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heart mitochondria

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Akt (3) Apoptosis (4) Autophagy (3) Bacterial (1) Biochemical Assay Reagents (1) Carnitine Palmitoyltransferase (CPT) (1) Endogenous Metabolite (3) Environmental Pollutants (1) ERK (1) GABA Receptor (1) Herbicide (1) JNK (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (3) mTOR (2) Na+/Ca2+ Exchanger (1) p38 MAPK (1) Parasite (3) PI3K (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (6) Infection (4) Inflammation/Immunology (1) Metabolic Disease (5) Neurological Disease (4)
Oligonucleotides:	Cationic Lipids (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0714

Tetrazolium Red 5+ Cited Publications 2,3,5-Triphenyltetrazolium chloride; TPTZ; TTC	Biochemical Assay Reagents	Cardiovascular Disease
Tetrazolium Red (2,3,5-Triphenyltetrazolium chloride; TTC) is a not brain-penetrant, colorless, water-soluble dye that is reduced by mitochondrial enzymes to a deep red, water-insoluble compound (formazan) mainly in the mitochondria of living cells. Tetrazolium Red is used to observe the activity of dehydrogenase, and it turns colorless to red when exposed to hydrogen. Tetrazolium Red distinguishes between surviving and infarcted brain tissue after stroke. Tetrazolium Red has been used to stain heart tissue to measure the extent of acute lesions and also used to stain brain tissue to detect the size of the infarcted area. The absorption wavelength of Tetrazolium Red is 570 nm .

HY-134238

Cardiolipin (Heart, Bovine) sodium 1 Publications Verification	Endogenous Metabolite Mitochondrial Metabolism Apoptosis Autophagy	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Cardiolipin (Heart, Bovine) sodium is a mitochondria-exclusive phospholipid that can be extracted from Bovine hear. Cardiolipin (Heart, Bovine) sodium can maintain mitochondrial function, regulate cellular metabolism and signaling and induce apoptosis and autophagy. Cardiolipin (Heart, Bovine) sodium can be coated on microtitre plates for ELISA assay. Cardiolipin (Heart, Bovine) sodium can be used for the researches of inflammation, immunology, cardiovascular and neurological disease .

HY-15754

CGP37157 Maximum Cited Publications 9 Publications Verification	Na+/Ca2+ Exchanger	Neurological Disease Cancer
CGP37157 is a potent, selective inhibitor of Na ⁺/Ca ²⁺ exchanger, inhibiting the Na ⁺-induced Ca ²⁺-release from guinea-pig heart mitochondria, with an IC₅₀ of 0.8 μM.

HY-129460

XJB-5-131 5+ Cited Publications	Reactive Oxygen Species (ROS)	Neurological Disease
XJB-5-131 is a mitochondria-targeted ROS and electron scavenger . XJB-5-131 is a bi-functional antioxidant that comprises a radical scavenger. XJB-5-131 is a synthetic antioxidant that targets mitochondria . XJB-5-131 is an effective ionizing irradiation protector and mitigator of cord blood mononuclear cells (CB MNCs) .

HY-N0107

Cyclovirobuxine D 1 Publications Verification	Apoptosis Autophagy mTOR Akt	Cardiovascular Disease
Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR . Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis . Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction .

HY-B0817

Pyridaben 1 Publications Verification	Environmental Pollutants Parasite	Infection
Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC₅₀ value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function .

HY-113006

3-Methylglutarylcarnitine	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Cancer
3-Methylglutarylcarnitine is a biomarker of disease associated with compromised mitochondrial energy metabolism .

HY-B0817S

Pyridaben-d13	Parasite	Infection
Pyridaben-d₁₃ is the deuterium labeled Pyridaben . Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC₅₀ value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function .

HY-B0817R

Pyridaben (Standard)	Reference Standards Parasite	Infection
Pyridaben (Standard) is the analytical standard of Pyridaben. This product is intended for research and analytical applications. Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC₅₀ value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function .

HY-N0107R

Cyclovirobuxine D (Standard)	Reference Standards Apoptosis Autophagy mTOR Akt	Cardiovascular Disease
Cyclovirobuxine D (Standard) is the analytical standard of Cyclovirobuxine D. This product is intended for research and analytical applications. Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR . Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis . Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction .

