191611-89-9
191611-89-9
Chemical Structure
SIB-1553A
- CAS No.: 191611-89-9
- Formula:C13H20ClNOS
- Molecular Weight:273.82
IUPAC Name: 4-((2-(1-methylpyrrolidin-2-yl)ethyl)thio)phenol hydrochloride
InChIKey: RJSVKPQKXSMZMT-UHFFFAOYSA-N
SMILES: OC(C=C1)=CC=C1SCCC2N(CCC2)C.[H]Cl
Biological Activity: SIB-1553A is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A is also a selective neuronal nAChR ligand. SIB-1553A is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders[1][2].
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SIB-1553A | 99.0% | SIB-1553A is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A is also a selective neuronal nAChR ligand. SIB-1553A is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders. | ||||||||||||||||||||
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References
- [1]. Vernier JM, et al. 4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A): a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors. J Med Chem. 1999 May 20;42(10):1684-6. [Content Brief]
- [2]. Rao TS, et al. In vitro pharmacological characterization of (+/-)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a nicotinic acetylcholine receptor ligand. Brain Res. 2003 Aug 15;981(1-2):85-98. [Content Brief]
