79-55-0
79-55-0
Chemical Structure
Pempidine
Synonym(s): 1,2,2,6,6-Pentamethylpiperidine
- CAS No.: 79-55-0
- Formula:C10H21N
- Molecular Weight:155.28
IUPAC Name: 1,2,2,6,6-pentamethylpiperidine
InChIKey: XULIXFLCVXWHRF-UHFFFAOYSA-N
SMILES: CC1(C)CCCC(C)(C)N1C
Biological Activity: Pempidine (1,2,2,6,6-Pentamethylpiperidine) is an orally active ganglionic blocking agent used in hypertension-related conditions. Pempidine is a nicotinic receptor blocker. Pempidine can antagonize the nicotine-induced increase of the striatal dopamine (DA) in vitro[1][2][3][4].
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Pempidine | 99.96% | Pempidine (1,2,2,6,6-Pentamethylpiperidine) is an orally active ganglionic blocking agent used in hypertension-related conditions. Pempidine is a nicotinic receptor blocker. Pempidine can antagonize the nicotine-induced increase of the striatal dopamine (DA) in vitro. | ||||||||||||||||||||
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References
- [1]. Martin TJ, et al. Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine. J Pharmacol Exp Ther. 1990 Jul;254(1):45-51. [Content Brief]
- [2]. L. BRETHERICK, Congeners of Pempidine with High Ganglion-blocking Activity. Nature, 1959, 184: 1707-1709 )
- [3]. Haikala, H., & Ahtee, L. (1988). Antagonism of the nicotine-induced changes of the striatal dopamine metabolism in mice by mecamylamine and pempidine. Naunyn-Schmiedeberg's archives of pharmacology, 338(2), 169–173. [Content Brief]
- [4]. MUGGLETON, D. F., & READING, H. W. (1959). Absorption, metabolism and elimination of pempidine in the rat. British journal of pharmacology and chemotherapy, 14(2), 202–208. [Content Brief]
Keywords
