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tyrosinase substrates

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By Targets:	Tyrosinase (10) Antibiotic (1) Bacterial (1) Dopamine Receptor (1) Environmental Pollutants (1) Phosphatase (1) PKA (2) Reactive Oxygen Species (ROS) (1) Reference Standards (2)
By Research Areas:	Cancer (2) Infection (3) Inflammation/Immunology (2) Metabolic Disease (5) Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dyes

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Products

Targets Recommended: Tyrosinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1750

3-(2,4-Dihydroxyphenyl)propanoic acid	Tyrosinase	Metabolic Disease
3-(2,4-Dihydroxyphenyl) propanoic acid (DPPacid) is a competitive *Tyrosinase* inhibitor. It exhibits an IC₅₀ value of 3.02 μM against mushroom tyrosinase with L-tyrosine as the substrate, an IC₅₀ value of 62 μM with DL-DOPA as the substrate, and a K_i value of 11.5 μM. 3-(2,4-Dihydroxyphenyl) propanoic acid shows no DPPH radical scavenging activity. It can be used in studies related to ultraviolet B (UVB)-induced hyperpigmentation .

HY-113404

DL-Dopa	Tyrosinase Dopamine Receptor	Neurological Disease
DL-Dopa is a dopamine precursor. It serves as a substrate for Mushroom Tyrosinase, which oxidizes it to dopaquinone, an intermediate in the DOPA-melanin polymerization process, and this reaction can be detected at 475 nm. DL-Dopa also forms synergistic hydrophobic and π-π stacking interactions with cationic surfactants. Its binding to cetylpyridinium chloride (HY-B1464) is stronger and exhibits better thermodynamic stability than its binding to benzalkonium chloride (HY-B2232). DL-Dopa can compensate for dopamine depletion in the brain and is applicable to research related to Parkinson's disease .

HY-W015782

4-Ethylresorcinol	Tyrosinase PKA	Metabolic Disease Inflammation/Immunology
4-Ethylresorcinol is a derivative of resorcinol and can serve as a substrate for *tyrosinase*. 4-Ethylresorcinol has anti-hyperpigmentation and antioxidant effects and can inhibit melanin synthesis. 4-Ethylresorcinol has potential whitening value .

HY-W037976

Tyrosinase-IN-22 5-Chloro-2-mercaptobenzimidazole	Reactive Oxygen Species (ROS) Tyrosinase	Cancer
Tyrosinase-IN-22 (compound 4) is an inhibitor of tyrosinase substrates (L-tyrosine and L-dopa) with IC₅₀s of 60 nM and 30 nM, respectively. Tyrosinase-IN-22 also shows potent antioxidant and anti-melanogenic properties, thus can be used for relevant researches .

HY-W015616

Benzylacetone 4-Penylbutan-2-one	Environmental Pollutants Tyrosinase	Infection Metabolic Disease
Benzylacetone (4-Penylbutan-2-one) is an aromatic compound. Benzylacetone is a mushroom *tyrosinase* inhibitor with an IC₅₀ of 2.8 mM, a K_i of 1.25 mM for monophenolase and an IC₅₀ of 0.6 mM, a K_i of 0.39 mM for diphenolase. Benzylacetone inhibits free mushroom tyrosinase and enzyme-substrate complex. Benzylacetone acts as an appetite enhancer via olfactory stimulation, reduces spontaneous locomotor activity, induces weight gain. Benzylacetone exhibits repellent, fumigant, and contact toxicity against Tribolium castaneum adults .

HY-136595

3,5-Difluoro-L-tyrosine	Phosphatase	Others
3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine can be used to analyze the substrate specificity of protein tyrosine phosphatases (PTPs) .

HY-116750

6-Hydroxykaempferol	Tyrosinase	Others
6-Hydroxykaempferol, a flavonoid, is a competitive *tyrosinase* inhibitor with an IC₅₀ value of 124 μM. 6-Hydroxykaempferol has a K_i value of 148 μM relative to L-DOPA as a substrate and effectively inhibits the activity of the enzyme by binding to the active site of the enzyme .

HY-162524

Tyrosinase-IN-28	Tyrosinase	Others
Tyrosinase-IN-28 (Compound 4l) is an inhibitor for tyrosinase with IC₅₀ of 72.55 μM, by affecting both substrate binding and enzyme catalysis .

