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  2. Parasite
  3. Pyridaben

Pyridaben 

Cat. No.: HY-B0817 Purity: 99.55%
COA Handling Instructions

Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function.

For research use only. We do not sell to patients.

Pyridaben Chemical Structure

Pyridaben Chemical Structure

CAS No. : 96489-71-3

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Based on 1 publication(s) in Google Scholar

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Description

Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function[1][2].

IC50 & Target

Mite

 

In Vitro

Pyridaben (0-10 µM; 3 min) selectively inhibits complex I-III in rat brain submitochondrial particles[1].
Pyridaben (0-10 µM; 3 min) leads to marked decrease in respiratory control (IC50 = 1.7 µM) in a dose-dependent manner, in rat brain mitochondria (malate-glutamate as substrate)[1].
Pyridaben (0-10 µM; 3 min) produces a marked decrease in mtNOS functional activity, when malate-glutamate is used as substrate, but not when the substrate is succinate.[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Rat brain submitochondrial particles
Concentration: 0-10 µM
Incubation Time: 3 min
Result: Led to a decrease of NADH-cytochrome reductase activity (complex I-III) and without modification of succinate-cytochrome c reductase activity (complex II-III) and of cytochrome oxidase activity (complex IV)

Cell Viability Assay[1]

Cell Line: Rat brain mitochondria
Concentration: 0-10 µM
Incubation Time: 3 min
Result: Showed a marked and dose-dependent decrease in respiratory control in the presence of malate-glutamate as substrate (IC50=1.7 µM)
Molecular Weight

364.93

Formula

C19H25ClN2OS

CAS No.
SMILES

O=C1C(Cl)=C(SCC2=CC=C(C(C)(C)C)C=C2)C=NN1C(C)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (137.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7403 mL 13.7013 mL 27.4025 mL
5 mM 0.5481 mL 2.7403 mL 5.4805 mL
10 mM 0.2740 mL 1.3701 mL 2.7403 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.85 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.85 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Pyridaben
Cat. No.:
HY-B0817
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