2030241-59-7
2030241-59-7
Chemical Structure
TAM-16
- CAS No.: 2030241-59-7
- Formula:C22H24N2O4
- Molecular Weight:380.44
IUPAC Name: 5-hydroxy-2-(4-hydroxyphenyl)-N-methyl-4-(piperidin-1-ylmethyl)benzofuran-3-carboxamide
InChIKey: PQGCMFVNJWTUFH-UHFFFAOYSA-N
SMILES: O=C(C1=C(C2=CC=C(O)C=C2)OC3=CC=C(O)C(CN4CCCCC4)=C13)NC
Biological Activity: TAM-16 is a potent and orally active polyketide synthase 13 (Pks13) inhibitor with an IC50 value of 0.32 μM. TAM-16 has promising activity against Mycobacterium tuberculosis. TAM-16 inhibits hERG cardiac ion channel[1][2].
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TAM-16 | 99.13% | TAM-16 is a potent and orally active polyketide synthase 13 (Pks13) inhibitor with an IC50 value of 0.32 μM. TAM-16 has promising activity against Mycobacterium tuberculosis. TAM-16 inhibits hERG cardiac ion channel. | ||||||||||||||||||||
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References
- [1]. Scullion P, et, al. Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target. J Med Chem. 2022 Jan 13;65(1):409-423. [Content Brief]
- [2]. Aggarwal A, et, al. Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. Cell. 2017 Jul 13;170(2):249-259.e25. [Content Brief]
Keywords
