1. Metabolic Enzyme/Protease
  2. Tyrosinase
  3. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 

Cat. No.: HY-P3662 Purity: 99.95%
COA Handling Instructions

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model.

For research use only. We do not sell to patients.

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Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 Chemical Structure

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 Chemical Structure

CAS No. : 82188-67-8

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Based on 1 publication(s) in Google Scholar

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Description

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model[1][2].

In Vitro

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 (0.1 pM-1 μM; 48 h) stimulates tyrosinase activity in a dose-dependent manner in Cloudman S91 mouse melanoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 (0-50 pM; i.c.v.; single dose) exerts thermoregulatory effect in rats model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat model[2]
Dosage: 0, 0.5, 1, 5, 10, or 50 pM peptide in 0.5 μL sterile saline
Administration: Intracerebroventricular injection in the anterior hypothalamic-preoptic area (AHPOA) of rats; single dose; recorded 0, 10, 20, 30, 40, 50, and 60 min after injection
Result: Showed greater difference than mean temperatures of animals receiving sterile saline group.
Molecular Weight

985.10

Formula

C47H64N14O10

CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

Ac-{Nle}-EH-{d-Phe}-RWG-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
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