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Results for "

sulfonamide derivative

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (1) Antibiotic (1) Apoptosis (1) Bacterial (4) Biochemical Assay Reagents (1) Carbonic Anhydrase (4) Ceramidase (1) Cholinesterase (ChE) (1) COX (3) Drug Intermediate (2) EGFR (1) Endogenous Metabolite (2) Environmental Pollutants (1) Ferroptosis (1) Integrin (2) Isotope-Labeled Compounds (3) LIM Kinase (LIMK) (1) Microtubule/Tubulin (1) MMP (1) Molecular Glues (1) NF-κB (1) ROR (1) Sodium Channel (1) Wnt (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Infection (6) Inflammation/Immunology (6) Metabolic Disease (5) Neurological Disease (5)

By Targets:

Drug Derivative (1)

Antibiotic (1)

Apoptosis (1)

Bacterial (4)

Biochemical Assay Reagents (1)

Carbonic Anhydrase (4)

Ceramidase (1)

Cholinesterase (ChE) (1)

COX (3)

Drug Intermediate (2)

EGFR (1)

Endogenous Metabolite (2)

Environmental Pollutants (1)

Ferroptosis (1)

Integrin (2)

Isotope-Labeled Compounds (3)

LIM Kinase (LIMK) (1)

Microtubule/Tubulin (1)

MMP (1)

Molecular Glues (1)

NF-κB (1)

ROR (1)

Sodium Channel (1)

Wnt (1)

By Research Areas:

Cancer (6)

Cardiovascular Disease (1)

Infection (6)

Inflammation/Immunology (6)

Metabolic Disease (5)

Neurological Disease (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Isotope-Labeled Compounds

Targets Recommended: Drug Derivative

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14571

E7820 5 Publications Verification ER68203-00	Molecular Glues Integrin	Infection Metabolic Disease Cancer
E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a molecular glue that induces the targeted degradation of splicing factor RBM39 by recruiting the E3 ubiquitin ligase CUL4-RBX1-DDB1-DCAF15 (CRL4 ^DCAF15). E7820 is an angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC₅₀ of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. E7820 can be used for the study of acute myeloid leukemia (AML) .

HY-B1386

Halazone	Environmental Pollutants Bacterial Sodium Channel Carbonic Anhydrase	Infection
Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a K_d value of 1.45 μM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water .

HY-69077

5-Bromo-1H-pyrazolo[3,4-b]pyridine	Drug Intermediate	Infection
5-Bromo-1H-pyrazolo[3,4-b]pyridine is a drug intermediate that can be used for the synthesis of sulfonamide derivatives.

HY-155765

Anti-inflammatory agent 51	NF-κB	Inflammation/Immunology
Anti-inflammatory agent 51 (compound 11d) is an amide/sulfonamide derivative with anti-inflammatory activities. Anti-inflammatory agent 51 inhibits NF-κB activation, has the potential for acute lung injury and ulcerative colitis research .

HY-W004121

4-Biphenylsulfonyl chloride	Drug Intermediate	Cancer
4-Biphenylsulfonyl chloride is a synthetic intermediate that participates in the sulfonamide formation reaction to synthesize antiproliferative compounds. The derivatives of 4-Biphenylsulfonyl chloride inhibit human head and neck squamous cell carcinoma (HNSCC) cells by increasing PTEN expression and inhibiting the PI3K/Akt/mTOR pathway. 4-Biphenylsulfonyl chloride can be used in the development of anticancer drugs for HNSCC .

HY-177331

BTT-3034	Integrin	Cardiovascular Disease
BTT-3034, a sulfonamide derivative, is an α2β1 integrin inhibitor. BTT-3034 inhibits cell adhesion to rat tail collagen I with an EC₅₀ of 160 nM and a corresponding E_maxof 86%. BTT-3034 inhibits collagen binding by an α2 variant carrying the conformationally activating E318W mutation .

HY-148431

Antimicrobial agent-14	Bacterial	Infection
Antimicrobial agent-14, a benzyl thiophene sulfonamide derivative is an antimicrobial agent, with a MIC of 200 μM against Campylobacter coli ATCC33559. Antimicrobial agent-14 can be used for the research of bacterial foodborne gastroenteritis .

HY-135843

TH-263	LIM Kinase (LIMK)	Cancer
TH-263, a diaryl sulfonamide derivative, is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257 .

