2. Induced Disease Models Products Immunology/Inflammation
  3. Immunology and Inflammatory Disease Models Toll-like Receptor (TLR)
  4. Peritonitis Models
  5. Zymosan A

Zymosan A  (Synonyms: Zymosan A from Saccharomyces cerevisiae)

Cat. No.: HY-W250113 Assay: 82.2%
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Zymosan A (Zymosan A from Saccharomyces cerevisiae) is a TLR2 agonist, that targeting TLRs can prevent and suppress IR-induced intestinal injury. Zymosan A exhibits a significant radioprotective effect, and protects IR-induced intestinal injury in mice. Zymosan A promotes the regeneration of intestinal stem cells (ISCs), after IR injury.

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Zymosan A

Zymosan A Estructura química

No. CAS : 58856-93-2

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Revisión del cliente

Based on 2 publication(s) in Google Scholar

Other Forms of Zymosan A:

Zymosan A Related Antibodies

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Ver todos los productos específicos de isoformas Toll-like Receptor (TLR):

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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Descripciòn

Zymosan A (Zymosan A from Saccharomyces cerevisiae) is a TLR2 agonist, that targeting TLRs can prevent and suppress IR-induced intestinal injury. Zymosan A exhibits a significant radioprotective effect, and protects IR-induced intestinal injury in mice. Zymosan A promotes the regeneration of intestinal stem cells (ISCs), after IR injury[1].

In Vivo

Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Zymosan A (25.0 mg/kg; IP at 12 and 2 h before IR) mitigates IR-induced intestinal injury in mice[1]. Zymosan A can be used in animal modeling to create peritonitis models.

Induction of peritonitis[2]
Background
Zymosan A can mediate the release of pro-inflammatory cytokines including IL-1β, TNF-α, and HMGB1, inducing an inflammatory response leading to peritonitis.
Specific Modeling Methods
Mice: C57BL/6 • male • 3-7 months old
Administration: 100 or 500 mg/kg • i.p.
Note
(1) ChAT-eGFP mice were randomly divided into two groups, and baseline rectal temperature and electrocardiogram (ECG) were measured in each group before injection.
(2) Preparation of Zymosan A Suspension: Weigh Zymosan A and sterilise for 30 minutes with UV light, add sterile filtered saline and vortex thoroughly, store at room temperature overnight and vortex again before use to ensure thorough mixing.
(3) Rectal temperature and ECG were recorded hourly 4 and 24 hours after Zymosan A injection, respectively.
Modeling Indicators
Phenotypic observation: Hypothermia; cardiac insufficiency, including increased variability of baseline heart rate (HR), moderate slowing of ventricular conduction, and decreased cardiac contractility; and bacterial translocation into the peritoneal cavity and bloodstream.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20.0 Gy abdominal irradiation (ABI) model in mice[1]
Dosage: 25.0 mg/kg, dissolved in NS
Administration: IP; injection at 12 and 2 h before IR
Result: Significantly reduced the degree of bleeding and edema in the intestinal tissue.
No. CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

[Zymosan A]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 1.94 mg/mL (ultrasonic and warming and adjust pH to 4 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  Saline

    Solubility: 2 mg/mL; Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 82.2%

SDS (393 KB)

COA (244 KB)

Instrucciones de manejo (2659 KB)
Referencias
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Zymosan A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zymosan A58856-93-2Zymosan A from Saccharomyces cerevisiaeToll-like Receptor (TLR)biochemical assayreagentInhibitorinhibitorinhibit

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Nombre del producto:
Zymosan A
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HY-W250113
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