2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. SIB-1553A

SIB-1553A is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A is also a selective neuronal nAChR ligand. SIB-1553A is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders.

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SIB-1553A

SIB-1553A 構造式

CAS 番号 : 191611-89-9

容量 価格（税別） 在庫状況 数量
1 mg $44 在庫あり
5 mg $146 在庫あり
10 mg $220 在庫あり
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SIB-1553A 関連抗体

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製品説明

SIB-1553A is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A is also a selective neuronal nAChR ligand. SIB-1553A is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders[1][2].

体外実験

SIB-1553A displaces the binding of [H]nicotine (NIC) to the rat brain nAChRs with an IC50 value of 110 nM[1].
In calcium flux assays, SIB-1553A (0.1-5 μM), shows a greater selectivity for beta4-subunit containing recombinant hnAChRs (alpha2beta4, alpha3beta4 and alpha4beta4) vs. beta2-subunit containing nAChRs (alpha4beta2 and alpha3beta2) both in terms of efficacy and potency[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SIB-1553A 関連抗体
体内実験

SIB-1553A (1-40 mg/kg; s.c.) produces dose-dependent increases in ACh levels[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (200-250 g)[3]
Dosage: 1, 2, 4, 10, 20 and 40 mg/kg
Administration: s.c.
Result: Induced hippocampal ACh release.
分子量

273.82

分子式

C13H20ClNOS
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

OC(C=C1)=CC=C1SCCC2N(CCC2)C.[H]Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : ≥ 100 mg/mL (365.20 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6520 mL 18.2602 mL 36.5203 mL
5 mM 0.7304 mL 3.6520 mL 7.3041 mL
10 mM 0.3652 mL 1.8260 mL 3.6520 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (365.20 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.09%

COA (245 KB) LCMS (121 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.6520 mL 18.2602 mL 36.5203 mL 91.3009 mL
5 mM 0.7304 mL 3.6520 mL 7.3041 mL 18.2602 mL
10 mM 0.3652 mL 1.8260 mL 3.6520 mL 9.1301 mL
15 mM 0.2435 mL 1.2173 mL 2.4347 mL 6.0867 mL
20 mM 0.1826 mL 0.9130 mL 1.8260 mL 4.5650 mL
25 mM 0.1461 mL 0.7304 mL 1.4608 mL 3.6520 mL
30 mM 0.1217 mL 0.6087 mL 1.2173 mL 3.0434 mL
40 mM 0.0913 mL 0.4565 mL 0.9130 mL 2.2825 mL
50 mM 0.0730 mL 0.3652 mL 0.7304 mL 1.8260 mL
60 mM 0.0609 mL 0.3043 mL 0.6087 mL 1.5217 mL
80 mM 0.0457 mL 0.2283 mL 0.4565 mL 1.1413 mL
100 mM 0.0365 mL 0.1826 mL 0.3652 mL 0.9130 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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SIB-1553A Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIB-1553A191611-89-9nAChRNicotinic acetylcholine receptorsAlzheimer’sdiseasecognitivedisorderscholinergicdeficitsmemoryInhibitorinhibitorinhibit

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