter gene activity in stable human HepG2 hepatocytes, with an EC170 of 0.22 μM[1].
GW 841819X inhibits lipopolysaccharide-induced IL-6 production in human peripheral blood mononuclear cells (pIC50 = 6.8), and suppresses the binding of benzodiazepines to central GABA receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 146135-18-4
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Molecular Weight 423.47
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Formula C25H21N5O2
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SMILES
CC1=NN=C2N1C3=CC=CC=C3C(C4=CC=CC=C4)=NC2NC(OCC5=CC=CC=C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GW 841819X Related Classifications
HY-13031 Related Classifications
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