2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. Oxalomalic acid trisodium

Oxalomalic acid trisodium  (Synonyms: Oxalomalate trisodium)

Cat. No.: HY-131521
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Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages.

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Oxalomalic acid trisodium Chemical Structure

Oxalomalic acid trisodium Chemical Structure

CAS No. : 89304-26-7

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Oxalomalic acid trisodium Related Antibodies

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Description

Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages[1].

In Vitro

Oxalomalic acid trisodium (2.2, 5 mM; 2+24 h) reduces LPS-induced nitrite production and iNOS protein expression in J774 cells[1].
Oxalomalic acid trisodium (5 mM; 6, 12 h) shows no effect on the expression of iNOS mRNA in LPS-stimulated J774 macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oxalomalic acid trisodium Related Antibodies

Western Blot Analysis[1]

Cell Line: J774 cells
Concentration: 2.2, 5 mM (stimulated with LPS (1 μg/ml))
Incubation Time: 2+24 h
Result: Reduced in a significant and concentration-dependent manner nitrite production, reduced iNOS protein expression.
Molecular Weight

272.05

Formula

C6H3Na3O8
CAS No.
SMILES

O=C(C(C(C(C(O[Na])=O)O)C(O[Na])=O)=O)O[Na]
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Oxalomalic acid trisodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxalomalic acid trisodium89304-26-7Oxalomalate trisodiumIsocitrate Dehydrogenase (IDH)LPSnitriteiNOS proteinJ774 cellsInhibitorinhibitorinhibit

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