steric hindrance

By Targets:	ABA Receptor (1) ADC Linker (3) Bacterial (1) Biochemical Assay Reagents (3) CD74 (1) Cyclophilin (1) DNA Alkylator/Crosslinker (1) Drug Intermediate (1) ERK (1) Exosomes (1) Fluorescent Dye (3) Glycosidase (1) Phosphatase (1) Ras (2) Transthyretin (TTR) (1)
By Research Areas:	Cancer (5) Infection (1)
Click Chemistry:	DBCO (2)
Oligonucleotides:	Polymers (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112624B

Dextran T70 (MW 70,000) Dextran 70; Dextran D70; Dextran T70(MW 64000-76000)	Bacterial	Others
Dextran 70,000 is a high molecular weight polysaccharide formed by glucose linked by α-(1→6) glycosidic bonds. Dextran 70,000 can expand blood volume through colloidal osmotic pressure effect and inhibit cell adhesion and platelet aggregation through steric hindrance. At the same time, Dextran 70,000 can be used as a drug carrier to achieve targeted delivery through endocytosis. Dextran 70,000 is biologically inert and has low immunogenicity. It can be used for clinical blood volume expansion, anti-thrombotic research, and evaluation of vascular permeability in in vitro experiments. It can also be combined with fluorescent dyes for cell tracking and drug delivery research. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance.

HY-151835

DBCO-PEG24-NHS ester	ADC Linker	Others
DBCO-PEG24-NHS ester is a click chemistry reagent. DBCO-PEG24-NHS ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only .

HY-155882

mPEG750-amine mPEG750-NH2	Biochemical Assay Reagents	Cancer
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .

HY-130086

Bis-PEG4-NHS ester	ADC Linker	Cancer
Bis-PEG4-NHS ester is a crosslinking reagent and amine-reactive modulator .Bis-PEG4-NHS ester reacts with primary amine groups on liposome surfaces via amide bond formation to covalently attach dibenzylcyclooctyne groups, with a hydrophilic PEG4 spacer reducing steric hindrance for subsequent click chemistry .Bis-PEG4-NHS ester enables site-specific antibody coupling to liposome surfaces via copper-free strain-promoted alkyne-azide cycloaddition click chemistry without disrupting liposome structure in minimal organic solvent volumes .Bis-PEG4-NHS ester undergoes hydrolysis during annealing to form -COOH groups that interact with PbI and FAI to enhance perovskite structural integrity, passivate defects, and modulate nucleation kinetics to regulate crystal growth .Bis-PEG4-NHS ester enhances device efficiency and long-term stability when used as an antisolvent additive for p-i-n perovskite solar cells .

HY-151827

DBCO-PEG2-NHS ester	ADC Linker	Others
DBCO-PEG2-NHS ester is a click chemistry reagent containing an azide group. DBCO-PEG2-NHS ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only .

HY-W591476

m-PEG1000-thiol mPEG1000-SH	Biochemical Assay Reagents	Others
m-PEG1000-thiol is a surface modifier that can modify DNA thiolation and is used in the synthesis of gold nanorods (AuNR). m-PEG1000-thiol can load thiolated DNA onto AuNR, form a covalent bond with the surface of gold nanoparticles through the thiol group, and stabilize the nanoparticles by the steric hindrance effect of the polyethylene glycol chain, preventing aggregation and enhancing its biocompatibility. m-PEG1000-thiol can also provide a platform for the subsequent coupling of biomolecules (such as DNA, antibodies) by replacing surfactants (such as CTAB) on the surface of nanoparticles, thereby exerting its activity in promoting the functionalization of nanomaterials [2].

HY-D1635

Sulfo-NHS-LC-LC-Biotin Biotin-XX-SSE	Fluorescent Dye Exosomes	Infection
Sulfo-NHS-LC-LC-Biotin (Biotin-XX-SSE), a biotin reagent, is used to label the proteins exposed to the external leaflet of intact exosomes and contains a larger spacer arm between the biotin and amine reactive linker. The size of this linker helps to overcome steric hindrance and increases labeling efficiency at the crowded exosome surface .

