2. PROTAC Epigenetics
  3. PROTACs WDR5
  4. XF067-68

XF067-68 (example 132) is a PROTAC for targeted degradation of WD40 repeat domain protein 5 (WDR5). XF067-68 can be usde for the study of WDR5-mediated diseases.
(Pink: WDR5 ligand (HY-141799); Blue: VHL ligand (HY-173627); Black: linker (HY-Y0966)).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

XF067-68

XF067-68 화학구조

CAS No. : 2407452-79-1

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg   견적 받기  
200 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

XF067-68 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

XF067-68 (example 132) is a PROTAC for targeted degradation of WD40 repeat domain protein 5 (WDR5). XF067-68 can be usde for the study of WDR5-mediated diseases[1]. (Pink: WDR5 ligand (HY-141799); Blue: VHL ligand (HY-173627); Black: linker (HY-Y0966)).

IC50 & Target

WDR5[1]
In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

XF067-68 Related Antibodies
분자량

1030.14

화학식

C52H59F4N9O7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C(C(F)(F)F)=C1)=CNC1=O)NC2=C(N3C[C@H](N([C@H](C3)C)C)C)C=CC(C4=CC(C(NCC(N[C@@H](C(C)(C)C)C(N5[C@H](C[C@@H](C5)O)C(N[C@H](C6=CC=C(C7=C(N=CS7)C)C=C6)C)=O)=O)=O)=O)=CC=C4F)=C2
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : ≥ 100 mg/mL (97.07 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9707 mL 4.8537 mL 9.7074 mL
5 mM 0.1941 mL 0.9707 mL 1.9415 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9707 mL 4.8537 mL 9.7074 mL 24.2685 mL
5 mM 0.1941 mL 0.9707 mL 1.9415 mL 4.8537 mL
10 mM 0.0971 mL 0.4854 mL 0.9707 mL 2.4269 mL
15 mM 0.0647 mL 0.3236 mL 0.6472 mL 1.6179 mL
20 mM 0.0485 mL 0.2427 mL 0.4854 mL 1.2134 mL
25 mM 0.0388 mL 0.1941 mL 0.3883 mL 0.9707 mL
30 mM 0.0324 mL 0.1618 mL 0.3236 mL 0.8090 mL
40 mM 0.0243 mL 0.1213 mL 0.2427 mL 0.6067 mL
50 mM 0.0194 mL 0.0971 mL 0.1941 mL 0.4854 mL
60 mM 0.0162 mL 0.0809 mL 0.1618 mL 0.4045 mL
80 mM 0.0121 mL 0.0607 mL 0.1213 mL 0.3034 mL
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XF067-68 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XF067-682407452-79-1PROTACsWDR5WD repeat protein-5WD40 repeat domain protein 5 relapsed cancerInhibitorinhibitorinhibit

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Inquiry Information

상품명:
XF067-68
Cat. No.:
HY-150403
수량:
MCE Japan Authorized Agent:

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