HY-148441

NDH-1 inhibitor-1	Mitochondrial Metabolism Bacterial	Infection
NDH-1 inhibitor-1 is a NADH-ubiquinone oxidoreductase (NDH-1) inhibitor with a pIC₅₀ of 5.40 in potato tuber mitochondria and a pIC₅₀ of 6.15 in Escherichia coli cell membranes. NDH-1 inhibitor-1 acts on the ubiquinone catalytic site to inhibit enzyme activity. NDH-1 inhibitor-1 can be used to study pathogenic microbial infections or mitochondrial diseases .

HY-156184

Octanoylcarnitine	Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Octanoylcarnitine is an orally active medium-chain acylcarnitine transport intermediate in fatty acid β-oxidation. Octanoylcarnitine is converted to octanoyl-CoA by carnitine acetyltransferase (CrAT), which then generates energy via β-oxidation in mitochondria of the heart and skeletal muscle. Octanoylcarnitine enhances grip strength and treadmill endurance, alleviates lactic acidosis, distributes in muscle and heart tissues, increases free carnitine levels, and mitigates mitochondrial stress. Octanoylcarnitine is associated with long-chain fatty acid metabolism, shows a positive correlation with subcutaneous fat area in patients with metastatic pancreatic ductal adenocarcinoma, and is closely related to central retinal artery occlusion (CRAO) .

HY-W436366

SSR180575	GABA Receptor Mitochondrial Metabolism	Cardiovascular Disease
SSR180575 is a specific and potent peripheral benzodiazepine receptor ligand. SSR180575 irreversibly and specifically binds with high affinity on rat heart mitochondria (K_d = 1.95 nM). SSR180575 can be used in the research of cardiovascular diseases .

HY-125778

Cochlioquinone B	Others	Metabolic Disease
Cochlioquinone is a sesquiterpene metabolite originally isolated from C. miyabeanus. It is a phytotoxin that inhibits root growth of finger millet (E. coracana) and rice plants (O. sativa) by 59.9 and 51.7%, respectively, when used at a concentration of 100 ppm.2 Cochlioquinone B inhibits NADH oxidase and NADH-2,3-dimethoxy-5-pentyl-1,4-benzoquinone reductase from bovine heart mitochondria.

HY-W714183

Dinitramine	Herbicide ERK p38 MAPK JNK PI3K Akt Apoptosis Microtubule/Tubulin	Metabolic Disease
Dinitramine is a herbicide. Dinitramine activates the Erk/P38/JNK/MAPK pathway and inactivates the PI3k/Akt pathway in testicular cells. Dinitramine induces endoplasmic reticulum stress, dysregulation of calcium homeostasis in the cytoplasm and mitochondria, apoptosis, and downregulated expression of cell cycle genes in testicular cells. Dinitramine reduces the viability and proliferation capacity of testicular cells, and inhibits cell division by suppressing the synthesis of tubulin. Dinitramine induces abnormal heart development, inhibited angiogenesis, inflammatory responses, apoptosis, and impaired embryonic growth in zebrafish embryos .

HY-182248

Teglicar chloride ST1326 chloride	Carnitine Palmitoyltransferase (CPT) Acyltransferase	Metabolic Disease
Teglicar chloride (ST1326 chloride) is an orally active, reversible, mixed-type, selective inhibitor of hepatic carnitine palmitoyltransferase I (L-CPT I), with an IC₅₀ of 1.1 μM against rat L-CPT I. Teglicar chloride reduces serum glucose levels. Teglicar chloride exhibits antiketotic activity in normal fasted rats. Teglicar chloride can be used in research related to type 2 diabetes and ketoacidosis .

Cat. No.	Product Name

HY-L155

Mitochondrial Toxicity Compound Library	535 compounds
Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity. MCE contains 535 mitochondrial toxic compounds, which can be used as tool compounds for drug development and disease mechanism research.

Mitochondrial Toxicity Compound Library

535 compounds

Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity.

MCE contains 535 mitochondrial toxic compounds, which can be used as tool compounds for drug development and disease mechanism research.

