2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Z21115

Z21115 is an orally active inhibitor for phosphodiesterase 4 (PDE4), that inhibits PDE4D7 with IC50 of 10.5 nM. Z21115 inhibits Lipopolysaccharide (HY-D1056)-induced expression of IL-6, TNF-α and iNOS. Z21115 exhibits anti-inflammatory activity in DSS (HY-116282)-induced mouse colitis models without significant toxicity (1 g/kg).

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Z21115

Z21115 Chemical Structure

CAS No. : 2958668-54-5

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Z21115 Related Antibodies

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

Z21115 is an orally active inhibitor for phosphodiesterase 4 (PDE4), that inhibits PDE4D7 with IC50 of 10.5 nM. Z21115 inhibits Lipopolysaccharide (HY-D1056)-induced expression of IL-6, TNF-α and iNOS. Z21115 exhibits anti-inflammatory activity in DSS (HY-116282)-induced mouse colitis models without significant toxicity (1 g/kg)[1].

IC50 & Target

PDE4D7

10.5 nM (IC50)

PDE4D

65.7 nM (IC50)

PDE4B

64.4 nM (IC50)

Masse moléculaire

390.38

Formule

C20H20F2N2O4
CAS No.
SMILES

COC1=C(OC)C=C(C2=CC=C(OC(F)F)C3=NN(C4CC4)C=C23)C=C1OC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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Z21115 Related Classifications

  • Calculateur de molarité

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z211152958668-54-5Z 21115Z-21115Phosphodiesterase (PDE)RAW264.7orally activeC57BL/6J mousecolitisInhibitorinhibitorinhibit

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Z21115
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HY-161936
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