Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic Properties

  • Molecules. 2015 Jul 3;20(7):12166-74. doi: 10.3390/molecules200712166.
Chia-Wei Chu  1 ,  Chi-Ming Liu  2 ,  Mei-Ing Chung  3 ,  Chung-Yi Chen  4
Affiliations
  • 1. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. [email protected].
  • 2. Department of Nursing, Tzu Hui Institute of Technology, Pingtung County 926, Taiwan. [email protected].
  • 3. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. [email protected].
  • 4. Department of Nutrition and Health Science, School of Medical and Health Sciences, Fooyin University, Kaohsiung 831, Taiwan. [email protected].
PMID: 26151114 DOI: 10.3390/molecules200712166
Abstract

Seven compounds were extracted and purified from the roots of Michelia compressa var. lanyuensis. These compounds are liriodenine, (-)-N-acetylanonaine, pressalanine A, p-dihydroxybenzaldehyde, 3,4-dihydroxybenzoic acid, (-)-bornesitol and β-sitostenone. These compounds were screened for anti-proliferation and anti-tyrosinase activities in B16F10 cells. Liriodenine, pressalanine A, (-)-bornesitol and β-sitostenone displayed cytotoxicity at high concentration (100 μM), but liriodenine (5 μM), (-)-N-acetylanonaine (10 μM), and β-sitostenone (5 μM) inhibit Tyrosinase activity and reduce the melanin content in B16F10 cells without cytotoxicity, suggesting that liriodenine and β-sitostenone could be safe and potentially used in cosmetic skin whitening.

Keywords
Magnoliaceae; Michelia compressa var. lanyuensis; melanin; tyrosinase activity.
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