HY-B0553S

Methazolamide-d6 L584601-d₆	Isotope-Labeled Compounds Carbonic Anhydrase	Inflammation/Immunology
Methazolamide-d₆ is the deuterium labeled Methazolamide. Methazolamide (L584601) is a sulfonamide derivative used as a carbonic anhydrase inhibitor with a K_i of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders .

HY-147388

hiCE inhibitor-1	Cholinesterase (ChE)	Metabolic Disease
hiCE inhibitor-1, a sulfonamide derivative, is a selective human intestinal enzyme (hiCE) inhibitor with a K_i value of 53.3 nM. hiCE inhibitor-1 can be used to improve Irinotecan (HY-16562)-induced diarrhoea .

HY-177324

Antibacterial agent 290	Bacterial	Infection Neurological Disease Cancer
Antibacterial agent 290 (Compound YY), a sulfonamide derivative, is an antibacterial agent. Antibacterial agent 290 has antiproliferative activity against a variety of tumor cells. Antibacterial agent 290 significantly activates the E3 Ligase Parkin auto-ubiquitinvlation with an EC₅₀ of 0.4 μM. Antibacterial agent 290 can used for synthesis of building blocks for various supramolecular structures such as metal-organic skeletons and coordination polymers. Antibacterial agent 290 can be used for cancers, neurology disorders and infections research .

HY-CE01569

Phenylalanine-N-sulfonamide-CoA Phenylalanine-N-sulfonamide-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
Phenylalanine-N-sulfonamide-CoA (Phenylalanine-N-sulfonamide-coenzyme A) is a coenzyme A derivative .

HY-W031230

N4-Acetylsulfamerazine Acetylsulfamerazine; Sulfamelazine	Endogenous Metabolite	Metabolic Disease
N4-Acetylsulfamerazine is a sulfonamides derivative .

HY-123438

WAY-151693	MMP	Others
WAY-151693, sulfonamide derivative of a hydroxamic acid, acts as a potent inhibitor of MMP13 in virtual screening .

HY-B0512S1

Sulfamerazine-13C6 RP2632-¹³C₆	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Sulfamerazine- ¹³C₆ (RP2632- ¹³C₆) is ¹³C labeled Sulfamerazine (HY-B0512). Sulfamerazine (RP-2632) is a sulfonamide antibacterial. Sulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthesizes.

HY-168179

RORγt inverse agonist 32	ROR	Inflammation/Immunology
RORγt inverse agonist 32 (compound b14) is orally active. RORγt inverse agonist 32 can be used in inflammation research .

HY-W698694

N4-Acetylsulfamerazine-d4 Acetylsulfamerazine-d₄; Sulfamelazine-d₄	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
N4-Acetylsulfamerazine-d₄ (Acetylsulfamerazine-d₄; Sulfamelazine-d₄) is the deuterium labeled N4-Acetylsulfamerazine (HY-W031230). N4-Acetylsulfamerazine is a sulfonamides derivative .

HY-163718

Ferroptosis-IN-9	Ferroptosis	Neurological Disease
Ferroptosis-IN-9 (compound 23b) is a ferroptosis inhibitor with an IC₅₀ value of >30uM for hERG inhibition. Ferroptosis-IN-9 is a ROS scavenger. Ferroptosis-IN-9 can be used in neurodegenerative disease research .

HY-157223

ARN16186	Ceramidase	Inflammation/Immunology
ARN16186;ARN 16186;ARN-16186

HY-163116

Anti-inflammatory agent 67	COX Carbonic Anhydrase	Neurological Disease Inflammation/Immunology
Anti-inflammatory agent 67 (compound 7a) is a dual inhibitor of carbonic anhydrase and COX-2, a sulfonamide derivative of Polmacoxib (HY-16726), and has anti-inflammatory properties and analgesic activity. Anti-inflammatory agent 67 has IC₅₀s of 10.4 μM and 50 nM for COX-1 and COX-2, respectively. The Ki of anti-inflammatory agent 67 binding to different isoforms of carbonic anhydrase are 48.3 nM (CA I), 42.2 nM (CA II), 52.3 nM (CA IX), and 13.3 nM (CA XII) .