HY-175795

Tyrosinase activator-1	Tyrosinase Bacterial Antibiotic	Infection
Tyrosinase activator-1 (Compound 7A) is a *Tyrosinase* activator. Tyrosinase activator-1 significant antibacterial activity against gram-positive bacteria, such as MRSA, Staphylococcus aureus ATCC653 and Enterococcus faecium with MICs of 12.5-20  μM. Tyrosinase activator-1 activates tyrosinase by competitively occupying the binding site of L-DOPA on the surface of tyrosinase without interfering with the substrate binding at the active center. Tyrosinase activator-1 can be used for bacterial infections and antibiotics development research .

HY-W015616R

Benzylacetone (Standard) 4-Penylbutan-2-one (Standard)	Tyrosinase Reference Standards	Infection Metabolic Disease
Benzylacetone (4-Penylbutan-2-one) (Standard) is the analytical standard of Benzylacetone (HY-W015616). This product is intended for research and analytical applications. Benzylacetone is an aromatic compound. Benzylacetone is a mushroom *tyrosinase* inhibitor with an IC₅₀ of 2.8 mM, a K_i of 1.25 mM for monophenolase and an IC₅₀ of 0.6 mM, a K_i of 0.39 mM for diphenolase. Benzylacetone inhibits free mushroom tyrosinase and enzyme-substrate complex. Benzylacetone acts as an appetite enhancer via olfactory stimulation, reduces spontaneous locomotor activity, induces weight gain. Benzylacetone exhibits repellent, fumigant, and contact toxicity against Tribolium castaneum adults .

HY-W015782R

4-Ethylresorcinol (Standard)	Tyrosinase PKA Reference Standards	Metabolic Disease Inflammation/Immunology
4-Ethylresorcinol (Standard) is the analytical standard of 4-Ethylresorcinol (HY-W015782). This product is intended for research and analytical applications. 4-Ethylresorcinol is a derivative of resorcinol and can serve as a substrate for tyrosinase. 4-Ethylresorcinol has anti-hyperpigmentation and antioxidant effects and can inhibit melanin synthesis. 4-Ethylresorcinol has potential whitening value .

HY-D3141

DR probe		Cancer
DR probe is a "dual-key-and-lock" fluorescent probe designed based on the Resorufin (HY-123533) scaffold (Ex/Em = 647 nm/663-738 nm). DR probe can be sequentially activated by hydrogen peroxide to form the intermediate SR, which acts as a tyrosinase substrate to trigger a fluorescence turn-on signal. DR probe can distinguish normal melanocytes from melanoma cells. DR probe supports cell imaging and can be applied to mouse melanoma models to achieve melanoma diagnosis with higher accuracy and lower false-positive rates. DR probe is applicable to relevant research on melanoma .

Cat. No.	Product Name	Type

HY-D3141

DR probe	Fluorescent Dyes
DR probe is a "dual-key-and-lock" fluorescent probe designed based on the Resorufin (HY-123533) scaffold (Ex/Em = 647 nm/663-738 nm). DR probe can be sequentially activated by hydrogen peroxide to form the intermediate SR, which acts as a tyrosinase substrate to trigger a fluorescence turn-on signal. DR probe can distinguish normal melanocytes from melanoma cells. DR probe supports cell imaging and can be applied to mouse melanoma models to achieve melanoma diagnosis with higher accuracy and lower false-positive rates. DR probe is applicable to relevant research on melanoma .

DR probe

Fluorescent Dyes

DR probe is a "dual-key-and-lock" fluorescent probe designed based on the Resorufin (HY-123533) scaffold (Ex/Em = 647 nm/663-738 nm). DR probe can be sequentially activated by hydrogen peroxide to form the intermediate SR, which acts as a tyrosinase substrate to trigger a fluorescence turn-on signal. DR probe can distinguish normal melanocytes from melanoma cells. DR probe supports cell imaging and can be applied to mouse melanoma models to achieve melanoma diagnosis with higher accuracy and lower false-positive rates. DR probe is applicable to relevant research on melanoma .

3-(2,4-Dihydroxyphenyl)propanoic acid	Structural Classification Natural Products Classification of Application Fields Plants Moraceae Endogenous metabolite Human Gut Microbiota Metabolites Ficus carica L. Other Diseases Phenols Polyphenols Disease Research Fields Source Classification	Tyrosinase
3-(2,4-Dihydroxyphenyl) propanoic acid (DPPacid) is a competitive *Tyrosinase* inhibitor. It exhibits an IC₅₀ value of 3.02 μM against mushroom tyrosinase with L-tyrosine as the substrate, an IC₅₀ value of 62 μM with DL-DOPA as the substrate, and a K_i value of 11.5 μM. 3-(2,4-Dihydroxyphenyl) propanoic acid shows no DPPH radical scavenging activity. It can be used in studies related to ultraviolet B (UVB)-induced hyperpigmentation .

