2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Soclenicant

Soclenicant  (Synonyms: BNC210; IW-2143)

Cat. No.: HY-172236 Purity: 99.75%
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Handling Instructions Technical Support

Soclenicant (BNC210) is an orally active α7 nAChR negative alteration modulator (NAM) with no apparent side effects. Soclenicant exhibits acute anxiolytic activity in rodent models of anxiety. Soclenicant inhibits rat and human α7 nAChR currents (in stably transfected cell lines) induced by acetylcholine, nicotine, choline, and the a7-specific agonist PNU-282987 (HY-12560A) with IC50 values in the range of 1.2 to 3 μM. Soclenicant can be used in studies of anxiety, trauma, and stressor-related disorders.

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Soclenicant

Soclenicant 화학구조

CAS No. : 1020634-41-6

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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Soclenicant Related Antibodies

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제품 설명

Soclenicant (BNC210) is an orally active α7 nAChR negative alteration modulator (NAM) with no apparent side effects. Soclenicant exhibits acute anxiolytic activity in rodent models of anxiety. Soclenicant inhibits rat and human α7 nAChR currents (in stably transfected cell lines) induced by acetylcholine, nicotine, choline, and the a7-specific agonist PNU-282987 (HY-12560A) with IC50 values in the range of 1.2 to 3 μM. Soclenicant can be used in studies of anxiety, trauma, and stressor-related disorders[1][2][3][4].

In Vivo

Soclenicant (BNC210) (0.1-10 mg/kg) increases the time spent and the distance travelled in the open arms of the maze in mice[4].

Mean pharmacokinetic parameters following oral administration of Soclenicant (BNC210) to male Sprague Dawley rats at doses of 0.5, 5 and 100 mg/kg[3]

Parameter Measured Dose (mg/kg) Apparent thalf (h) Cmax (μM) Tmax (min) AUC0-tlast (μM*min) AUC0-inf (μM*min) AUC0-inf/D (μM*min*kg/μmol) Apparent BA (%) % Dose in urine
0.5 mg/kg 0.55 c.n.c. 0.2 30 53.8 c.n.c. 41.4 66.7 1.6
5 mg/kg 4.8 8.8 1.1 30/300/30 496.8 497.6 43.7 70.3 0.7
100 mg/kg 102.4 6.3 5.7 150 3055.1 3062.9 12.5 13.2 0.2

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
분자량

418.49

화학식

C24H26N4O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=CC(NC3CC4=C(C3)C=CC=C4)=CN=C2N(CC)C=C1C(N5CCOCC5)=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 10 mg/mL (23.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3895 mL 11.9477 mL 23.8954 mL
5 mM 0.4779 mL 2.3895 mL 4.7791 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3895 mL 11.9477 mL 23.8954 mL 59.7386 mL
5 mM 0.4779 mL 2.3895 mL 4.7791 mL 11.9477 mL
10 mM 0.2390 mL 1.1948 mL 2.3895 mL 5.9739 mL
15 mM 0.1593 mL 0.7965 mL 1.5930 mL 3.9826 mL
20 mM 0.1195 mL 0.5974 mL 1.1948 mL 2.9869 mL
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Soclenicant Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Soclenicant1020634-41-6BNC210 IW-2143BNC 210BNC-210IW2143IW 2143IW-2143nAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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상품명:
Soclenicant
Cat. No.:
HY-172236
수량:
MCE Japan Authorized Agent:

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