Spexin  (Synonyms: Neuropeptide Q)

Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy^[1][2][3].

Spexin (1 μM; 24 h) increases viability and reduces apoptosis in neonatal rat cardiomyocytes (NRCs) treated with Doxorubicin (HY-15142A), reverses the loss of mitochondrial membrane potential and upregulates GPX4/SLC7A11^[2].
Spexin (20 ng/mL; 2 h) inhibits long-chain fatty acid (LCFA) uptake in isolated mouse adipocytes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Spexin (50 μg/kg; ip; once daily; 4 weeks) improves cardiac function and reduces oxidative stress in a mouse cardiotoxicity model induced by Doxorubicin hydrochloride (5 mg/kg/week; 4 weeks; ip)^[2].
Spexin (35 μg/kg/day; subcutaneous injection; 19 days) reduces food intake and weight gain in male Sprague-Dawley rats^[3].
Spexin (25 μg/kg/day; ip; 10 days) significantly reduces nocturnal respiratory exchange ratio (RER) and increases exercise capacity in mice^[3].
Spexin (70 μg/kg/day; ip; single dose) does not induce aversive effects in a conditioned taste aversion test in female rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1619.88

C₇₄H₁₁₄N₂₀O₁₉S

1370290-58-6

Solid

White to off-white

NWTPQAMLYLKGAQ-NH2

Room temperature in continental US; may vary elsewhere.

polypeptide, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Porzionato A, et al. Spexin expression in normal rat tissues. J Histochem Cytochem. 2010;58(9):825-837.  [Content Brief]

  [2]. Ou W, et al. Spexin inhibits excessive autophagy-induced ferroptosis to alleviate doxorubicin-induced cardiotoxicity by upregulating Beclin 1. Br J Pharmacol. 2024 Nov;181(21):4195-4213.  [Content Brief]

  [3]. Walewski JL, et al. Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity. Obesity (Silver Spring). 2014 Jul;22(7):1643-52.  [Content Brief]