29946-61-0
29946-61-0
Chemical Structure
Lemairamin
Synonym(s): Wgx-50
- CAS No.: 29946-61-0
- Formula:C19H21NO3
- Molecular Weight:311.37
InChIKey: YMZWKEYJSYDVKL-PKNBQFBNSA-N
SMILES: O=C(/C=C/C1=CC=CC=C1)NCCC2=CC(OC)=C(C=C2)OC
Biological Activity: Lemairamin (Wgx-50) is a hydroxylamine compound. Lemairamin can be isolated from the pericarps of the Zanthoxylum plants. Lemairamin activates α7nAChR, stimulates the expression of IL-10 and POMC. Lemairamin shows a decrease in Akt. Lemairamin attenuates DSS-induced intestinal inflammation. Lemairamin alleviates pain hypersensitivity[1][2].
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Lemairamin | Lemairamin (Wgx-50) is a hydroxylamine compound. Lemairamin can be isolated from the pericarps of the Zanthoxylum plants. Lemairamin activates α7nAChR, stimulates the expression of IL-10 and POMC. Lemairamin shows a decrease in Akt. Lemairamin attenuates DSS-induced intestinal inflammation. Lemairamin alleviates pain hypersensitivity. | |||||||||||||||||||||
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References
- [1]. Zhang L, et al. Lemairamin (Wgx-50) Attenuates DSS-Induced Intestinal Inflammation in Zebrafish. Int J Mol Sci. 2024;25(17):9510. Published 2024 Sep 1. [Content Brief]
- [2]. Wang ZY, et al. Lemairamin, isolated from the Zanthoxylum plants, alleviates pain hypersensitivity via spinal α7 nicotinic acetylcholine receptors. Biochem Biophys Res Commun. 2020;525(4):1087-1094. [Content Brief]
Keywords