DL-Dopa	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields Source Classification	Tyrosinase Dopamine Receptor
DL-Dopa is a dopamine precursor. It serves as a substrate for Mushroom Tyrosinase, which oxidizes it to dopaquinone, an intermediate in the DOPA-melanin polymerization process, and this reaction can be detected at 475 nm. DL-Dopa also forms synergistic hydrophobic and π-π stacking interactions with cationic surfactants. Its binding to cetylpyridinium chloride (HY-B1464) is stronger and exhibits better thermodynamic stability than its binding to benzalkonium chloride (HY-B2232). DL-Dopa can compensate for dopamine depletion in the brain and is applicable to research related to Parkinson's disease .

4-Ethylresorcinol	Classification of Application Fields Phenols Polyphenols Metabolic Disease Umbelliferae Plants Disease Research Fields Echinacea angustifolia DC. Source Classification	Tyrosinase PKA
4-Ethylresorcinol is a derivative of resorcinol and can serve as a substrate for *tyrosinase*. 4-Ethylresorcinol has anti-hyperpigmentation and antioxidant effects and can inhibit melanin synthesis. 4-Ethylresorcinol has potential whitening value .

Benzylacetone 4-Penylbutan-2-one	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Thymelaeaceae Metabolic Disease Plants Aquilaria sinensis (Lour.) Spreng. Disease Research Fields Source Classification	Environmental Pollutants Tyrosinase
Benzylacetone (4-Penylbutan-2-one) is an aromatic compound. Benzylacetone is a mushroom *tyrosinase* inhibitor with an IC₅₀ of 2.8 mM, a K_i of 1.25 mM for monophenolase and an IC₅₀ of 0.6 mM, a K_i of 0.39 mM for diphenolase. Benzylacetone inhibits free mushroom tyrosinase and enzyme-substrate complex. Benzylacetone acts as an appetite enhancer via olfactory stimulation, reduces spontaneous locomotor activity, induces weight gain. Benzylacetone exhibits repellent, fumigant, and contact toxicity against Tribolium castaneum adults .

6-Hydroxykaempferol	Flavonols Flavonoids Trifolium repens Linn. Leguminosae Plants Source Classification	Tyrosinase
6-Hydroxykaempferol, a flavonoid, is a competitive *tyrosinase* inhibitor with an IC₅₀ value of 124 μM. 6-Hydroxykaempferol has a K_i value of 148 μM relative to L-DOPA as a substrate and effectively inhibits the activity of the enzyme by binding to the active site of the enzyme .

Benzylacetone (Standard) 4-Penylbutan-2-one (Standard)	Structural Classification Ketones, Aldehydes, Acids Thymelaeaceae Plants Aquilaria sinensis (Lour.) Spreng. Source Classification	Tyrosinase Reference Standards
Benzylacetone (4-Penylbutan-2-one) (Standard) is the analytical standard of Benzylacetone (HY-W015616). This product is intended for research and analytical applications. Benzylacetone is an aromatic compound. Benzylacetone is a mushroom *tyrosinase* inhibitor with an IC₅₀ of 2.8 mM, a K_i of 1.25 mM for monophenolase and an IC₅₀ of 0.6 mM, a K_i of 0.39 mM for diphenolase. Benzylacetone inhibits free mushroom tyrosinase and enzyme-substrate complex. Benzylacetone acts as an appetite enhancer via olfactory stimulation, reduces spontaneous locomotor activity, induces weight gain. Benzylacetone exhibits repellent, fumigant, and contact toxicity against Tribolium castaneum adults .

4-Ethylresorcinol (Standard)	Structural Classification Phenols Polyphenols Umbelliferae Plants Echinacea angustifolia DC. Source Classification	Tyrosinase PKA Reference Standards
4-Ethylresorcinol (Standard) is the analytical standard of 4-Ethylresorcinol (HY-W015782). This product is intended for research and analytical applications. 4-Ethylresorcinol is a derivative of resorcinol and can serve as a substrate for tyrosinase. 4-Ethylresorcinol has anti-hyperpigmentation and antioxidant effects and can inhibit melanin synthesis. 4-Ethylresorcinol has potential whitening value .

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tyrosinase substrates

Inhibitors & Agonists

Fluorescent Dyes

NaturalProducts

Natural
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