2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. VU590

VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

VU590

VU590 構造式

CAS 番号 : 313505-85-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 81 在庫あり
Solution
10 mM * 1 mL in DMSO USD 81 在庫あり
Solid
5 mg $75 在庫あり
10 mg $120 在庫あり
25 mg $200 在庫あり
50 mg $300 在庫あり
100 mg $450 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 2 publication(s) in Google Scholar

Other Forms of VU590:

VU590 関連抗体

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製品説明

VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney[1][2].

IC50 & Target

IC50: 290 nM (Kir1.1), 8 μM (Kir7.1)[1]
Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
294 1
Compound: 1; VU590
Inhibition of rat ROMK1 expressed in HEK293 cells by Tl+ flux assay
Inhibition of rat ROMK1 expressed in HEK293 cells by Tl+ flux assay
[PMID: 31034224]
HEK293 IC50
294 1
Compound: 1; VU590
Inhibition of rat ROMK1 expressed in HEK293 cells by Tl+ flux assay
Inhibition of rat ROMK1 expressed in HEK293 cells by Tl+ flux assay
[PMID: 31034224]
分子量

488.53

分子式

C24H32N4O7
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

[O-][N+](C1=CC=C(C=C1)CN(CCOCCOCC2)CCOCCN2CC(C=C3)=CC=C3[N+]([O-])=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (102.35 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0470 mL 10.2348 mL 20.4696 mL
5 mM 0.4094 mL 2.0470 mL 4.0939 mL
10 mM 0.2047 mL 1.0235 mL 2.0470 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0470 mL 10.2348 mL 20.4696 mL 51.1739 mL
5 mM 0.4094 mL 2.0470 mL 4.0939 mL 10.2348 mL
10 mM 0.2047 mL 1.0235 mL 2.0470 mL 5.1174 mL
15 mM 0.1365 mL 0.6823 mL 1.3646 mL 3.4116 mL
20 mM 0.1023 mL 0.5117 mL 1.0235 mL 2.5587 mL
25 mM 0.0819 mL 0.4094 mL 0.8188 mL 2.0470 mL
30 mM 0.0682 mL 0.3412 mL 0.6823 mL 1.7058 mL
40 mM 0.0512 mL 0.2559 mL 0.5117 mL 1.2793 mL
50 mM 0.0409 mL 0.2047 mL 0.4094 mL 1.0235 mL
60 mM 0.0341 mL 0.1706 mL 0.3412 mL 0.8529 mL
80 mM 0.0256 mL 0.1279 mL 0.2559 mL 0.6397 mL
100 mM 0.0205 mL 0.1023 mL 0.2047 mL 0.5117 mL
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VU590 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU590313505-85-0VU 590VU-590Potassium ChannelKcsAPotassium (K+) ChannelRenal outer medullary potassium channel (ROMK)Inward rectifier potassium (Kir)Diuretic targetInhibitorinhibitorinhibit

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製品名:
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製品番号:
HY-108595
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