1370290-58-6
Chemical Structure
Spexin
Synonym(s): Neuropeptide Q
- CAS No.: 1370290-58-6
- Formula:C74H114N20O19S
- Molecular Weight:1619.88
IUPAC Name: (S)-2-((S)-1-(L-asparaginyl-L-tryptophyl-L-threonyl)pyrrolidine-2-carboxamido)-N1-((S)-1-(((S)-1-(((S)-1-(((S)-1-(((S)-1-(((S)-6-amino-1-((2-(((S)-1-(((S)-1,5-diamino-1,5-dioxopentan-2-yl)amino)-1-oxopropan-2-yl)amino)-2-oxoethyl)amino)-1-oxohexan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-4-(methylthio)-1-oxobutan-2-yl)amino)-1-oxopropan-2-yl)pentanediamide
InChIKey: ZZDZBDJTNIOJMF-TWMPYRTRSA-N
SMILES: O=C(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CCSC)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(NCC(N[C@@H](C)C(N[C@H](C(N)=O)CCC(N)=O)=O)=O)=O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)NC([C@@H](NC([C@@H](N)CC(N)=O)=O)CC3=CNC4=CC=CC=C34)=O
Biological Activity: Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Spexin | 99.12% | Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy. | ||||||||||||||||||||
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- [1]. Porzionato A, et al. Spexin expression in normal rat tissues. J Histochem Cytochem. 2010;58(9):825-837. [Content Brief]
- [2]. Ou W, et al. Spexin inhibits excessive autophagy-induced ferroptosis to alleviate doxorubicin-induced cardiotoxicity by upregulating Beclin 1. Br J Pharmacol. 2024 Nov;181(21):4195-4213. [Content Brief]
- [3]. Walewski JL, et al. Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity. Obesity (Silver Spring). 2014 Jul;22(7):1643-52. [Content Brief]
Keywords
