Lemairamin
Lemairamin (Wgx-50) is a hydroxylamine compound. Lemairamin can be isolated from the pericarps of the Zanthoxylum plants. Lemairamin activates α7nAChR, stimulates the expression of IL-10 and POMC. Lemairamin shows a decrease in Akt. Lemairamin attenuates DSS-induced intestinal inflammation. Lemairamin alleviates pain hypersensitivity.
For research use only. We do not sell to patients.
- CAS No.: 29946-61-0
- Formula: C19H21NO3
- Molecular Weight:311.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-10 |
IL-6 |
IL-1β |
Lemairamin (1-300 mg/kg; s.c.) dose-dependently inhibits formalin-induced tonic pain in male Swiss mice with an Emax of 66.7% inhibition and an ED50 of 11.1 mg/kg, via activation of α7nAChRs[2].
Lemairamin (1-300 mg/kg; s.c.; single administration) dose-dependently inhibits formalin-induced tonic pain in adult Wistar rats with an Emax of 45.9% inhibition and an ED50 of 21.9 mg/kg[2].
Lemairamin (10-300 μg; i.t.; single administration) dose-dependently reduces mechanical allodynia in L5/L6 spinal nerve ligated Wistar rats with an Emax of 60.4% MPE and an ED50 of 83.9 μg, via α7nAChR activation and subsequent stimulation of spinal IL-10 and β-endorphin expression[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:wild-type (WT); Tg(lyz:EGFP) (transgenic for neutrophil labeling; 3-day-post-fertilization; DSS-induced intestinal inflammation)[1]
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Dosage:10 μL/L
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Administration:6, 12, or 18 hours
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Result:Suppressed recruitment of neutrophils to the intestinal injury site, with the most significant reduction observed at 12 hours.
Significantly reduced the relative mRNA expression levels of pro-inflammatory cytokines il-1β, il-6, cxcl8a, and tnf-α, with the most significant reduction at 12 hours.
Preserved intestinal morphology, including intact, well-arranged intestinal epithelial cell structure, normal glandular structure, reduced intestinal vacuoles, alleviated DSS-induced increases in crypt depth, and restored the villus length to crypt depth ratio.
Significantly decreased the relative protein expression of p-Akt/Akt compared to the DSS-only group.
Significantly downregulated the relative mRNA expression levels of akt1, akt2, and akt3, which were upregulated by DSS treatment.
Chemical Information
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CAS No. 29946-61-0
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Molecular Weight 311.37
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Formula C19H21NO3
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SMILES
O=C(/C=C/C1=CC=CC=C1)NCCC2=CC(OC)=C(C=C2)OC
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Synonyms
Wgx-50
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Zhang L, et al. Lemairamin (Wgx-50) Attenuates DSS-Induced Intestinal Inflammation in Zebrafish. Int J Mol Sci. 2024;25(17):9510. Published 2024 Sep 1. [Content Brief]
[2]. Wang ZY, et al. Lemairamin, isolated from the Zanthoxylum plants, alleviates pain hypersensitivity via spinal α7 nicotinic acetylcholine receptors. Biochem Biophys Res Commun. 2020;525(4):1087-1094. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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