Pempidine
Based on 1 Customer Validation
Pempidine (1,2,2,6,6-Pentamethylpiperidine) is an orally active ganglionic blocking agent used in hypertension-related conditions. Pempidine is a nicotinic receptor blocker. Pempidine can antagonize the nicotine-induced increase of the striatal dopamine (DA) in vitro.
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- Purity : 99.96%
- CAS No.: 79-55-0
- 화학식: C10H21N
- 분자량:155.28
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보관:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
In Vivo
Pempidine (1 mg/kg, p.o., single dose) passes rapidly into the erythrocytes in rat model[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male NMRI mice (20-30 g)[3]
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Dosage:0.6 and 20 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Inhibited the nicotine-induced hypothermia.
Antagonized totally the nicotine-induced increase of the DOPAC content.
Chemical Information
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CAS No. 79-55-0
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Appearance Liquid (Density: 0.858 g/cm3 )
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분자량 155.28
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화학식 C10H21N
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Color Colorless to off-white
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SMILES
CC1(C)CCCC(C)(C)N1C
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Synonyms
1,2,2,6,6-Pentamethylpiperidine
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 100 mg/mL (644.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.10 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.10 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (273 KB)
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SDS (631 KB)
- English - EN (631 KB)
- Français - FR (631 KB)
- Deutsch - DE (631 KB)
- Norwegian - NO (631 KB)
- Español - ES (631 KB)
- Swedish - SV (631 KB)
- Italian - IT (631 KB)
- Korean - KR (631 KB)
- Portuguese - PT (631 KB)
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Handling Instructions (2659 KB)
References
[1]. Martin TJ, et al. Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine. J Pharmacol Exp Ther. 1990 Jul;254(1):45-51. [Content Brief]
[3]. Haikala, H., & Ahtee, L. (1988). Antagonism of the nicotine-induced changes of the striatal dopamine metabolism in mice by mecamylamine and pempidine. Naunyn-Schmiedeberg's archives of pharmacology, 338(2), 169–173. [Content Brief]
[4]. MUGGLETON, D. F., & READING, H. W. (1959). Absorption, metabolism and elimination of pempidine in the rat. British journal of pharmacology and chemotherapy, 14(2), 202–208. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.4400 mL | 32.1999 mL | 64.3998 mL | 160.9995 mL |
| 5 mM | 1.2880 mL | 6.4400 mL | 12.8800 mL | 32.1999 mL | |
| 10 mM | 0.6440 mL | 3.2200 mL | 6.4400 mL | 16.0999 mL | |
| 15 mM | 0.4293 mL | 2.1467 mL | 4.2933 mL | 10.7333 mL | |
| 20 mM | 0.3220 mL | 1.6100 mL | 3.2200 mL | 8.0500 mL | |
| 25 mM | 0.2576 mL | 1.2880 mL | 2.5760 mL | 6.4400 mL | |
| 30 mM | 0.2147 mL | 1.0733 mL | 2.1467 mL | 5.3666 mL | |
| 40 mM | 0.1610 mL | 0.8050 mL | 1.6100 mL | 4.0250 mL | |
| 50 mM | 0.1288 mL | 0.6440 mL | 1.2880 mL | 3.2200 mL | |
| 60 mM | 0.1073 mL | 0.5367 mL | 1.0733 mL | 2.6833 mL | |
| 80 mM | 0.0805 mL | 0.4025 mL | 0.8050 mL | 2.0125 mL | |
| 100 mM | 0.0644 mL | 0.3220 mL | 0.6440 mL | 1.6100 mL |
Pempidine Related Classifications
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