Benzylacetone (Synonyms: 4-Penylbutan-2-one)

Name: Benzylacetone
Brand: MedChemExpress
SKU: HY-W015616
Rating: 4.5 (1 reviews)

Cat. No.: HY-W015616 Purity: 99.93%: FAQs
Data Sheet SDS COA Handling Instructions

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Benzylacetone is an aromatic compound from agarwood. Benzylacetone exhibits potent and reversible antityrosinase (mushroom) activity， with IC₅₀s of 2.8 mM and 0.6 mM for monophenolase and diphenolase, respectively. Benzylacetone has appetite-enhancing and locomotor-reducing effects.

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Benzylacetone Chemical Structure

CAS No. : 2550-26-7

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5 g	USD 30	In-stock	Estimated Time of Arrival: December 31
10 g	USD 45	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Benzylacetone is an aromatic compound from agarwood^[1]. Benzylacetone exhibits potent and reversible antityrosinase (mushroom) activity， with IC₅₀s of 2.8 mM and 0.6 mM for monophenolase and diphenolase, respectively^[2]. Benzylacetone has appetite-enhancing and locomotor-reducing effects^[3].

IC₅₀ & Target

IC50: 2.8 mM (monophenolase, tyrosinase mushroom), 0.6 mM (diphenolase, tyrosinase mushroom)^[2]

Molecular Weight

148.21

Formula

C₁₀H₁₂O

CAS No.

2550-26-7

Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC(CCC1=CC=CC=C1)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (674.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.7472 mL	33.7359 mL	67.4718 mL
5 mM	1.3494 mL	6.7472 mL	13.4944 mL
10 mM	0.6747 mL	3.3736 mL	6.7472 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (16.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.93%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (246 KB) HNMR (122 KB) GC (218 KB)

Handling Instructions (2659 KB)

References

[1]. Takamatsu S, et al. Agarotetrol: a source compound for low molecular weight aromatic compounds from agarwood heating. J Nat Med. 2018 Mar;72(2):537-541. [Content Brief]

[2]. Liu X, et al. Inhibition effects of benzylideneacetone, benzylacetone, and 4-phenyl-2-butanol on the activity of mushroom tyrosinase. J Biosci Bioeng. 2015 Mar;119(3):275-9. [Content Brief]

[3]. Ogawa K, et al. Appetite-Enhancing Effects: The Influence of Concentrations of Benzylacetone and trans-Cinnamaldehyde and Their Inhalation Time, as Well as the Effect of Aroma, on Body Weight in Mice. Biol Pharm Bull. 2016;39(5):794-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.7472 mL	33.7359 mL	67.4718 mL	168.6796 mL
	5 mM	1.3494 mL	6.7472 mL	13.4944 mL	33.7359 mL
	10 mM	0.6747 mL	3.3736 mL	6.7472 mL	16.8680 mL
	15 mM	0.4498 mL	2.2491 mL	4.4981 mL	11.2453 mL
	20 mM	0.3374 mL	1.6868 mL	3.3736 mL	8.4340 mL
	25 mM	0.2699 mL	1.3494 mL	2.6989 mL	6.7472 mL
	30 mM	0.2249 mL	1.1245 mL	2.2491 mL	5.6227 mL
	40 mM	0.1687 mL	0.8434 mL	1.6868 mL	4.2170 mL
	50 mM	0.1349 mL	0.6747 mL	1.3494 mL	3.3736 mL
	60 mM	0.1125 mL	0.5623 mL	1.1245 mL	2.8113 mL
	80 mM	0.0843 mL	0.4217 mL	0.8434 mL	2.1085 mL
	100 mM	0.0675 mL	0.3374 mL	0.6747 mL	1.6868 mL

Benzylacetone Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benzylacetone2550-26-74-Penylbutan-2-oneTyrosinaseInhibitorinhibitorinhibit

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Benzylacetone (Synonyms: 4-Penylbutan-2-one)

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Benzylacetone Related Antibodies

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Biological Activity

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References

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Molarity Calculator

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Complete Stock Solution Preparation Table

Benzylacetone Related Classifications

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