HY-W998680

Fluorescein-maleimide 5-FITC-Maleimide	Fluorescent Dye	Others
Fluorescein-maleimide (5-FITC-Maleimide) is a thiol-reactive fluorescent derivatization reagent and non-specific protein labeling reagent. Fluorescein-maleimide covalently binds to protein thiol groups for protein labeling. Fluorescein-maleimide covalently binds to protein amino and imidazole groups under neutral pH conditions. Fluorescein-maleimide is used for fluorescent labeling of proteins, nucleic acids or other molecules containing one or more thiol groups (Ex/Em = 494/519 nm) .

HY-120161

AS6 3'-Hexylsulfanylabscisic acid	ABA Receptor Phosphatase	Others
AS6 (3'-Hexylsulfanylabscisic acid) is a PYL antagonist with a K_d value of 0.48 μM for Arabidopsis PYL5. AS6 binds to PYL proteins, and its S-hexyl chain blocks PP2C binding via steric hindrance. AS6 alleviates the inhibitory effect of ABA on seed germination in Arabidopsis and lettuce .

HY-P2929B

PNGase F (Immobilized, Microspin)	Glycosidase	Others
PNGase F (Immobilized, Microspin) is a resin in which PNGase F (peptide N-glycosidase F) is covalently coupled to agarose beads, and it is used to remove N-glycans from antibodies, fusion proteins and other N-glycosylated proteins. The enzyme is recombinantly expressed in Escherichia coli, with its sequence derived from Flavobacterium meningsepticum .

HY-177894

Fmoc-Asp(OMpe)-Cbz	Drug Intermediate	Others
Fmoc-Asp(OMpe)-Cbz is a drug intermediate that can be used for the synthesis of Fmoc-Asp(OMpe)-OH.

HY-W131404

Boc-Aeg-OEt	Biochemical Assay Reagents	Others
Boc-Aeg-OEt is an aminoethylglycine monomer based on a Boc- and ethyl ester-protected AEG backbone, with substitution by a pyridine ligand. Boc-Aeg-OEt reduces steric hindrance in a series of dipeptide synthesis reactions, and has higher solubility in common solvents than the Fmoc-aeg-OtBu backbone .

HY-D3334

PE-CF594	Fluorescent Dye CD74	Others
PE-CF594 is a labeled monoclonal antibody conjugate that specifically binds to HLA-DR on the surface of monocytes and B cells, while acting as a signal attenuator. Through steric hindrance and a possible fluorescence resonance energy transfer mechanism, PE-CF594 specifically reduces the fluorescence intensity of PE-CD124 staining, but does not interfere with the staining of other PE-labeled antibodies such as CD40, CD4 or CD14. PE-CF594 can also be used to detect the emission signal of mt-Keima after excitation with a 561-nm laser, thereby effectively evaluating mitophagy activity .

HY-186087

RM-046	Ras ERK Cyclophilin	Cancer
RM-046 is an orally active, selective ternary complex inhibitor of KRAS ^Q61H (active form). RM-046 forms a ternary complex with cyclophilin A, binds to active KRAS ^Q61H in a non-covalent manner, blocks effector binding via steric hindrance and inhibits downstream signal transduction. RM-046 inhibits ERK phosphorylation and cancer cell proliferation, and induces sustained RAS pathway signal inhibition, anti-tumor activity and tumor regression in preclinical xenograft models. RM-046 can be used for the research of KRAS ^Q61H mutant cancers .

HY-186086

RM-041	Ras	Cancer
RM-041 is a selective, orally active KRAS ^G13C (ON) inhibitor that forms a covalent complex with KRAS ^G13C (ON) and Cyclophilin A. RM-041 blocks the binding of RAS effector proteins via steric hindrance, and then covalently binds to Cys-13 to form an irreversible inhibitory complex, thereby inhibiting the proliferation of KRAS ^G13C mutant cancer cells. RM-041 induces regression of KRAS ^G13C tumors in cellular and xenograft tumor models. RM-041 exerts a synergistic effect when combined with upstream node inhibitors (such as SHP2 inhibitors). RM-041 can be used for the research of non-small cell lung cancer .

