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A 1120 

Cat. No.: HY-107633 Purity: 99.81%
Handling Instructions

A 1120 is a high-affinity nonretinoid retinol-binding protein 4 (RBP4) antagonist with a Ki value of 8.3 nM. A 1120 disrupts the interaction between RBP4 and its binding partner transthyretin.

For research use only. We do not sell to patients.

A 1120 Chemical Structure

A 1120 Chemical Structure

CAS No. : 1152782-19-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 121 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 380 In-stock
Estimated Time of Arrival: December 31
50 mg USD 650 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

A 1120 is a high-affinity nonretinoid retinol-binding protein 4 (RBP4) antagonist with a Ki value of 8.3 nM. A 1120 disrupts the interaction between RBP4 and its binding partner transthyretin[1][2].

IC50 & Target

Ki: 8.3 nM (Retinol-binding protein 4)[1]

In Vitro

The IC50 of A 1120 is 90 nM on human RBP4 and 66 nM on mouse RBP4[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

392.37

Formula

C₂₀H₁₉F₃N₂O₃

CAS No.
SMILES

FC(F)(C1=C(C2CCN(C(NC3=C(C=CC=C3)C(O)=O)=O)CC2)C=CC=C1)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (254.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5486 mL 12.7431 mL 25.4861 mL
5 mM 0.5097 mL 2.5486 mL 5.0972 mL
10 mM 0.2549 mL 1.2743 mL 2.5486 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.37 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.81%

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

A 1120A1120A-1120OthersInhibitorinhibitorinhibit

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A 1120
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HY-107633
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