3-(2,4-Dihydroxyphenyl)propanoic acid
Based on 1 Customer Validation
3-(2,4-Dihydroxyphenyl) propanoic acid (DPPacid) is a competitive Tyrosinase inhibitor. It exhibits an IC50 value of 3.02 μM against mushroom tyrosinase with L-tyrosine as the substrate, an IC50 value of 62 μM with DL-DOPA as the substrate, and a Ki value of 11.5 μM. 3-(2,4-Dihydroxyphenyl) propanoic acid shows no DPPH radical scavenging activity. It can be used in studies related to ultraviolet B (UVB)-induced hyperpigmentation.
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- Pureza: 99.39%
- No. CAS: 5631-68-5
- Fòrmula: C9H10O4
- Peso molecular:182.18
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Almacenamiento:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-N1750R
3-(2,4-Dihydroxyphenyl)propanoic acid (Standard)
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![Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2](https://file.medchemexpress.com/product_pic/hy-p3662.gif)
HY-P3662
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
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HY-101243
XMD16-5
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Tetrapeptide-30
Actividad biológica
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Human Endogenous Metabolite |
3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) inhibits mushroom tyrosinase with an IC50 of 3.02 μM using L-tyrosine as the substrate[1].
3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) acts as a competitive inhibitor of mushroom tyrosinase with an IC50 of 62 μM and Ki of 11.5 μM using DL-DOPA as the substrate[1].
3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) (50 μM; 20 min) exhibits no DPPH free radical scavenging activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 5631-68-5
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Appearance Solid
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Peso molecular 182.18
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Fòrmula C9H10O4
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Color Brown to orange
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SMILES
O=C(O)CCC1=CC=C(O)C=C1O
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Structure Classification
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvente y solubilidad
DMSO : 250 mg/mL (1372.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (11.42 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (11.42 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.4891 mL | 27.4454 mL | 54.8908 mL | 137.2269 mL |
| 5 mM | 1.0978 mL | 5.4891 mL | 10.9782 mL | 27.4454 mL | |
| 10 mM | 0.5489 mL | 2.7445 mL | 5.4891 mL | 13.7227 mL | |
| 15 mM | 0.3659 mL | 1.8297 mL | 3.6594 mL | 9.1485 mL | |
| 20 mM | 0.2745 mL | 1.3723 mL | 2.7445 mL | 6.8613 mL | |
| 25 mM | 0.2196 mL | 1.0978 mL | 2.1956 mL | 5.4891 mL | |
| 30 mM | 0.1830 mL | 0.9148 mL | 1.8297 mL | 4.5742 mL | |
| 40 mM | 0.1372 mL | 0.6861 mL | 1.3723 mL | 3.4307 mL | |
| 50 mM | 0.1098 mL | 0.5489 mL | 1.0978 mL | 2.7445 mL | |
| 60 mM | 0.0915 mL | 0.4574 mL | 0.9148 mL | 2.2871 mL | |
| 80 mM | 0.0686 mL | 0.3431 mL | 0.6861 mL | 1.7153 mL | |
| 100 mM | 0.0549 mL | 0.2745 mL | 0.5489 mL | 1.3723 mL |
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