GW 841819X
Based on 1 publication(s) in Google Scholar
GW 841819X is a benzodiazepine inhibitor of bromodomains of the BET family (BRD2, BRD3, BRD4) that inhibits the binding of Diazepam to central GABA receptors. GW 841819X can be used in the research of BET bromodomain-related diseases, such as cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 146135-18-4
- 分子式: C25H21N5O2
- 分子量:423.47
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 GW 841819X
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生物活性
製品説明
IC50 & Target
[1]|
apoA1 |
BRD2 |
BRD3 |
BRD4 |
IL-6 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| HepG2 | EC50 |
440 nM
Compound: 1, GW841819X
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Induction of human ApoA1 gene expression in stably transfected human HepG2 cells coexpressing luciferase reporter gene after 18 hrs by luminescence assay
Induction of human ApoA1 gene expression in stably transfected human HepG2 cells coexpressing luciferase reporter gene after 18 hrs by luminescence assay
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[PMID: 21568322] |
体外実験
GW 841819X (compound 7) inhibits purified BRD2, BRD3, and BRD4 bromodomain proteins in fluorescence polarization binding assays, with pIC50 values of 5.9, 6.2, and 6.3, respectively[1].
GW 841819X induces ApoA1 reporter gene activity in stable human HepG2 hepatocytes, with an EC170 of 0.22 μM[1].
GW 841819X inhibits lipopolysaccharide-induced IL-6 production in human peripheral blood mononuclear cells (pIC50 = 6.8), and suppresses the binding of benzodiazepines to central GABA receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 146135-18-4
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分子量 423.47
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分子式 C25H21N5O2
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SMILES
CC1=NN=C2N1C3=CC=CC=C3C(C4=CC=CC=C4)=NC2NC(OCC5=CC=CC=C5)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GW 841819X 関連分類
HY-13031 関連分類
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