α-Angelica lactone

Name: α-Angelica lactone
Brand: MedChemExpress
SKU: HY-N0548
Rating: 5.0 (2 reviews)

製品番号: HY-N0548 純度: 98.31%: Data Sheet SDS COA 取扱説明書
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α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes.

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α-Angelica lactone 構造式

CAS 番号 : 591-12-8

容量	価格（税別）	在庫状況	数量
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 27	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 27	在庫あり	Estimated Time of Arrival: December 31
Liquid
500 mg	$25	在庫あり	Estimated Time of Arrival: December 31
1 g	$35	在庫あり	Estimated Time of Arrival: December 31
5 g		お問い合わせ
10 g		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of α-Angelica lactone:

α-Angelica lactone (Standard) お問い合わせ

顧客検証

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純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

Glutathione-S-thansferase (GST) detoxification enzyme^[1]^[2]
UDP-glucononosyltransferase (UGT) detoxification enzyme^[2]

体外実験

α-Angelica lactone (Compound 2a) (1 mmol) produces γ,γ-disubstituted butenolide in 71% yield with 94% ee under the optimal reaction conditions^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

α-Angelica lactone (0.5%, incorporate in diet, daily) significantly increases the GST activity in oesophagus and stomach by 155% and 230% of Wistar rats, respectively^[1].
α-Angelica lactone (0.5% w/w, incorporate in diet, daily) enhances the 4-NP UGT enzyme activity in small intestine, latge intestine, and liver of male Wistar rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (190-210 g)^[1]
Dosage:	0.5%
Administration:	Incorporate in diet, daily for 2 weeks
Result:	Highly induced the oesophageal GST-α levels by 570%. Increased GST-μ levels in ellagic acid-treated rats. Induced pronounced changes in GST-π levels in the stomach by 1120%.

分子量

98.10

分子式

C₅H₆O₂

CAS 番号

591-12-8

Appearance

Liquid (Density: 1.092 g/cm³)

Color

Colorless to light yellow

SMILES

O=C1OC(C)=CC1

Structure Classification

Others

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (1019.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	10.1937 mL	50.9684 mL	101.9368 mL
5 mM	2.0387 mL	10.1937 mL	20.3874 mL
10 mM	1.0194 mL	5.0968 mL	10.1937 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (25.48 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (25.48 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (25.48 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 98.31%

Select Batch:

データシート (278 KB) SDS (394 KB)

COA (249 KB) HNMR (233 KB) GC (218 KB)

取扱説明書 (2659 KB)

参考文献

[1]. W A Nijhoff, et al. Quantification of Induction of Rat Oesophageal, Gastric and Pancreatic Glutathione and Glutathione S-transferases by Dietary Anticarcinogens. Carcinogenesis. 1994 Sep;15(9):1769-72. [Content Brief]

[2]. E M J van der Logt, et al. Induction of Rat Hepatic and Intestinal UDP-glucuronosyltransferases by Naturally Occurring Dietary Anticarcinogens. Carcinogenesis. 2003 Oct;24(10):1651-6. [Content Brief]

[3]. Lin Zhou, et al. Catalytic Asymmetric Vinylogous Mannich-type (AVM) Reaction of Nonactivated α-Angelica Lactone. Org Lett. 2011 Jun 17;13(12):3056-9. [Content Brief]

[4]. Jessica A Griswold, et al. Diastereoselective Organocatalytic Addition of α-Angelica Lactone to β-Halo-α-ketoesters. J Org Chem. 2017 Feb 17;82(4):2276-2280. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	10.1937 mL	50.9684 mL	101.9368 mL	254.8420 mL
	5 mM	2.0387 mL	10.1937 mL	20.3874 mL	50.9684 mL
	10 mM	1.0194 mL	5.0968 mL	10.1937 mL	25.4842 mL
	15 mM	0.6796 mL	3.3979 mL	6.7958 mL	16.9895 mL
	20 mM	0.5097 mL	2.5484 mL	5.0968 mL	12.7421 mL
	25 mM	0.4077 mL	2.0387 mL	4.0775 mL	10.1937 mL
	30 mM	0.3398 mL	1.6989 mL	3.3979 mL	8.4947 mL
	40 mM	0.2548 mL	1.2742 mL	2.5484 mL	6.3711 mL
	50 mM	0.2039 mL	1.0194 mL	2.0387 mL	5.0968 mL
	60 mM	0.1699 mL	0.8495 mL	1.6989 mL	4.2474 mL
	80 mM	0.1274 mL	0.6371 mL	1.2742 mL	3.1855 mL
	100 mM	0.1019 mL	0.5097 mL	1.0194 mL	2.5484 mL