Urea-¹⁵N₂ (Synonyms: Carbonyl diamide-¹⁵N₂)

Name: Urea- 15 N 2
Brand: MedChemExpress
SKU: HY-Y0271S
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Cat. No.: HY-Y0271S Pureté: 99.80%: Fiche technique
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Urea-¹⁵N₂ is the ¹⁵N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms. A potent emollient and keratolytic agent. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

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Urea-¹⁵N₂ Chemical Structure

CAS No. : 2067-80-3

Size	Stock	Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtenir un devis
500 mg	Obtenir un devis

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Other Forms of Urea-¹⁵N₂:

Urea In-stock
Urea-¹³C,¹⁵N Obtenir un devis

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Description

Urea-¹⁵N₂ is the ¹⁵N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms^[1]. A potent emollient and keratolytic agent^[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function^[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

62.04

Formule

CH₄¹⁵N₂O

CAS No.

2067-80-3

Unlabeled CAS

57-13-6

Appearance

Solid

Color

White to off-white

SMILES

[15NH2]C([15NH2])=O

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (1611.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	16.1186 mL	80.5932 mL	161.1863 mL
5 mM	3.2237 mL	16.1186 mL	32.2373 mL
10 mM	1.6119 mL	8.0593 mL	16.1186 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Calculation results:

Working solution concentration: mg/mL

Pureté et documentation

Purity: 99.80%

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Fiche technique (269 KB) SDS (254 KB)

COA (244 KB) RP-HPLC (247 KB) MS (119 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Bennion BJ, et al. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5142-7. [Content Brief]

[3]. Pan M, et al. Urea: a comprehensive review of the clinical literature. Dermatol Online J. 2013 Nov 15;19(11):20392. [Content Brief]

[4]. Wang H, et al. Urea. Subcell Biochem. 2014;73:7-29. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	16.1186 mL	80.5932 mL	161.1863 mL	402.9658 mL
	5 mM	3.2237 mL	16.1186 mL	32.2373 mL	80.5932 mL
	10 mM	1.6119 mL	8.0593 mL	16.1186 mL	40.2966 mL
	15 mM	1.0746 mL	5.3729 mL	10.7458 mL	26.8644 mL
	20 mM	0.8059 mL	4.0297 mL	8.0593 mL	20.1483 mL
	25 mM	0.6447 mL	3.2237 mL	6.4475 mL	16.1186 mL
	30 mM	0.5373 mL	2.6864 mL	5.3729 mL	13.4322 mL
	40 mM	0.4030 mL	2.0148 mL	4.0297 mL	10.0741 mL
	50 mM	0.3224 mL	1.6119 mL	3.2237 mL	8.0593 mL
	60 mM	0.2686 mL	1.3432 mL	2.6864 mL	6.7161 mL
	80 mM	0.2015 mL	1.0074 mL	2.0148 mL	5.0371 mL
	100 mM	0.1612 mL	0.8059 mL	1.6119 mL	4.0297 mL

Urea-¹⁵N₂ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Urea-¹⁵N₂2067-80-3Carbonyl diamide-¹⁵N₂Endogenous MetaboliteInhibitorinhibitorinhibit

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Urea-15N2 (Synonyms: Carbonyl diamide-15N2)

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Other Forms of Urea-15N2:

Urea-15N2 Related Antibodies

Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform Endogenous Metabolite:

Activité biologique

Pureté et documentation

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Urea-15N2 Related Antibodies

Calculateur de molarité

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Complete Stock Solution Preparation Table

Urea-15N2 Related Classifications

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Urea-¹⁵N₂ (Synonyms: Carbonyl diamide-¹⁵N₂)

Other Forms of Urea-¹⁵N₂:

Urea-¹⁵N₂ Related Antibodies

Urea-¹⁵N₂ Related Antibodies

Urea-¹⁵N₂ Related Classifications