2-Iminopiperidine (hydrochloride)
2-Iminopiperidine hydrochloride is an orally active inducible nitric oxide synthase inhibitor. 2-Iminopiperidine hydrochloride can be used to investigate NO-mediated arthritis, inflammatory bowel disease, diabetes, allodynia, cerebral ischemia and other central nervous system diseases.
For research use only. We do not sell to patients.
- CAS No.: 16011-96-4
- Formula: C5H11ClN2
- Molecular Weight:134.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
2-Iminopiperidine (compound 13) (15 minute) hydrochloride inhibits mouse inducible nitric oxide synthase (IC50 = 0.6 μM) and rat brain constitutive nitric oxide synthase (IC50 = 2.0 μM) in vitro[1].
2-Iminopiperidine (1h pre-incubation on ice; 1h incubation at 37°C) hydrochloride inhibits nitrite production by LPS-induced RAW 264.7 cells (IC50 = 14 μM) in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats (systemic hypotension/toxic shock induced by intraperitoneal injection of 10 mg/kg LPS)[1]
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Dosage:1; 10; 100 mg/kg
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Administration:p.o.
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Result:Dose-dependently decreased the LPS-induced rise in plasma nitrites (a marker of nitric oxide production).
Chemical Information
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CAS No. 16011-96-4
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Molecular Weight 134.61
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Formula C5H11ClN2
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SMILES
NC1=NCCCC1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Iminopiperidine (hydrochloride) Related Classifications
HY-101328A Related Classifications
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