591-12-8
Chemical Structure
α-Angelica lactone
- CAS No.: 591-12-8
- Formula:C5H6O2
- Molecular Weight:98.10
IUPAC Name: 5-methylfuran-2(3H)-one
InChIKey: QOTQFLOTGBBMEX-UHFFFAOYSA-N
SMILES: O=C1OC(C)=CC1
Biological Activity: α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
α-Angelica lactone | 98.24% | α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
α-Angelica lactone (Standard) | ≥98% | α-Angelica lactone (Standard) is the analytical standard of α-Angelica lactone. This product is intended for research and analytical applications. α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.72
HY-79369Succinic anhydride -
Similarity Score 0.72
HY-79369S1Succinic anhydride-13C2 -
Similarity Score 0.70
HY-N6610Protoanemonin -
Similarity Score 0.67
HY-107931Propiolactone -
Similarity Score 0.65
HY-W0447625,6-Dihydro-2H-pyran-2-one -
Similarity Score 0.65
HY-W012997Tetrahydro-2H-pyran-2-one -
Similarity Score 0.65
HY-129434Nepetalactone -
Similarity Score 0.65
HY-129434A4aα,7α,7aα-Nepetalactone -
Similarity Score 0.64
HY-W015891ε-Caprolactone -
Explore the MedChemAI to find more analogs
References
- [1]. W A Nijhoff, et al. Quantification of Induction of Rat Oesophageal, Gastric and Pancreatic Glutathione and Glutathione S-transferases by Dietary Anticarcinogens. Carcinogenesis. 1994 Sep;15(9):1769-72. [Content Brief]
- [2]. E M J van der Logt, et al. Induction of Rat Hepatic and Intestinal UDP-glucuronosyltransferases by Naturally Occurring Dietary Anticarcinogens. Carcinogenesis. 2003 Oct;24(10):1651-6. [Content Brief]
- [3]. Lin Zhou, et al. Catalytic Asymmetric Vinylogous Mannich-type (AVM) Reaction of Nonactivated α-Angelica Lactone. Org Lett. 2011 Jun 17;13(12):3056-9. [Content Brief]
- [4]. Jessica A Griswold, et al. Diastereoselective Organocatalytic Addition of α-Angelica Lactone to β-Halo-α-ketoesters. J Org Chem. 2017 Feb 17;82(4):2276-2280. [Content Brief]
