TAM-16

Cat. No.: HY-116838: FAQs
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TAM-16 is a potent and orally active polyketide synthase 13 (Pks13) inhibitor with an IC₅₀ value of 0.32 μM. TAM-16 has promising activity against Mycobacterium tuberculosis. TAM-16 inhibits hERG cardiac ion channel.

For research use only. We do not sell to patients.

TAM-16 Chemical Structure

CAS No. : 2030241-59-7

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Description

In Vitro

TAM-16 (compound 1) inhibits the growth of M. tuberculosis strain H37Rv with an IC₅₀ value of 0.08 μM^[1].
TAM-16 (0-10 μM) inhibits Mycobacterium tuberculosis by targeting Pks13^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TAM-16 (compound 1; 200 mg/kg; p.o.; daily, for 14 days) prevents the development of characteristic lung lesions in murine TB infection models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c mice with tuberculosis (TB) model^[2]
Dosage:	200 mg/kg
Administration:	oral administration; daily, for 14 days
Result:	Had a significant reduction in lung CFU counts by ∼0.9 log₁₀ compared with the untreated control mice

Molecular Weight

380.44

Formula

C₂₂H₂₄N₂O₄

CAS No.

2030241-59-7

SMILES

O=C(C1=C(C2=CC=C(O)C=C2)OC3=CC=C(O)C(CN4CCCCC4)=C13)NC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Scullion P, et, al. Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target. J Med Chem. 2022 Jan 13;65(1):409-423. [Content Brief]

[2]. Aggarwal A, et, al. Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. Cell. 2017 Jul 13;170(2):249-259.e25. [Content Brief]

TAM-16 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAM-162030241-59-7TAM16TAM 16BacterialInhibitorinhibitorinhibit

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