HY-P11698

Guanidino-G-Clamp-PNA	DNA Alkylator/Crosslinker Transthyretin (TTR)	Cancer
Guanidino-G-Clamp-PNA is a highly efficient sequence-specific RNA binder and gene silencer. Guanidino-G-Clamp-PNA precisely targets such targets as miR-155 or transthyretin (TTR) mRNA through base pairing: the former regulates tumor-related signaling pathways by reducing microRNA activity, while the latter inhibits the translation of harmful proteins via steric hindrance. Guanidino-G-Clamp-PNA effectively stabilizes DNA/RNA duplexes, induces cancer cell apoptosis, and suppresses tumor growth. In addition, Guanidino-G-Clamp-PNA can be conjugated with targeting ligands to improve tissue-specific delivery and reduce in vivo adverse reactions, and it can also enhance the splicing regulation efficacy of other oligonucleotide platforms (such as PMO) when integrated into them. Guanidino-G-Clamp-PNA is applicable to the research of various diseases including diffuse large B-cell lymphoma and hereditary transthyretin-related amyloidosis .

Cat. No.	Product Name

HY-L913

Tyrosine Focused Covalent Fragment Library	104 compounds
Recently, significant advancements in tyrosine-targeting electrophiles have primarily occurred in the field of protein-protein interactions (PPIs), where cysteine residues are often underrepresented and novel chemistries are needed to address these interfaces. In this context, tyrosines are frequently more accessible compared to more buried binding sites. Moreover, they are commonly found at "hot spots," which are functional epitopes of PPIs, with 12.3% of the residues consisting of tyrosines. This prevalence is likely due to the hydrophobic nature of tyrosine, its ability to participate in aromatic π-interactions, and its capacity for hydrogen bonding. Beyond PPIs, some progress has also been made in covalent tyrosine targeting in other areas where more commonly addressed side chains are lacking. Even though tyrosine has a slightly lower pKa value compared to the protonated lysine side chain (approximately 10 vs. 10.5 for the unprotected amino acid side chains), significantly less progress has been made in the development of tyrosine-targeted covalent ligands compared to lysine. This is likely due to the reduced flexibility of the tyrosine side chain and the greater steric hindrance of its hydroxy group, which makes it more challenging to adopt suitable reaction geometries. Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 124 fragment molecules which can target tyrosine residue and can be used for fragment-based covalent drug discovery.

Tyrosine Focused Covalent Fragment Library

104 compounds

Recently, significant advancements in tyrosine-targeting electrophiles have primarily occurred in the field of protein-protein interactions (PPIs), where cysteine residues are often underrepresented and novel chemistries are needed to address these interfaces. In this context, tyrosines are frequently more accessible compared to more buried binding sites. Moreover, they are commonly found at "hot spots," which are functional epitopes of PPIs, with 12.3% of the residues consisting of tyrosines. This prevalence is likely due to the hydrophobic nature of tyrosine, its ability to participate in aromatic π-interactions, and its capacity for hydrogen bonding. Beyond PPIs, some progress has also been made in covalent tyrosine targeting in other areas where more commonly addressed side chains are lacking. Even though tyrosine has a slightly lower pKa value compared to the protonated lysine side chain (approximately 10 vs. 10.5 for the unprotected amino acid side chains), significantly less progress has been made in the development of tyrosine-targeted covalent ligands compared to lysine. This is likely due to the reduced flexibility of the tyrosine side chain and the greater steric hindrance of its hydroxy group, which makes it more challenging to adopt suitable reaction geometries.

Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 124 fragment molecules which can target tyrosine residue and can be used for fragment-based covalent drug discovery.

Cat. No.	Product Name	Type

HY-W998680

Fluorescein-maleimide 5-FITC-Maleimide	Fluorescent Dyes
Fluorescein-maleimide (5-FITC-Maleimide) is a thiol-reactive fluorescent derivatization reagent and non-specific protein labeling reagent. Fluorescein-maleimide covalently binds to protein thiol groups for protein labeling. Fluorescein-maleimide covalently binds to protein amino and imidazole groups under neutral pH conditions. Fluorescein-maleimide is used for fluorescent labeling of proteins, nucleic acids or other molecules containing one or more thiol groups (Ex/Em = 494/519 nm) .

Fluorescein-maleimide

5-FITC-Maleimide

Fluorescent Dyes

Fluorescein-maleimide (5-FITC-Maleimide) is a thiol-reactive fluorescent derivatization reagent and non-specific protein labeling reagent. Fluorescein-maleimide covalently binds to protein thiol groups for protein labeling. Fluorescein-maleimide covalently binds to protein amino and imidazole groups under neutral pH conditions. Fluorescein-maleimide is used for fluorescent labeling of proteins, nucleic acids or other molecules containing one or more thiol groups (Ex/Em = 494/519 nm) .

