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nitrite production

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By Targets:	Akt (1) AMPK (1) Apoptosis (2) Autophagy (1) Bacterial (1) Caspase (1) Drug Derivative (1) Drug Metabolite (2) FXR (1) G protein-coupled Bile Acid Receptor 1 (2) HDAC (1) Heme Oxygenase (HO) (1) IKK (1) Isocitrate Dehydrogenase (IDH) (1) Keap1-Nrf2 (1) mTOR (1) NF-κB (1) NO Synthase (5) PI3K (1) Quinone Reductase (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2) TNF Receptor (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (10) Metabolic Disease (2) Neurological Disease (3)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N4099

Luteolin-3-O-beta-D-glucuronide	Drug Metabolite	Inflammation/Immunology
Luteolin-3-O-beta-D-glucuronide, a glucuronide derivative of Luteolin (HY-N0162), is found in the leaves of Rosmarinus officinalis L. Luteolin-3-O-beta-D-glucuronide inhibits nitrite production in macrophages and binds strongly to FYN kinase .

HY-131521

Oxalomalic acid trisodium Oxalomalate trisodium	Isocitrate Dehydrogenase (IDH)	Cancer
Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages .

HY-N2556

Tirucallol	Others	Inflammation/Immunology
Tirucallol, a tetracyclic triterpene, is isolated from Euphorbia lacteal latex. Tirucallol has topical anti-inflammatory effect. Tirucallol can suppress ear edema in the mouse model and inhibit nitrite production in lipopolysaccharide-stimulated macrophages .

HY-176779

Guanidino ethyl disulfide	NO Synthase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Guanidino ethyl disulfide (GED) (Compound 23) is a NO Synthase (NOS) inhibitor with EC₅₀s of 110, 630 and 180  μM for iNOS, eNOS and bNOS, respectivly. Guanidino ethyl disulfide effectively inhibits nitrite production in J774.2 macrophages. Guanidino ethyl disulfide can be used for circulatory shock, inflammation and neurological diseases research .

HY-118160

PPM-18 NSC 73233	NO Synthase Drug Derivative IKK NF-κB HDAC Reactive Oxygen Species (ROS) AMPK mTOR PI3K Akt Autophagy Apoptosis	Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology Cancer
PPM-18 (NSC 73233) is a Vitamin K (HY-B2172) analog. PPM-18 prevents LPS-induced IκBα degradation, thereby inhibiting NF-κB activation and nuclear translocation of NF-κB. PPM-18 inhibits LPS-induced nitrite production and iNOS expression. PPM-18 inhibits HDAC6. PPM-18 induces ROS accumulation, activates AMPK, inhibits the mTORC1 and PI3K/AKT pathways, initiates Autophagy, and induces Apoptosis. PPM-18 suppresses seizures in zebrafish and mouse epilepsy models. PPM-18 prevents LPS-induced lethal toxicity and delayed hypotension. PPM-18 exhibits anticancer activity against leukemia and bladder cancer. PPM-18 can be used in research related to septic shock, bladder cancer and atherosclerosis .

HY-N0577R

Apiin (Standard) Apigenin 7-O-apiosylglucoside (Standard); Apigenin 7-(2-O-apiosylglucoside) (Standard)	Reference Standards NO Synthase	Inflammation/Immunology
Apiin (Standard) is the analytical standard of Apiin. This product is intended for research and analytical applications. Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC50 = 0.08 mg/mL) in-vitro and iNOS expression (IC50 = 0.049 mg/ mL) in LPS-activated J774.A1 cells .

HY-172786

Caspase-3-IN-3	Caspase Apoptosis	Metabolic Disease
Caspase-3-IN-3 (compound 7) is a caspase 3 inhibitor. Caspase-3-IN-3 increases cellular ATP levels, inhibits caspase-3 activity, decreases nitrite production, suppresses cytokine-induced apoptosis, and restores Glucose (HY-B0389)-stimulated insulin secretion .

HY-N4099R

Luteolin-3-O-beta-D-glucuronide (Standard)	Reference Standards Drug Metabolite	Inflammation/Immunology
Luteolin-3-O-beta-D-glucuronide (Standard) is the analytical standard of Luteolin-3-O-beta-D-glucuronide (HY-N4099). This product is intended for research and analytical applications. Luteolin-3-O-beta-D-glucuronide, a glucuronide derivative of Luteolin (HY-N0162), is found in the leaves of Rosmarinus officinalis L. Luteolin-3-O-beta-D-glucuronide inhibits nitrite production in macrophages and binds strongly to FYN kinase .

HY-177050

RG-239	G protein-coupled Bile Acid Receptor 1	Metabolic Disease Inflammation/Immunology
RG-239 is an orally active TGR5 agonist with an EC₅₀ of 120 nM, significantly outperforming Betulinic acid (HY-10529) (EC₅₀ = 1.04 μM). RG-239 demonstrates higher selectivity for TGR5 compared to the FXRα. RG-239 increases mitochondrial activity in adipocytes and promotes neurite outgrowth at higher concentrations. RG-239 inhibits LPS (HY-D1056)-induced iNOS expression and nitrite production in Raw264.7 and microglia cells. RG-239 can be used for the study of type 2 diabetes ^{[1][2][3][4][5]}.

