2. Immunology/Inflammation
  3. NO Synthase
  4. 2-Iminopiperidine (hydrochloride)

2-Iminopiperidine hydrochloride is an orally active inducible nitric oxide synthase inhibitor. 2-Iminopiperidine hydrochloride can be used to investigate NO-mediated arthritis, inflammatory bowel disease, diabetes, allodynia, cerebral ischemia and other central nervous system diseases.

For research use only. We do not sell to patients.

2-Iminopiperidine (hydrochloride)

2-Iminopiperidine (hydrochloride) Chemical Structure

CAS No. : 16011-96-4

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2-Iminopiperidine (hydrochloride) Related Antibodies

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Description

2-Iminopiperidine hydrochloride is an orally active inducible nitric oxide synthase inhibitor. 2-Iminopiperidine hydrochloride can be used to investigate NO-mediated arthritis, inflammatory bowel disease, diabetes, allodynia, cerebral ischemia and other central nervous system diseases[1].

In Vitro

2-Iminopiperidine (compound 13) (15 minute) hydrochloride inhibits mouse inducible nitric oxide synthase (IC50 = 0.6 μM) and rat brain constitutive nitric oxide synthase (IC50 = 2.0 μM) in vitro[1].
2-Iminopiperidine (1h pre-incubation on ice; 1h incubation at 37°C) hydrochloride inhibits nitrite production by LPS-induced RAW 264.7 cells (IC50 = 14 μM) in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Iminopiperidine (hydrochloride) Related Antibodies
In Vivo

2-Iminopiperidine (compound 13) (1-100 mg/kg; p.o.) hydrochloride inhibits LPS-induced nitric oxide production in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (systemic hypotension/toxic shock induced by intraperitoneal injection of 10 mg/kg LPS)[1]
Dosage: 1; 10; 100 mg/kg
Administration: p.o.
Result: Dose-dependently decreased the LPS-induced rise in plasma nitrites (a marker of nitric oxide production).
Molecular Weight

134.61

Formula

C5H11ClN2
CAS No.
SMILES

NC1=NCCCC1.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2-Iminopiperidine (hydrochloride) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Iminopiperidine (hydrochloride)16011-96-4NO SynthaseNitric oxide synthasesNOSnitrite productionratsplasma nitritessystemic hypotensioninflammatory bowel diseaseconstitutive nitric oxide synthaseRAW 264.7 cellsseptic shockinducible nitric oxide synthaseLPSInhibitorinhibitorinhibit

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