trans-3,5-Dimethoxystilbene
Based on 1 Customer Validation
For research use only. We do not sell to patients.
- Purity: 98.45%
- CAS No.: 21956-56-9
- Formula: C16H16O2
- Molecular Weight:240.30
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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AChE 9 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
1.7 μM
Compound: 12
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Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level
Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level
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[PMID: 26750258] |
| HEK293 | IC50 |
>10 μM
Compound: 12
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Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level
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[PMID: 26750258] |
| HEK293 | IC50 |
3.4 μM
Compound: 12
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Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level
Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level
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[PMID: 26750258] |
| RAW264.7 | IC50 |
0.1 μM
Compound: 1
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inhibitory concentration against PGE-2 production in LPS-stimulated RAW264.7 cells
inhibitory concentration against PGE-2 production in LPS-stimulated RAW264.7 cells
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[PMID: 15501064] |
trans-3,5-Dimethoxystilbene (compound 6) (0.05 μg/mL-1 mg/mL; 120 s) potently inhibits purified acetylcholinesterase from Electrophorus electricus with an IC50 of 9 μM[1].
trans-3,5-Dimethoxystilbene (20 μM; 72 h) is noncytotoxic toward human KB oral epidermoid carcinoma cells[1].
trans-3,5-Dimethoxystilbene (100 µg/mL; 12-48 h) does not exhibit nematicidal activity against pinewood nematodes (Bursaphelenchus xylophilus)[2].
trans-3,5-Dimethoxystilbene is a component unique to Pinus rigida resin[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human KB oral epidermoid carcinoma cells
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Concentration:20 μM
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Incubation Time:72 h
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Result:Showed no cytotoxicity toward KB cells at the tested concentration of 20 μM.
Chemical Information
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CAS No. 21956-56-9
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Appearance Solid
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Molecular Weight 240.30
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Formula C16H16O2
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Color Off-white to light yellow
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SMILES
COC1=CC(=CC(=C1)/C=C/C2=CC=CC=C2)OC
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Synonyms
trans-Pinosylvin dimethyl ether
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (416.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (620 KB)
- English - EN (620 KB)
- Français - FR (620 KB)
- Deutsch - DE (620 KB)
- Norwegian - NO (620 KB)
- Español - ES (620 KB)
- Swedish - SV (620 KB)
- Italian - IT (620 KB)
- Korean - KR (620 KB)
- Portuguese - PT (620 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1615 mL | 20.8073 mL | 41.6146 mL | 104.0366 mL |
| 5 mM | 0.8323 mL | 4.1615 mL | 8.3229 mL | 20.8073 mL | |
| 10 mM | 0.4161 mL | 2.0807 mL | 4.1615 mL | 10.4037 mL | |
| 15 mM | 0.2774 mL | 1.3872 mL | 2.7743 mL | 6.9358 mL | |
| 20 mM | 0.2081 mL | 1.0404 mL | 2.0807 mL | 5.2018 mL | |
| 25 mM | 0.1665 mL | 0.8323 mL | 1.6646 mL | 4.1615 mL | |
| 30 mM | 0.1387 mL | 0.6936 mL | 1.3872 mL | 3.4679 mL | |
| 40 mM | 0.1040 mL | 0.5202 mL | 1.0404 mL | 2.6009 mL | |
| 50 mM | 0.0832 mL | 0.4161 mL | 0.8323 mL | 2.0807 mL | |
| 60 mM | 0.0694 mL | 0.3468 mL | 0.6936 mL | 1.7339 mL | |
| 80 mM | 0.0520 mL | 0.2601 mL | 0.5202 mL | 1.3005 mL | |
| 100 mM | 0.0416 mL | 0.2081 mL | 0.4161 mL | 1.0404 mL |
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