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Cat. No.: HY-N10575

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Bornesitol

Bornesitol is a natural cytotoxic agent found in Michelia compressa var. lanyuensis. Bornesitol exhibits cytotoxic and antiproliferative activities, and can be used in melanoma research.

For research use only. We do not sell to patients.

CAS No.: 484-71-9
Formula: C₇H₁₄O₆
Molecular Weight:194.18

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Bornesitol Chemical Structure

CAS No.: 484-71-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Bornesitol is a natural cytotoxic agent found in Michelia compressa var. lanyuensis. Bornesitol exhibits cytotoxic and antiproliferative activities, and can be used in melanoma research^[1].

In Vitro

Bornesitol (1-100 μM; 24 h) shows no cytotoxicity against B16F10 melanoma cells at concentrations of 1 μM or 10 μM after 24 h of incubation, but induces cytotoxicity at a concentration of 100 μM^[1].
Bornesitol (5 μM; 48 h) weakly inhibits tyrosinase activity in B16F10 melanoma cells after incubation at 5 μM for 48 h, with an inhibition rate of 3.06%^[1].
Bornesitol (5 μM; 48 h) exerts only an extremely weak inhibitory effect on melanin content in B16F10 melanoma cells, with an inhibition rate of 0.89% after 48 h of incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

B16F10 melanoma cells
Concentration:

1 μM; 10 μM; 100 μM
Incubation Time:

24 h
Result:

Did not reduce B16F10 cell viability relative to vehicle control at 1 μM and 10 μM.
Caused cytotoxicity, reducing cell viability relative to vehicle control at 100 μM.

Chemical Information

CAS No. 484-71-9
Molecular Weight 194.18
Formula C₇H₁₄O₆
SMILES

O(C)[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chu CW, et al. Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic Properties. Molecules (Basel, Switzerland). 2015 Jul 03;20(7):12166-74. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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