HY-D3334

PE-CF594	Fluorescent Dyes
PE-CF594 is a labeled monoclonal antibody conjugate that specifically binds to HLA-DR on the surface of monocytes and B cells, while acting as a signal attenuator. Through steric hindrance and a possible fluorescence resonance energy transfer mechanism, PE-CF594 specifically reduces the fluorescence intensity of PE-CD124 staining, but does not interfere with the staining of other PE-labeled antibodies such as CD40, CD4 or CD14. PE-CF594 can also be used to detect the emission signal of mt-Keima after excitation with a 561-nm laser, thereby effectively evaluating mitophagy activity .

PE-CF594

Fluorescent Dyes

PE-CF594 is a labeled monoclonal antibody conjugate that specifically binds to HLA-DR on the surface of monocytes and B cells, while acting as a signal attenuator. Through steric hindrance and a possible fluorescence resonance energy transfer mechanism, PE-CF594 specifically reduces the fluorescence intensity of PE-CD124 staining, but does not interfere with the staining of other PE-labeled antibodies such as CD40, CD4 or CD14. PE-CF594 can also be used to detect the emission signal of mt-Keima after excitation with a 561-nm laser, thereby effectively evaluating mitophagy activity .

Cat. No.	Product Name	Type

HY-112624B

Dextran T70 (MW 70,000) Dextran 70; Dextran D70; Dextran T70(MW 64000-76000)	Biochemical Assay Reagents
Dextran 70,000 is a high molecular weight polysaccharide formed by glucose linked by α-(1→6) glycosidic bonds. Dextran 70,000 can expand blood volume through colloidal osmotic pressure effect and inhibit cell adhesion and platelet aggregation through steric hindrance. At the same time, Dextran 70,000 can be used as a drug carrier to achieve targeted delivery through endocytosis. Dextran 70,000 is biologically inert and has low immunogenicity. It can be used for clinical blood volume expansion, anti-thrombotic research, and evaluation of vascular permeability in in vitro experiments. It can also be combined with fluorescent dyes for cell tracking and drug delivery research. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance.

Dextran T70 (MW 70,000)

Dextran 70; Dextran D70; Dextran T70(MW 64000-76000)

Biochemical Assay Reagents

Dextran 70,000 is a high molecular weight polysaccharide formed by glucose linked by α-(1→6) glycosidic bonds. Dextran 70,000 can expand blood volume through colloidal osmotic pressure effect and inhibit cell adhesion and platelet aggregation through steric hindrance. At the same time, Dextran 70,000 can be used as a drug carrier to achieve targeted delivery through endocytosis. Dextran 70,000 is biologically inert and has low immunogenicity. It can be used for clinical blood volume expansion, anti-thrombotic research, and evaluation of vascular permeability in in vitro experiments. It can also be combined with fluorescent dyes for cell tracking and drug delivery research. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance.

HY-155882

mPEG750-amine mPEG750-NH2	Biochemical Assay Reagents
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .

mPEG750-amine

mPEG750-NH2

Biochemical Assay Reagents

mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .

HY-W591476

m-PEG1000-thiol mPEG1000-SH	Biochemical Assay Reagents
m-PEG1000-thiol is a surface modifier that can modify DNA thiolation and is used in the synthesis of gold nanorods (AuNR). m-PEG1000-thiol can load thiolated DNA onto AuNR, form a covalent bond with the surface of gold nanoparticles through the thiol group, and stabilize the nanoparticles by the steric hindrance effect of the polyethylene glycol chain, preventing aggregation and enhancing its biocompatibility. m-PEG1000-thiol can also provide a platform for the subsequent coupling of biomolecules (such as DNA, antibodies) by replacing surfactants (such as CTAB) on the surface of nanoparticles, thereby exerting its activity in promoting the functionalization of nanomaterials [2].

m-PEG1000-thiol

mPEG1000-SH

Biochemical Assay Reagents

m-PEG1000-thiol is a surface modifier that can modify DNA thiolation and is used in the synthesis of gold nanorods (AuNR). m-PEG1000-thiol can load thiolated DNA onto AuNR, form a covalent bond with the surface of gold nanoparticles through the thiol group, and stabilize the nanoparticles by the steric hindrance effect of the polyethylene glycol chain, preventing aggregation and enhancing its biocompatibility. m-PEG1000-thiol can also provide a platform for the subsequent coupling of biomolecules (such as DNA, antibodies) by replacing surfactants (such as CTAB) on the surface of nanoparticles, thereby exerting its activity in promoting the functionalization of nanomaterials [2].

