2. Anti-infection
  3. Parasite
  4. Xestoquinone

Xestoquinone ((+)-Xestoquinone) is a Plasmodium falciparum protein kinase Pfnek-1 inhibitor (IC50=1.1 μM). Xestoquinone is promising for research of antimalarial agents.

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Xestoquinone

Xestoquinone Chemical Structure

CAS No. : 97743-96-9

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Xestoquinone Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Description

Xestoquinone ((+)-Xestoquinone) is a Plasmodium falciparum protein kinase Pfnek-1 inhibitor (IC50=1.1 μM). Xestoquinone is promising for research of antimalarial agents[1][2].

Cellular Effect
Cell Line Type Value Description References
786-0 EC50
>100 3
Compound: 3
Inhibition of HIF2alpha in human 786-0 cells expressing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter gene assay
Inhibition of HIF2alpha in human 786-0 cells expressing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter gene assay
[PMID: 22928967]
KB IC50
1.7 6
Compound: 6
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
10.1021/np50085a028
L1210 IC50
0.17 6
Compound: 6
Cytotoxicity against mouse L1210 cells
Cytotoxicity against mouse L1210 cells
10.1021/np50085a028
MDA-MB-231 IC50
20.6 3
Compound: 4
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
[PMID: 22938093]
T47D IC50
13.8 3
Compound: 4
Cytotoxicity against human T47D cells after 48 hrs by SRB assay
Cytotoxicity against human T47D cells after 48 hrs by SRB assay
[PMID: 22938093]
T47D IC50
7.3 3
Compound: 4
Inhibition of 1,10-phenanthroline-induced HIF1 activation in human T47D cells after 16 hrs by HRE3-TK-luciferase reporter gene assay
Inhibition of 1,10-phenanthroline-induced HIF1 activation in human T47D cells after 16 hrs by HRE3-TK-luciferase reporter gene assay
[PMID: 22938093]
T47D IC50
12.3 3
Compound: 4
Inhibition of hypoxia-induced HIF1 activation in human T47D cells after 16 hrs by HRE3-TK-luciferase reporter gene assay
Inhibition of hypoxia-induced HIF1 activation in human T47D cells after 16 hrs by HRE3-TK-luciferase reporter gene assay
[PMID: 22938093]
Molecular Weight

318.32

Formula

C20H14O4
CAS No.
SMILES

C[C@@]12C3=C(OC=C3CCC2)C(C4=CC(C(C=CC5=O)=O)=C5C=C41)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Xestoquinone Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xestoquinone97743-96-9(+)-XestoquinoneParasitePfnek-1antimalarial agentsInhibitorinhibitorinhibit

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