2. Others Membrane Transporter/Ion Channel Apoptosis Anti-infection
  3. Proton Pump Fungal Environmental Pollutants Bacterial Cuproptosis
  4. Zinc Pyrithione

Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump. Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis.

For research use only. We do not sell to patients.

CAS No. : 13463-41-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
500 mg In-stock
1 g In-stock
5 g In-stock
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Customer Review

Based on 12 publication(s) in Google Scholar

Other Forms of Zinc Pyrithione:

Zinc Pyrithione Related Antibodies

Top Publications Citing Use of Products

    Zinc Pyrithione purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2024 Aug 22;20(8):e1012444.  [Abstract]

    WT or KO Huh7.5.1-VP30 cells were infected with EBOVΔVP30-EGFP (MOI = 1) in the presence of TPEN or (Zinc Pyrithione) ZnPy for 2 days. EGFP was quantified by flow cytometry to determine the inhibitory effect.

    Zinc Pyrithione purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2024 Aug 22;20(8):e1012444.  [Abstract]

    Huh7.5.1-VP30 cells were treated with (Zinc Pyrithione) ZnPy for 4h or 2d at indicated concentrations before RNA extraction. MT1A and MT2A mRNA level were then quantified by RT-qPCR. mRNA level was represented as normalization to GAPDH.

    Zinc Pyrithione purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2022 Apr 1:234:113393.  [Abstract]

    Fully mature GV stage oocytes were co-cultured with different concentrations (0, 0.8, 1.4, 2.0 µM) of ZPT for 14 hours. Most oocytes in the control group and the 0.8 µM ZPT (Zinc Pyrithione) treatment group reached maturity and formed the first polar body (a representative oocyte marked with a triangle).

    Zinc Pyrithione purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2022 Apr 1:234:113393.  [Abstract]

    Expression of α-tubulin in oocytes of the control group and the ZPT (Zinc Pyrithione) treatment group. Oocytes from both groups were lysed after 8 hours of culture and subjected to Western blot analysis. GAPDH was used as an internal control.

    Zinc Pyrithione purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2022 Apr 1:234:113393.  [Abstract]

    ZPT (Zinc Pyrithione) exposure impairs p-MAPK activity during meiosis in mice. Images show the localization and expression of p-MAPK in oocytes of the control and ZPT-treated groups.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump[1]. Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis[2].

    In Vitro

    Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM[1].
    Zinc Pyrithione (10 nM-10 μM; 72 hours) significantly induces cell death in AAVS1 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Zinc Pyrithione Related Antibodies
    Molecular Weight

    317.69

    Formula

    C10H8N2O2S2Zn
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    N12[O-][Zn+2]3([S]=C1C=CC=C2)[O-]N(C=CC=C4)C4=[S]3
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 33.33 mg/mL (104.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1477 mL 15.7386 mL 31.4772 mL
    5 mM 0.6295 mL 3.1477 mL 6.2954 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    Volume (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (7.87 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.1477 mL 15.7386 mL 31.4772 mL 78.6931 mL
    5 mM 0.6295 mL 3.1477 mL 6.2954 mL 15.7386 mL
    10 mM 0.3148 mL 1.5739 mL 3.1477 mL 7.8693 mL
    15 mM 0.2098 mL 1.0492 mL 2.0985 mL 5.2462 mL
    20 mM 0.1574 mL 0.7869 mL 1.5739 mL 3.9347 mL
    25 mM 0.1259 mL 0.6295 mL 1.2591 mL 3.1477 mL
    30 mM 0.1049 mL 0.5246 mL 1.0492 mL 2.6231 mL
    40 mM 0.0787 mL 0.3935 mL 0.7869 mL 1.9673 mL
    50 mM 0.0630 mL 0.3148 mL 0.6295 mL 1.5739 mL
    60 mM 0.0525 mL 0.2623 mL 0.5246 mL 1.3116 mL
    80 mM 0.0393 mL 0.1967 mL 0.3935 mL 0.9837 mL
    100 mM 0.0315 mL 0.1574 mL 0.3148 mL 0.7869 mL
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    Zinc Pyrithione Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Zinc Pyrithione13463-41-7Proton PumpFungalEnvironmental PollutantsBacterialCuproptosisEnvironmental ContaminantsInhibitorinhibitorinhibit

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