1152782-19-8
1152782-19-8
Chemical Structure
A 1120
- CAS No.: 1152782-19-8
- Formula:C20H19F3N2O3
- Molecular Weight:392.37
IUPAC Name: 2-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid
InChIKey: MEAQCLPMSVEOQF-UHFFFAOYSA-N
SMILES: FC(F)(C1=C(C2CCN(C(NC3=C(C=CC=C3)C(O)=O)=O)CC2)C=CC=C1)F
Biological Activity: A 1120 is a high-affinity nonretinoid retinol-binding protein 4 (RBP4) antagonist with a Ki value of 8.3 nM. A 1120 disrupts the interaction between RBP4 and its binding partner transthyretin[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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A 1120 | 99.73% | A 1120 is a high-affinity nonretinoid retinol-binding protein 4 (RBP4) antagonist with a Ki value of 8.3 nM. A 1120 disrupts the interaction between RBP4 and its binding partner transthyretin. | ||||||||||||||||||||
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A 1120 (Standard) | A 1120 (Standard) is the analytical standard of A 1120 (HY-107633). This product is intended for research and analytical applications. A 1120 is a high-affinity nonretinoid retinol-binding protein 4 (RBP4) antagonist with a Ki value of 8.3 nM. A 1120 disrupts the interaction between RBP4 and its binding partner transthyretin. | |||||||||||||||||||||
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References
- [1]. Motani A, et al. Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J Biol Chem. 2009 Mar 20;284(12):7673-80. [Content Brief]
- [2]. Dobri N, et al. A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis. Invest Ophthalmol Vis Sci. 2013 Jan 7;54(1):85-95. [Content Brief]