HY-163117

Anti-inflammatory agent 68	COX Carbonic Anhydrase	Neurological Disease Inflammation/Immunology
Anti-inflammatory agent 68 (compound 7b) is a dual inhibitor of carbonic anhydrase and COX-2, a sulfonamide derivative of Polmacoxib (HY-16726), with anti-inflammatory properties and analgesic activity. Anti-inflammatory agent 68 has IC₅₀s of 12.6 μM and 60 nM for COX-1 and COX-2, respectively. The Ki of anti-inflammatory agent 68 binding to different isoforms of carbonic anhydrase are 52.6 nM (CA I), 79.1 nM (CA II), 58.1 nM (CA IX), and 17.2 nM (CA XII) .

HY-121155

AD11	Drug Derivative	Neurological Disease
AD11, a sulfonamide derivative, exhibits anticonvulsant potency in the rat .

HY-180449

AXIN2/β-catenin-IN-1	Microtubule/Tubulin Wnt	Cancer
Anticancer agent 291 (Compound 2406) is an anti-cancer agent. Anticancer agent 291 interferes with the integrity of the β-tubulin cytoskeleton and inhibits the Wnt/β-catenin signal transduction. Anticancer agent 291 significantly inhibits the invasion, migration and colony formation of tumor cells. Anticancer agent 291 induces the cell cycle of EC-9706 and HT-29 cells to arrest at the G2/M phase and inhibits cell proliferation. Anticancer agent 291 can be used for the study of gastrointestinal cancer .

HY-180541

EGFR-IN-190	COX EGFR Apoptosis	Cancer
EGFR-IN-190 (Compound 3o) is an inhibitor that targets both EGFR (IC₅₀ = 0.028 μM) and COX-2 (IC₅₀ = 0.208 μM). EGFR-IN-190 exhibits potent inhibitory activity against MCF-7 cells and induces apoptosis (apoptosis). EGFR-IN-190 can be used for research on breast cancer .

Cat. No.	Product Name	Type

HY-69077

5-Bromo-1H-pyrazolo[3,4-b]pyridine	Biochemical Assay Reagents
5-Bromo-1H-pyrazolo[3,4-b]pyridine is a drug intermediate that can be used for the synthesis of sulfonamide derivatives.

HY-W004121

4-Biphenylsulfonyl chloride	Biochemical Assay Reagents
4-Biphenylsulfonyl chloride is a synthetic intermediate that participates in the sulfonamide formation reaction to synthesize antiproliferative compounds. The derivatives of 4-Biphenylsulfonyl chloride inhibit human head and neck squamous cell carcinoma (HNSCC) cells by increasing PTEN expression and inhibiting the PI3K/Akt/mTOR pathway. 4-Biphenylsulfonyl chloride can be used in the development of anticancer drugs for HNSCC .

4-Biphenylsulfonyl chloride

Biochemical Assay Reagents

4-Biphenylsulfonyl chloride is a synthetic intermediate that participates in the sulfonamide formation reaction to synthesize antiproliferative compounds. The derivatives of 4-Biphenylsulfonyl chloride inhibit human head and neck squamous cell carcinoma (HNSCC) cells by increasing PTEN expression and inhibiting the PI3K/Akt/mTOR pathway. 4-Biphenylsulfonyl chloride can be used in the development of anticancer drugs for HNSCC .

Cat. No.	Product Name	Chemical Structure

HY-B0553S

Methazolamide-d6
Methazolamide-d₆ is the deuterium labeled Methazolamide. Methazolamide (L584601) is a sulfonamide derivative used as a carbonic anhydrase inhibitor with a K_i of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders .

HY-B0512S1

Sulfamerazine-13C6
Sulfamerazine- ¹³C₆ (RP2632- ¹³C₆) is ¹³C labeled Sulfamerazine (HY-B0512). Sulfamerazine (RP-2632) is a sulfonamide antibacterial. Sulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthesizes.

Sulfamerazine-13C6

Sulfamerazine- ¹³C₆ (RP2632- ¹³C₆) is ¹³C labeled Sulfamerazine (HY-B0512). Sulfamerazine (RP-2632) is a sulfonamide antibacterial. Sulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthesizes.

HY-W698694

N4-Acetylsulfamerazine-d4
N4-Acetylsulfamerazine-d₄ (Acetylsulfamerazine-d₄; Sulfamelazine-d₄) is the deuterium labeled N4-Acetylsulfamerazine (HY-W031230). N4-Acetylsulfamerazine is a sulfonamides derivative .

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