2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Tislelizumab

Tislelizumab  (Synonyms: BGB-A317)

製品番号: HY-P99052 純度: 98.10%
COA Technical Support

Tislelizumab is a monoclonal antibody that specifically binds to programmed cell death receptor 1 (PD-1), blocking its interaction with programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2). Tislelizumab can reactivate immune cells such as T lymphocytes and enhance anti-tumor activity. Tislelizumab can be used for the research of a variety of tumors including typical Hodgkin's lymphoma, urothelial carcinoma, non-small cell lung cancer and hepatocellular carcinoma.

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CAS 番号 : 1858168-59-8

容量 価格（税別） 在庫状況 数量
>無料サンプル (100 μg)   今すぐ申し込む  
1 mg $120 在庫あり
5 mg $350 在庫あり
10 mg $550 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

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Based on 3 publication(s) in Google Scholar

Tislelizumab Featured Recommendations:

Tislelizumab 関連抗体

Top Publications Citing Use of Products

    Tislelizumab purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2024 Jun 29;24(1):225.  [Abstract]

    Tislelizumab (50 µg/mL; 24 h). IFN-γ concentration in the supernatant of co-cultured cell lines was assessed by ELISA.

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    製品説明

    Tislelizumab is a monoclonal antibody that specifically binds to programmed cell death receptor 1 (PD-1), blocking its interaction with programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2). Tislelizumab can reactivate immune cells such as T lymphocytes and enhance anti-tumor activity. Tislelizumab can be used for the research of a variety of tumors including typical Hodgkin's lymphoma, urothelial carcinoma, non-small cell lung cancer and hepatocellular carcinoma[1][2][3].

    Isotype

    Human IgG4 kappa
    Recommend Isotype Controls
    Species Reactivity

    Human
    IC50 & Target

    PDCD1/PD-1/CD279
    体内実験

    Tislelizumab (10 mg/kg; Intraperitoneal injection; Once a week; 4 weeks) has significant antitumor effect in the B16F10 melanoma mouse model[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: B16F10/GM-CSF tumor cells treated hPD-1 C57BL/6 transgenic mice[2]
    Dosage: 10 mg/kg
    Administration: Intraperitoneal injection (i.p.); once a week for 4 weeks.
    Result: Exerted remarkable antitumor efficacy, resulting in approximate 86.7% tumor growth inhibition.
    臨床実験
    Gene ID

    5133  [NCBI]

    Accession
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    分子量

    145 kDa

    CAS 番号
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Tislelizumab]
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    保管条件

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • Human IgG4 kappa
    Biological Activity
    • Flow cytometry analysis of PD-1 overexpression Jurkat cells labelling PD-1 with Tislelizumab at 20 nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
    純度とドキュメンテーション

    純度: 98.10%

    COA (232 KB)

    Inhibitory Antibodies User Guide (603 KB)
    参考文献
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Tislelizumab Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Tislelizumab1858168-59-8BGB-A317PD-1/PD-L1PD-1/Programmed death-ligand 1monoclonal antibodyPD-1 receptorminimizes Fcγ receptor binding on macrophagesadvanced squamous non-small-cell lung cancerInhibitorinhibitorinhibit

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    製品名:
    Tislelizumab
    製品番号:
    HY-P99052
    数量:
    MCE 日本正規代理店:

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