1. Apoptosis
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  2. Apoptosis
    Autophagy
    mTOR
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  3. Cyclovirobuxine D

Cyclovirobuxine D 

Cat. No.: HY-N0107
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Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR. Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis. Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction.

For research use only. We do not sell to patients.

Cyclovirobuxine D Chemical Structure

Cyclovirobuxine D Chemical Structure

CAS No. : 860-79-7

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Description

Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR[1]. Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis[2]. Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction[3].

In Vitro

Cyclovirobuxine D (0-240 µM ;24-72 hours) shows a concentration- and time-dependent reduced cell viability after CVB-D treatment, only 10% MGC-803 cells and 20% MKN28 cells are alive at 72 h after treatment with 240 µM[2].
Cyclovirobuxine D (0-120 µM; 48 hours) arrests the cell cycle of gastric cancer cells at S phase in a concentration-dependent manner[2].
Cyclovirobuxine D (0-120 µM; 48 hours) leads to apoptosis in gastric cancer cells in a concentration-dependent manner, especially early stage apoptosis. Cyclovirobuxine D (0-120 µM; 48 hours) causes apoptosis via up-regulation of the apoptosis- related proteins, cleaved Caspase-3 and ratio of Bax/Bcl-2, in gastric cancer cells[2].

Cell Viability Assay[2]

Cell Line: MGC-803 and MKN28 cells
Concentration: 0, 30, 60, 120 and 240 µM
Incubation Time: 24, 48, 72 hours
Result: Reduced Cell Viability and Colony Formation Ability of Gastric Cancer Cells

Cell Cycle Analysis[2]

Cell Line: MGC-803 and MKN28 cells
Concentration: 0, 30, 60, and 120 µM
Incubation Time: 48 hours
Result: Arrested cell cycle progressions of MGC-803 and MKN28 cells.

Apoptosis Analysis[2]

Cell Line: MGC-803 and MKN28 cells
Concentration: 0, 30, 60, and 120 µM
Incubation Time: 48 hours
Result: Induced apoptosis of MGC-803 and MKN28 cells.

Western Blot Analysis[2]

Cell Line: MGC-803 and MKN28 cells
Concentration: 0, 30, 60, and 120 µM
Incubation Time: 48 hours
Result: Up-regulated cleaved Caspase-3 and Bax and decreased the expression of Bcl-2 expression.
Molecular Weight

402.66

Formula

C₂₆H₄₆N₂O

CAS No.

860-79-7

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Cyclovirobuxine D
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