TAM-16

Name: TAM-16
Brand: MedChemExpress
SKU: HY-116838
Rating: 4.5 (0 reviews)

Cat. No.: HY-116838 Purity: 99.13%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

TAM-16 is a potent and orally active polyketide synthase 13 (Pks13) inhibitor with an IC₅₀ value of 0.32 μM. TAM-16 has promising activity against Mycobacterium tuberculosis. TAM-16 inhibits hERG cardiac ion channel.

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TAM-16 화학구조

CAS No. : 2030241-59-7

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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Biological Activity
순도&문서
References
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제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	CC₅₀	>1024 μM Compound: TAM16	Cytotoxicity against CHO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against CHO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31525660]
Fibroblast	CC₅₀	>100 μM Compound: 73	Cytotoxicity against human dermal fibroblasts assessed as cell growth inhibition treated for 48 hrs by resazurin dye based assay Cytotoxicity against human dermal fibroblasts assessed as cell growth inhibition treated for 48 hrs by resazurin dye based assay	[PMID: 35612311]
HepG2	IC₅₀	>100 μM Compound: 1	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by resazurin dye based assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by resazurin dye based assay	[PMID: 34910486]
Vero	CC₅₀	>1024 μg/mL Compound: TAM16	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30690301]
Vero	CC₅₀	>1024 μM Compound: TAM16	Cytotoxicity against African green monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 30992202]

In Vitro

TAM-16 (compound 1) inhibits the growth of M. tuberculosis strain H37Rv with an IC₅₀ value of 0.08 μM^[1].
TAM-16 (0-10 μM) inhibits Mycobacterium tuberculosis by targeting Pks13^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TAM-16 (compound 1; 200 mg/kg; p.o.; daily, for 14 days) prevents the development of characteristic lung lesions in murine TB infection models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c mice with tuberculosis (TB) model^[2]
Dosage:	200 mg/kg
Administration:	oral administration; daily, for 14 days
Result:	Had a significant reduction in lung CFU counts by ∼0.9 log₁₀ compared with the untreated control mice

분자량

380.44

화학식

C₂₂H₂₄N₂O₄

CAS No.

2030241-59-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C2=CC=C(O)C=C2)OC3=CC=C(O)C(CN4CCCCC4)=C13)NC

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 125 mg/mL (328.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6285 mL	13.1427 mL	26.2854 mL
5 mM	0.5257 mL	2.6285 mL	5.2571 mL
10 mM	0.2629 mL	1.3143 mL	2.6285 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.13%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (251 KB) HNMR (262 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Scullion P, et, al. Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target. J Med Chem. 2022 Jan 13;65(1):409-423. [Content Brief]

[2]. Aggarwal A, et, al. Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. Cell. 2017 Jul 13;170(2):249-259.e25. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6285 mL	13.1427 mL	26.2854 mL	65.7134 mL
	5 mM	0.5257 mL	2.6285 mL	5.2571 mL	13.1427 mL
	10 mM	0.2629 mL	1.3143 mL	2.6285 mL	6.5713 mL
	15 mM	0.1752 mL	0.8762 mL	1.7524 mL	4.3809 mL
	20 mM	0.1314 mL	0.6571 mL	1.3143 mL	3.2857 mL
	25 mM	0.1051 mL	0.5257 mL	1.0514 mL	2.6285 mL
	30 mM	0.0876 mL	0.4381 mL	0.8762 mL	2.1904 mL
	40 mM	0.0657 mL	0.3286 mL	0.6571 mL	1.6428 mL
	50 mM	0.0526 mL	0.2629 mL	0.5257 mL	1.3143 mL
	60 mM	0.0438 mL	0.2190 mL	0.4381 mL	1.0952 mL
	80 mM	0.0329 mL	0.1643 mL	0.3286 mL	0.8214 mL
	100 mM	0.0263 mL	0.1314 mL	0.2629 mL	0.6571 mL

TAM-16 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAM-162030241-59-7TAM16TAM 16BacterialInhibitorinhibitorinhibit

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TAM-16

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TAM-16 Related Antibodies

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Biological Activity

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TAM-16 Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

TAM-16 Related Classifications

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SAFETY DATA SHEET (SDS)

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