Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
Based on 1 Customer Validation
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model.
For research use only. We do not sell to patients.
- Purity: 99.44%
- CAS No.: 82188-67-8
- Formula: C47H64N14O10
- Molecular Weight:985.10
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
![Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 Chemical Structure](https://file.medchemexpress.com/product_pic/hy-p3662.gif "Click to View Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 Chemical Structure")
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 (0.1 pM-1 μM; 48 h) stimulates tyrosinase activity in a dose-dependent manner in Cloudman S91 mouse melanoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat model[2]
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Dosage:0, 0.5, 1, 5, 10, or 50 pM peptide in 0.5 μL sterile saline
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Administration:Intracerebroventricular injection in the anterior hypothalamic-preoptic area (AHPOA) of rats; single dose; recorded 0, 10, 20, 30, 40, 50, and 60 min after injection
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Result:Showed greater difference than mean temperatures of animals receiving sterile saline group.
Chemical Information
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CAS No. 82188-67-8
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Appearance Solid
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Molecular Weight 985.10
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Formula C47H64N14O10
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Color White to off-white
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Sequence Shortening
Ac-{Nle}-EH-{d-Phe}-RWG-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (101.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0151 mL | 5.0756 mL | 10.1513 mL | 25.3781 mL |
| 5 mM | 0.2030 mL | 1.0151 mL | 2.0303 mL | 5.0756 mL | |
| 10 mM | 0.1015 mL | 0.5076 mL | 1.0151 mL | 2.5378 mL | |
| 15 mM | 0.0677 mL | 0.3384 mL | 0.6768 mL | 1.6919 mL | |
| 20 mM | 0.0508 mL | 0.2538 mL | 0.5076 mL | 1.2689 mL | |
| 25 mM | 0.0406 mL | 0.2030 mL | 0.4061 mL | 1.0151 mL | |
| 30 mM | 0.0338 mL | 0.1692 mL | 0.3384 mL | 0.8459 mL | |
| 40 mM | 0.0254 mL | 0.1269 mL | 0.2538 mL | 0.6345 mL | |
| 50 mM | 0.0203 mL | 0.1015 mL | 0.2030 mL | 0.5076 mL | |
| 60 mM | 0.0169 mL | 0.0846 mL | 0.1692 mL | 0.4230 mL | |
| 80 mM | 0.0127 mL | 0.0634 mL | 0.1269 mL | 0.3172 mL | |
| 100 mM | 0.0102 mL | 0.0508 mL | 0.1015 mL | 0.2538 mL |
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 Related Classifications
HY-P3662 Related Classifications
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