Cat. No.	Product Name	Target	Research Area

HY-W131404

Boc-Aeg-OEt	Biochemical Assay Reagents	Others
Boc-Aeg-OEt is an aminoethylglycine monomer based on a Boc- and ethyl ester-protected AEG backbone, with substitution by a pyridine ligand. Boc-Aeg-OEt reduces steric hindrance in a series of dipeptide synthesis reactions, and has higher solubility in common solvents than the Fmoc-aeg-OtBu backbone .

HY-P11698

Guanidino-G-Clamp-PNA	DNA Alkylator/Crosslinker Transthyretin (TTR)	Cancer
Guanidino-G-Clamp-PNA is a highly efficient sequence-specific RNA binder and gene silencer. Guanidino-G-Clamp-PNA precisely targets such targets as miR-155 or transthyretin (TTR) mRNA through base pairing: the former regulates tumor-related signaling pathways by reducing microRNA activity, while the latter inhibits the translation of harmful proteins via steric hindrance. Guanidino-G-Clamp-PNA effectively stabilizes DNA/RNA duplexes, induces cancer cell apoptosis, and suppresses tumor growth. In addition, Guanidino-G-Clamp-PNA can be conjugated with targeting ligands to improve tissue-specific delivery and reduce in vivo adverse reactions, and it can also enhance the splicing regulation efficacy of other oligonucleotide platforms (such as PMO) when integrated into them. Guanidino-G-Clamp-PNA is applicable to the research of various diseases including diffuse large B-cell lymphoma and hereditary transthyretin-related amyloidosis .

Cat. No.	Product Name		Classification

HY-151835

DBCO-PEG24-NHS ester		DBCO
DBCO-PEG24-NHS ester is a click chemistry reagent. DBCO-PEG24-NHS ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only .

HY-151827

DBCO-PEG2-NHS ester		DBCO
DBCO-PEG2-NHS ester is a click chemistry reagent containing an azide group. DBCO-PEG2-NHS ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only .

Cat. No.	Product Name		Classification

HY-112624B

Dextran T70 (MW 70,000) Dextran 70; Dextran D70; Dextran T70(MW 64000-76000)		Polymers
Dextran 70,000 is a high molecular weight polysaccharide formed by glucose linked by α-(1→6) glycosidic bonds. Dextran 70,000 can expand blood volume through colloidal osmotic pressure effect and inhibit cell adhesion and platelet aggregation through steric hindrance. At the same time, Dextran 70,000 can be used as a drug carrier to achieve targeted delivery through endocytosis. Dextran 70,000 is biologically inert and has low immunogenicity. It can be used for clinical blood volume expansion, anti-thrombotic research, and evaluation of vascular permeability in in vitro experiments. It can also be combined with fluorescent dyes for cell tracking and drug delivery research. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance.

HY-155882

mPEG750-amine mPEG750-NH2		Polymers
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .

HY-W591476

m-PEG1000-thiol mPEG1000-SH		Polymers
m-PEG1000-thiol is a surface modifier that can modify DNA thiolation and is used in the synthesis of gold nanorods (AuNR). m-PEG1000-thiol can load thiolated DNA onto AuNR, form a covalent bond with the surface of gold nanoparticles through the thiol group, and stabilize the nanoparticles by the steric hindrance effect of the polyethylene glycol chain, preventing aggregation and enhancing its biocompatibility. m-PEG1000-thiol can also provide a platform for the subsequent coupling of biomolecules (such as DNA, antibodies) by replacing surfactants (such as CTAB) on the surface of nanoparticles, thereby exerting its activity in promoting the functionalization of nanomaterials [2].

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Remarks

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Click Chemistry

Oligonucleotides