HY-101328A

2-Iminopiperidine (hydrochloride)	NO Synthase	Neurological Disease Inflammation/Immunology
2-Iminopiperidine hydrochloride is an orally active inducible nitric oxide synthase inhibitor. 2-Iminopiperidine hydrochloride can be used to investigate NO-mediated arthritis, inflammatory bowel disease, diabetes, allodynia, cerebral ischemia and other central nervous system diseases .

HY-183692

FXR agonist 18	FXR G protein-coupled Bile Acid Receptor 1 TNF Receptor Heme Oxygenase (HO) Quinone Reductase Keap1-Nrf2	Cardiovascular Disease Inflammation/Immunology
FXR agonist 18 is an orally active FXR agonist, with an EC₅₀ of 10 nM against human FXR and an EC₅₀ of 1360 nM against human TGR5. FXR agonist 18 inhibits inflammatory responses by reducing nitrite production, downregulating the expression of pro-inflammatory genes (Tnf, Adgre1, Cyp8b1, upregulating the expression of FXR, Hmox1, Nqo1, Nrf2, and enhancing antioxidant responses. FXR agonist 18 ameliorates liver fibrosis in mice, exhibits protective effects in mice with cholestatic liver injury, and shows anti-MASH efficacy. FXR agonist 18 can be used in studies of metabolic dysfunction-associated steatohepatitis .

HY-N9229

Myricadenin A	NO Synthase Bacterial	Infection Inflammation/Immunology
Myricadenin A is an iNOS inhibitor, capable of effectively inhibiting the production of NO (EC₅₀ = 18.1 μM). Myricadenin A has moderate ABTS free radical scavenging activity (SC₅₀ = 175.4 μM) and relatively weak anti-tuberculosis activity (MIC = 80.0 μg/mL). Myricadenin A can be used in inflammation-related research .

Luteolin-3-O-beta-D-glucuronide	Structural Classification Flavonoids other families Classification of Application Fields Flavones Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Drug Metabolite
Luteolin-3-O-beta-D-glucuronide, a glucuronide derivative of Luteolin (HY-N0162), is found in the leaves of Rosmarinus officinalis L. Luteolin-3-O-beta-D-glucuronide inhibits nitrite production in macrophages and binds strongly to FYN kinase .

Tirucallol	Triterpenes Classification of Application Fields Euphorbia boetica Terpenoids Euphorbiaceae Plants Disease Research Fields Inflammation/Immunology Source Classification	Others
Tirucallol, a tetracyclic triterpene, is isolated from Euphorbia lacteal latex. Tirucallol has topical anti-inflammatory effect. Tirucallol can suppress ear edema in the mouse model and inhibit nitrite production in lipopolysaccharide-stimulated macrophages .

Apiin (Standard) Apigenin 7-O-apiosylglucoside (Standard); Apigenin 7-(2-O-apiosylglucoside) (Standard)	Structural Classification Flavonoids Flavones Phenols Polyphenols Umbelliferae Plants Baccharis sarothroides A.Gray Source Classification	Reference Standards NO Synthase
Apiin (Standard) is the analytical standard of Apiin. This product is intended for research and analytical applications. Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC50 = 0.08 mg/mL) in-vitro and iNOS expression (IC50 = 0.049 mg/ mL) in LPS-activated J774.A1 cells .

Luteolin-3-O-beta-D-glucuronide (Standard)	Structural Classification Flavonoids other families Flavones Phenols Polyphenols Plants Source Classification	Reference Standards Drug Metabolite
Luteolin-3-O-beta-D-glucuronide (Standard) is the analytical standard of Luteolin-3-O-beta-D-glucuronide (HY-N4099). This product is intended for research and analytical applications. Luteolin-3-O-beta-D-glucuronide, a glucuronide derivative of Luteolin (HY-N0162), is found in the leaves of Rosmarinus officinalis L. Luteolin-3-O-beta-D-glucuronide inhibits nitrite production in macrophages and binds strongly to FYN kinase .

Myricadenin A	Structural Classification Natural Products Other Phenylpropanoids Phenylpropanoids Plants Morella adenophora (Hance) J. Herb. Source Classification Myricaceae	NO Synthase Bacterial
Myricadenin A is an iNOS inhibitor, capable of effectively inhibiting the production of NO (EC₅₀ = 18.1 μM). Myricadenin A has moderate ABTS free radical scavenging activity (SC₅₀ = 175.4 μM) and relatively weak anti-tuberculosis activity (MIC = 80.0 μg/mL). Myricadenin A can be used in inflammation-related research .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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nitrite production

Inhibitors & Agonists

NaturalProducts

Natural
Products