TC OT 39 

TC OT 39 is a synthetic oxytocin analog, as well as a selective agonist of oxytocin receptor (OXTR, EC₅₀=180 nM). TC OT 39 is also an Avprla vasopressin receptor antagonist with an K_i value of 330 nM. TC OT 39 exhibits sedative effects in mouse models^[1].

TC OT 39 (50 mg/kg, 75 mg/kg; i.p.; 4 times during 8-9 days) significantly decreases the marble burying at dose of 50 mg/kg, and shows overt sedative-like effects at dose of 75 mg/kg in C57BL/6J mice^[1].
Marble burying is based on the natural instinct of rodents to bury objects, commonly used in preclinical research to assess anxiety-like behavior in rodents^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

600.78

C₃₂H₄₀N₈O₂S

479232-57-0

Solid

White to off-white

O=C(N1[C@H](C(N2CCN(C)CCC2)=S)CCC1)NCC3=CC=C(C(N4CC5=C(N(C)N=C5)NC6=CC=CC=C46)=O)C=C3C

Room temperature in continental US; may vary elsewhere.

• [1]. Moy SS, et al. Prosocial effects of an oxytocin metabolite, but not synthetic oxytocin receptor agonists, in a mouse model of autism. Neuropharmacology. 2019 Jan;144:301-311.  [Content Brief]