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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

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human epidermoid carcinoma KB cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cholinesterase (ChE) (1) Drug Derivative (1) Endogenous Metabolite (1)
By Research Areas:	Cancer (5) Inflammation/Immunology (1) Neurological Disease (1)

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Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W278867

trans-3,5-Dimethoxystilbene trans-Pinosylvin dimethyl ether	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
trans-3,5-Dimethoxystilbene (trans-Pinosylvin dimethyl ether) is a natural stilbenoid metabolite. trans-3,5-Dimethoxystilbene acts as an acetylcholinesterase inhibitor with a IC₅₀ of 9 μM against Electrophorus electricus acetylcholinesterase. trans-3,5-Dimethoxystilbene binds to acetylcholinesterase and blocks acetylcholine hydrolysis, thereby increasing acetylcholine levels in the cholinergic synaptic cleft. trans-3,5-Dimethoxystilbene can be used in the research of neurodegenerative diseases such as Alzheimer's disease .

HY-N1261

Scutebarbatine B	Others	Cancer
Scutebarbatine B shows significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, with IC₅₀ values in the range 3.5-8.1 mM ^[1]<

HY-N10206

11-epi-Chaetomugilin I	Endogenous Metabolite	Cancer
11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .

HY-N8036

(2R,3R)-Pterosin L 3-O-β-D-glucopyranoside	Others	Cancer
(2R,3R)-Pterosin L 3-O-β-D-glucopyranoside is an glucoside compound found in the aerial parts of Pteris multifida. (2R,3R)-Pterosin L 3-O-β-D-glucopyranoside shows cytotoxicity against cancer cells. (2R,3R)-Pterosin L 3-O-β-D-glucopyranoside can be used for the research of cancer, such as human epidermoid carcinoma .

HY-N17957

Homoisopogon B	Others	Cancer
Homoisopogon B is a homoisoflavane found in the tubers of Ophiopogon japonicus. Homoisopogon B shows cytotoxic activity against cancer cells. Homoisopogon B can be used for the research of cancer, such as human lung adenocarcinoma and human melanoma .

HY-N19853

Mangiferonic acid	Drug Derivative	Cancer
Mangiferonic acid is a triterpenoid found in the stems of Vatica diospyroides. Mangiferonic acid can be used for cancer research .

trans-3,5-Dimethoxystilbene trans-Pinosylvin dimethyl ether	Structural Classification Stilbenes Classification of Application Fields Leguminosae Plants Inflammation/Immunology Disease Research Fields Astragalus membranaceus (Fisch.) Bunge Source Classification	Cholinesterase (ChE)
trans-3,5-Dimethoxystilbene (trans-Pinosylvin dimethyl ether) is a natural stilbenoid metabolite. trans-3,5-Dimethoxystilbene acts as an acetylcholinesterase inhibitor with a IC₅₀ of 9 μM against Electrophorus electricus acetylcholinesterase. trans-3,5-Dimethoxystilbene binds to acetylcholinesterase and blocks acetylcholine hydrolysis, thereby increasing acetylcholine levels in the cholinergic synaptic cleft. trans-3,5-Dimethoxystilbene can be used in the research of neurodegenerative diseases such as Alzheimer's disease .

Scutebarbatine B	Alkaloids Classification of Application Fields Labiatae Derris robusta Pyridine Alkaloids Plants Disease Research Fields Cancer Source Classification	Others
Scutebarbatine B shows significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, with IC₅₀ values in the range 3.5-8.1 mM ^[1]<

11-epi-Chaetomugilin I	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Cancer Source Classification	Endogenous Metabolite
11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .

(2R,3R)-Pterosin L 3-O-β-D-glucopyranoside	Structural Classification Natural Products Pteridaceae Plants Pteris multifida Poir. Source Classification	Others
(2R,3R)-Pterosin L 3-O-β-D-glucopyranoside is an glucoside compound found in the aerial parts of Pteris multifida. (2R,3R)-Pterosin L 3-O-β-D-glucopyranoside shows cytotoxicity against cancer cells. (2R,3R)-Pterosin L 3-O-β-D-glucopyranoside can be used for the research of cancer, such as human epidermoid carcinoma .

Homoisopogon B	Structural Classification Flavonoids Plants Other Flavonoids Asparagaceae Juss. Source Classification	Others
Homoisopogon B is a homoisoflavane found in the tubers of Ophiopogon japonicus. Homoisopogon B shows cytotoxic activity against cancer cells. Homoisopogon B can be used for the research of cancer, such as human lung adenocarcinoma and human melanoma .

Mangiferonic acid	Triterpenes Structural Classification Terpenoids Vatica diospyroides Symington Plants Dipterocarpaceae Source Classification	Drug Derivative
Mangiferonic acid is a triterpenoid found in the stems of Vatica diospyroides. Mangiferonic acid can be used for cancer research .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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human epidermoid carcinoma KB cells

Inhibitors & Agonists

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