2. Disease Areas
  3. Neurological, Eye or Ear Disease
  4. Pain
  5. Mechanical Allodymia

Mechanical Allodymia

Mechanical allodynia is a type of neuropathic pain characterized by pain from normally non-painful mechanical stimuli, such as light touch, and is commonly associated with nerve damage seen in conditions like diabetes, representing a significant clinical challenge with limited biological benefit.

Mechanical Allodymia (6):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-164795
    SBI-810 1849603-79-7 98.25%
    SBI-810 is a blood-brain barrier-permeable NTSR1 modulator. SBI-810 promotes the recruitment of β-arrestin-2 to NTSR1 and antagonizes NTSR1-mediated Gq activation. SBI-810 inhibits excitatory synaptic transmission, NMDA receptor and extracellular signal-regulated kinase (ERK) signaling in spinal nociceptive neurons, reduces surface expression of Nav1.7 and action potential firing in primary sensory neurons, and attenuates C-fiber responses. SBI-810 effectively alleviates acute and chronic pain in various rodent models through peripheral and central modulation. SBI-810 is applicable to research related to multiple pain disorders.
    SBI-810
  • HY-164795A
    SBI-810 hydrochloride 2772746-58-2 99.55%
    SBI-810 hydrochloride is a blood-brain barrier-permeable NTSR1 modulator. SBI-810 hydrochloride promotes the recruitment of β-arrestin-2 to NTSR1 and antagonizes NTSR1-mediated Gq activation. SBI-810 hydrochloride inhibits excitatory synaptic transmission, NMDA receptor and extracellular signal-regulated kinase (ERK) signaling in spinal nociceptive neurons, reduces surface expression of Nav1.7 and action potential firing in primary sensory neurons, and attenuates C-fiber responses. SBI-810 hydrochloride effectively alleviates acute and chronic pain in various rodent models through peripheral and central modulation. SBI-810 hydrochloride is applicable to research related to multiple pain disorders.
    SBI-810 hydrochloride
  • HY-168906
    BI-113823 1119282-90-4 99.23%
    BI-113823 is an orally active, blood-brain barrier-permeable bradykinin B1 receptor antagonist, with a Ki value of 5.3 nM for human receptors and 13.3 nM for rat receptors. BI-113823 reduces inflammation-induced mechanical hyperalgesia, as well as the mechanical sensitivity of peripheral afferent nerves and spinal nociceptive-specific neurons. BI-113823 alleviates liver fibrosis and portal hypertension, and improves survival in chronic liver disease models. BI-113823 inhibits the activities of monocytes, neutrophils and hepatic stellate cells, as well as the PI3K/Akt signaling pathway. BI-113823 can be used in research related to inflammatory pain, liver fibrosis and portal hypertension.
    BI-113823
  • HY-101328A
    2-Iminopiperidine (hydrochloride) 16011-96-4
    2-Iminopiperidine hydrochloride is an orally active inducible nitric oxide synthase inhibitor. 2-Iminopiperidine hydrochloride can be used to investigate NO-mediated arthritis, inflammatory bowel disease, diabetes, allodynia, cerebral ischemia and other central nervous system diseases.
    2-Iminopiperidine (hydrochloride)
  • HY-N18367
    Lemairamin 29946-61-0
    Lemairamin (Wgx-50) is a hydroxylamine compound. Lemairamin can be isolated from the pericarps of the Zanthoxylum plants. Lemairamin activates α7nAChR, stimulates the expression of IL-10 and POMC. Lemairamin shows a decrease in Akt. Lemairamin attenuates DSS-induced intestinal inflammation. Lemairamin alleviates pain hypersensitivity.
    Lemairamin
  • HY-106388A
    Fadolmidine hydrochloride 189353-32-0
    Fadolmidine hydrochloride is a novel, selective α2-adrenoceptor (α2-AR) agonist with EC50 values of 0.4 nM, 4.9 nM and 0.5 nM for 2A, 2B and 2C, respectively. Fadolmidine hydrochloride has been effective against various submodalities of pain such as heat pain, mechanical pain, and visceral pain. Fadolmidine hydrochloride inhibits also electrically evoked contractions in rat vas deferens.
    Fadolmidine hydrochloride