1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. SIB-1553A

SIB-1553A 

Cat. No.: HY-107676
Handling Instructions

SIB-1553A is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A is also a selective neuronal nAChR ligand. SIB-1553A is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders.

For research use only. We do not sell to patients.

SIB-1553A Chemical Structure

SIB-1553A Chemical Structure

CAS No. : 191611-89-9

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10 mM * 1 mL in DMSO USD 286 In-stock
Estimated Time of Arrival: December 31
5 mg USD 475 In-stock
Estimated Time of Arrival: December 31
10 mg USD 810 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

SIB-1553A is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A is also a selective neuronal nAChR ligand. SIB-1553A is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders[1][2].

In Vitro

SIB-1553A displaces the binding of [H]nicotine (NIC) to the rat brain nAChRs with an IC50 value of 110 nM[1].
In calcium flux assays, SIB-1553A (0.1-5 μM), shows a greater selectivity for beta4-subunit containing recombinant hnAChRs (alpha2beta4, alpha3beta4 and alpha4beta4) vs. beta2-subunit containing nAChRs (alpha4beta2 and alpha3beta2) both in terms of efficacy and potency[2].

In Vivo

SIB-1553A (1-40 mg/kg; s.c.) produces dose-dependent increases in ACh levels[3].

Animal Model: Male Sprague-Dawley rats (200-250 g)[3]
Dosage: 1, 2, 4, 10, 20 and 40 mg/kg
Administration: s.c.
Result: Induced hippocampal ACh release.
Molecular Weight

273.82

Formula

C₁₃H₂₀ClNOS

CAS No.

191611-89-9

SMILES

OC(C=C1)=CC=C1SCCC2N(CCC2)C.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SIB-1553AnAChRNicotinic acetylcholine receptorsAlzheimer’sdiseasecognitivedisorderscholinergicdeficitsmemoryInhibitorinhibitorinhibit

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