β-Sitostenone
Based on 1 Customer Validation
β-Sitostenone is a sterols that can be isolated from Cochlospermum vitifolium.β-Sitostenone inhibits tyrosinase activity, and has anti-melanogenic and anti-tumor activities.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 1058-61-3
- Formula: C29H48O
- Molecular Weight:412.69
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COLO 205 | IC50 |
>10 μM
Compound: 3
|
Cytotoxicity against human COLO205 cells after 24 hrs by MTT assay
Cytotoxicity against human COLO205 cells after 24 hrs by MTT assay
|
[PMID: 30199257] |
| COLO 320 | IC50 |
>10 μM
Compound: 3
|
Cytotoxicity against human COLO320 cells after 24 hrs by MTT assay
Cytotoxicity against human COLO320 cells after 24 hrs by MTT assay
|
[PMID: 30199257] |
| L5178Y | IC50 |
>10 μM
Compound: 3
|
Antiproliferative activity against mouse L5178Y cells after 72 hrs by MTT assay
Antiproliferative activity against mouse L5178Y cells after 72 hrs by MTT assay
|
[PMID: 30199257] |
| L5178Y | IC50 |
>10 μM
Compound: 3
|
Antiproliferative activity against mouse L5178Y cells harboring human ABCB1 after 72 hrs by MTT assay
Antiproliferative activity against mouse L5178Y cells harboring human ABCB1 after 72 hrs by MTT assay
|
[PMID: 30199257] |
| MRC5 | IC50 |
>10 μM
Compound: 3
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Cytotoxicity against human MRC5 cells after 24 hrs by MTT assay
Cytotoxicity against human MRC5 cells after 24 hrs by MTT assay
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[PMID: 30199257] |
| NIH3T3 | IC50 |
>10 μM
Compound: 3
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Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay
Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay
|
[PMID: 30199257] |
| RAW264.7 | IC50 |
15.9 μM
Compound: 114
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production
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[PMID: 31255927] |
Chemical Information
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CAS No. 1058-61-3
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Appearance Solid
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Molecular Weight 412.69
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Formula C29H48O
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Color White to off-white
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SMILES
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@@H](CC)C(C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(CC3)=CC(CC4)=O)C
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Synonyms
Δ4-Sitosterol-3-one; β-Rosasterol oxide
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 2.5 mg/mL (6.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Aguilar-Guadarrama AB, et al. Flavonoids, Sterols and Lignans from Cochlospermum vitifolium and Their Relationship with Its Liver Activity. Molecules. 2018 Aug 5;23(8):1952. [Content Brief]
[2]. Chu CW, et al. Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic Properties. Molecules. 2015 Jul 3;20(7):12166-74. [Content Brief]
[3]. Fan SQ, et al. Sarocladione, a unique 5,10:8,9-diseco-steroid from the deep-sea-derived fungus Sarocladium kiliense. Org Biomol Chem. 2019 Jun 18;17(24):5925-5928. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4231 mL | 12.1156 mL | 24.2313 mL | 60.5782 mL |
| 5 mM | 0.4846 mL | 2.4231 mL | 4.8463 mL | 12.1156 mL |
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