2. Membrane Transporter/Ion Channel Neuronal Signaling Immunology/Inflammation PI3K/Akt/mTOR
  3. nAChR Interleukin Related Akt
  4. Lemairamin

Lemairamin (Wgx-50) is a hydroxylamine compound. Lemairamin can be isolated from the pericarps of the Zanthoxylum plants. Lemairamin activates α7nAChR, stimulates the expression of IL-10 and POMC. Lemairamin shows a decrease in Akt. Lemairamin attenuates DSS-induced intestinal inflammation. Lemairamin alleviates pain hypersensitivity.

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Lemairamin

Lemairamin Chemical Structure

CAS No. : 29946-61-0

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Lemairamin Related Antibodies

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Description

Lemairamin (Wgx-50) is a hydroxylamine compound. Lemairamin can be isolated from the pericarps of the Zanthoxylum plants. Lemairamin activates α7nAChR, stimulates the expression of IL-10 and POMC. Lemairamin shows a decrease in Akt. Lemairamin attenuates DSS-induced intestinal inflammation. Lemairamin alleviates pain hypersensitivity[1][2].

IC50 & Target[2][1]

IL-10

 

IL-6

 

IL-1β

 

In Vitro

Lemairamin (10 μM; 2 h) stimulates the expression of IL-10 and POMC in primary rat spinal cord microglia[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lemairamin Related Antibodies
In Vivo

Lemairamin (10 μL/L; immersion; 6-18 h) exerts dose-time-dependent anti-inflammatory effects in a zebrafish DSS-induced inflammatory bowel disease model, reducing neutrophil recruitment and pro-inflammatory cytokine expression, preserving intestinal morphology, and inhibiting Akt pathway activation, with maximal effects observed at 12 hours of treatment[1].
Lemairamin (1-300 mg/kg; s.c.) dose-dependently inhibits formalin-induced tonic pain in male Swiss mice with an Emax of 66.7% inhibition and an ED50 of 11.1 mg/kg, via activation of α7nAChRs[2].
Lemairamin (1-300 mg/kg; s.c.; single administration) dose-dependently inhibits formalin-induced tonic pain in adult Wistar rats with an Emax of 45.9% inhibition and an ED50 of 21.9 mg/kg[2].
Lemairamin (10-300 μg; i.t.; single administration) dose-dependently reduces mechanical allodynia in L5/L6 spinal nerve ligated Wistar rats with an Emax of 60.4% MPE and an ED50 of 83.9 μg, via α7nAChR activation and subsequent stimulation of spinal IL-10 and β-endorphin expression[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: wild-type (WT); Tg(lyz:EGFP) (transgenic for neutrophil labeling; 3-day-post-fertilization; DSS-induced intestinal inflammation)[1]
Dosage: 10 μL/L
Administration: 6, 12, or 18 hours
Result: Suppressed recruitment of neutrophils to the intestinal injury site, with the most significant reduction observed at 12 hours.
Significantly reduced the relative mRNA expression levels of pro-inflammatory cytokines il-1β, il-6, cxcl8a, and tnf-α, with the most significant reduction at 12 hours.
Preserved intestinal morphology, including intact, well-arranged intestinal epithelial cell structure, normal glandular structure, reduced intestinal vacuoles, alleviated DSS-induced increases in crypt depth, and restored the villus length to crypt depth ratio.
Significantly decreased the relative protein expression of p-Akt/Akt compared to the DSS-only group.
Significantly downregulated the relative mRNA expression levels of akt1, akt2, and akt3, which were upregulated by DSS treatment.
Molecular Weight

311.37

Formula

C19H21NO3
CAS No.
SMILES

O=C(/C=C/C1=CC=CC=C1)NCCC2=CC(OC)=C(C=C2)OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lemairamin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lemairamin29946-61-0Wgx-50Wgx50Wgx 50nAChRInterleukin RelatedAktNicotinic acetylcholine receptorsILPKBProtein kinase BAlzheimer's diseaseneutrophilinflammatory bowel diseasezebrafishprimary spinal microglial cellα7 nicotinic acetylcholine receptorAkt pathwaypro-inflammatory cytokineβ-endorphinIL-10Inhibitorinhibitorinhibit

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