Cat. No.	Product Name	Type

HY-D0714

Tetrazolium Red 5+ Cited Publications 2,3,5-Triphenyltetrazolium chloride; TPTZ; TTC	Biochemical Assay Reagents
Tetrazolium Red (2,3,5-Triphenyltetrazolium chloride; TTC) is a not brain-penetrant, colorless, water-soluble dye that is reduced by mitochondrial enzymes to a deep red, water-insoluble compound (formazan) mainly in the mitochondria of living cells. Tetrazolium Red is used to observe the activity of dehydrogenase, and it turns colorless to red when exposed to hydrogen. Tetrazolium Red distinguishes between surviving and infarcted brain tissue after stroke. Tetrazolium Red has been used to stain heart tissue to measure the extent of acute lesions and also used to stain brain tissue to detect the size of the infarcted area. The absorption wavelength of Tetrazolium Red is 570 nm .

Tetrazolium Red

5+ Cited Publications

2,3,5-Triphenyltetrazolium chloride; TPTZ; TTC

Biochemical Assay Reagents

Tetrazolium Red (2,3,5-Triphenyltetrazolium chloride; TTC) is a not brain-penetrant, colorless, water-soluble dye that is reduced by mitochondrial enzymes to a deep red, water-insoluble compound (formazan) mainly in the mitochondria of living cells. Tetrazolium Red is used to observe the activity of dehydrogenase, and it turns colorless to red when exposed to hydrogen. Tetrazolium Red distinguishes between surviving and infarcted brain tissue after stroke. Tetrazolium Red has been used to stain heart tissue to measure the extent of acute lesions and also used to stain brain tissue to detect the size of the infarcted area. The absorption wavelength of Tetrazolium Red is 570 nm .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-134238

Cardiolipin (Heart, Bovine) sodium 1 Publications Verification	Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Mitochondrial Metabolism Apoptosis Autophagy
Cardiolipin (Heart, Bovine) sodium is a mitochondria-exclusive phospholipid that can be extracted from Bovine hear. Cardiolipin (Heart, Bovine) sodium can maintain mitochondrial function, regulate cellular metabolism and signaling and induce apoptosis and autophagy. Cardiolipin (Heart, Bovine) sodium can be coated on microtitre plates for ELISA assay. Cardiolipin (Heart, Bovine) sodium can be used for the researches of inflammation, immunology, cardiovascular and neurological disease .

HY-N0107

Cyclovirobuxine D 1 Publications Verification	Cardiovascular Disease Alkaloids Buxaceae Classification of Application Fields Other Alkaloids Plants Disease Research Fields Buxus microphylla S.et Z.var. Sinica Rehd.et Wils.	Apoptosis Autophagy mTOR Akt
Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR . Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis . Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction .

HY-113006

3-Methylglutarylcarnitine	Structural Classification Natural Products Endogenous metabolite Lipid Source Classification	Endogenous Metabolite
3-Methylglutarylcarnitine is a biomarker of disease associated with compromised mitochondrial energy metabolism .

HY-N0107R

Cyclovirobuxine D (Standard)	Structural Classification Alkaloids Buxaceae Other Alkaloids Plants Buxus microphylla S.et Z.var. Sinica Rehd.et Wils.	Reference Standards Apoptosis Autophagy mTOR Akt
Cyclovirobuxine D (Standard) is the analytical standard of Cyclovirobuxine D. This product is intended for research and analytical applications. Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR . Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis . Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction .

HY-125778

Cochlioquinone B	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Others
Cochlioquinone is a sesquiterpene metabolite originally isolated from C. miyabeanus. It is a phytotoxin that inhibits root growth of finger millet (E. coracana) and rice plants (O. sativa) by 59.9 and 51.7%, respectively, when used at a concentration of 100 ppm.2 Cochlioquinone B inhibits NADH oxidase and NADH-2,3-dimethoxy-5-pentyl-1,4-benzoquinone reductase from bovine heart mitochondria.

Cat. No.	Product Name	Chemical Structure

HY-B0817S

Pyridaben-d13
Pyridaben-d₁₃ is the deuterium labeled Pyridaben . Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC₅₀ value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function .

Pyridaben-d13

Pyridaben-d₁₃ is the deuterium labeled Pyridaben . Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC₅₀ value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function .

3-Methylglutarylcarnitine		Cationic Lipids
3-Methylglutarylcarnitine is a biomarker of disease associated with compromised mitochondrial energy metabolism .

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heart mitochondria

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products