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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
ceramide synthesis
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "ceramide synthesis" in MCE Product Catalog:
5
1
1 Cited Publications
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HPA-12 is a blood-brain barrier-permeable small-molecule inhibitor of ceramide transfer protein (CERT) with four stereoisomers (the (1R,3R)-stereoisomer exhibits the highest activity). HPA-12 blocks the transport of ceramide from the endoplasmic reticulum to the Golgi apparatus by binding to the START domain of CERT, leading to intracellular ceramide accumulation and inhibition of sphingomyelin (SM) synthesis. HPA-12 induces endoplasmic reticulum stress via the GRP78/ATF6/CHOP axis and activates mitochondrial autophagy, thereby inhibiting cell growth and inducing apoptosis. In in vivo experiments, HPA-12 significantly reduces the leukemia burden and splenomegaly in mouse models of acute myeloid leukemia (AML) and prolongs survival. HPA-12 is applicable for the research of lipid metabolism in acute myeloid leukemia and Alzheimer's disease .
Cat. No.: HY-D1612
CAS No.: 133867-53-5
Cat. No.: HY-165099
CAS No.: 158983-53-0
Cat. No.: HY-D1735
CAS No.: 571186-05-5
Synonyms: Golgi-Red Tracke
Cat. No.: HY-W014983
CAS No.: 141-12-8
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Cat. No.: HY-128753S6
CAS No.: 288846-88-8
Cat. No.: HY-131701
CAS No.: 109785-20-8
Synonyms: C18 Lactosyl(β) ceramide; Lactosyl Sphingosine; Lyso-Lactosylceramide (synthetic)
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Lactosyl-C18-sphingosine (C18 Lactosyl(β) Ceramide; Lactosyl Sphingosine) is a bioactive sphingolipid that is a form of lactosylceramide but lacks the fatty acyl group. Lysolactosylceramide (1-50 μM) reduces the viability of human neutrophils in a concentration-dependent manner. Unlike lactosylceramide, Lactosyl-C18-sphingosine has no effect on protein synthesis and cell proliferation in cardiomyocytes. Lactosyl-C18-sphingosine is a lysoganglioside GM3.
Cat. No.: HY-W014983R
CAS No.: 141-12-8
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Cat. No.: HY-128753S7
Cat. No.: HY-128753R
CAS No.: 1114-34-7
Cat. No.: HY-128753S3
CAS No.: 70849-22-8
Cat. No.: HY-128753S4
CAS No.: 83379-39-9
Cat. No.: HY-128753S5
CAS No.: 139657-61-7
Cat. No.: HY-181943
CAS No.: 2035011-97-1
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SPT-IN-2 is an orally active serine palmitoyltransferase (SPT) inhibitor (with an IC50 of 0.71 nM against human SPT2). SPT-IN-2 inhibits ceramide synthesis, suppresses cancer cell growth, and exhibits in vivo anti-tumor activity, favorable metabolic stability and cell membrane permeability in xenograft mouse models. SPT-IN-2 blocks the de novo sphingolipid synthesis pathway, significantly reducing intracellular ceramide levels and the levels of 3-ketodihydrosphingosine (3-KDS), the immediate downstream product of SPT. SPT-IN-2 can be used in research related to lung adenocarcinoma, acute promyelocytic leukemia and breast cancer .
Cat. No.: HY-N10706
CAS No.: 16105-69-4
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
